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    SIMPLIFIED PERITONEAL EQUILIBRATION TEST FOR PERITONEAL DIALYSIS
    11.
    发明申请
    SIMPLIFIED PERITONEAL EQUILIBRATION TEST FOR PERITONEAL DIALYSIS 有权
    简单的PERITONEAL EQUILIBRATION测试用于腹膜透析

    公开(公告)号：US20110010101A1

    公开(公告)日：2011-01-13

    申请号：US12498847

    申请日：2009-07-07

    Applicant: Ying-Cheng Lo ,  Alp Akonur ,  Sarah Stobo Prichard

    Inventor： Ying-Cheng Lo ,  Alp Akonur ,  Sarah Stobo Prichard

    IPC: G06F19/00

    CPC classification number: A61M1/28 ,  A61M1/1619

    Abstract: A simplified peritoneal equilibration test (S-PET) is disclosed. Instead of a lengthy peritoneal equilibration test (PET), the simplified procedure requires no blood sample and may use data from as few as two or three samples to classify a peritoneal membrane of a user. Typically, a peritoneal membrane or peritoneum of a dialysis patient, or other person, is classed as a high transport membrane, high-average transport membrane, a low-average transport membrane or a low transporter membrane. The S-PET may be performed at home by a user without the need to submit a blood sample. Kits for analyzing the samples may be furnished for home use. The kits may use disposable strips, microfluidic analyzers or chemical reagents, or may alternatively include reusable analysis equipment, such as optical or conductivity analysis equipment.

    Abstract translation: 公开了一种简化的腹膜平衡试验（S-PET）。 代替长时间的腹膜平衡试验（PET），简化的程序不需要血液样品，并且可以使用少至两个或三个样品的数据来分类用户的腹膜。 通常，透析患者或其他人的腹膜或腹膜被分类为高运输膜，高平均运输膜，低平均运输膜或低转运膜。 S-PET可以由用户在家进行，而不需要提交血样。 用于分析样品的试剂盒可供家庭使用。 试剂盒可以使用一次性条，微流控分析仪或化学试剂，或者可以替代地包括可重复使用的分析设备，例如光学或电导率分析设备。

    SIMULATION OF PATIENT DRAIN PHASE IN PERITONEAL DIALYSIS
    12.
    发明申请
    SIMULATION OF PATIENT DRAIN PHASE IN PERITONEAL DIALYSIS 有权
    腹膜透析患者浸液相的模拟

    公开(公告)号：US20100217180A1

    公开(公告)日：2010-08-26

    申请号：US12389886

    申请日：2009-02-20

    Applicant: Alp Akonur ,  Ying-Cheng Lo

    Inventor： Alp Akonur ,  Ying-Cheng Lo

    IPC: A61M1/28 ,  G06F17/10 ,  G06G7/57 ,  G06G7/60

    CPC classification number: G16H50/50 ,  A61M1/28 ,  A61M1/282

    Abstract: A method of modeling a patient's peritoneal dialysis drain phase includes (i) modeling a first segment of a drain phase curve as having a constant flowrate; (ii) modeling a second segment of a drain phase curve as having a decaying exponential flowrate; and (iii) incorporating a switching component into the first and second components so that (a) at a first time the first segment is active and while the second segment is inactive and (b) at a second time the first segment is inactive and while the second segment is active.

    Abstract translation: 建模患者腹膜透析排泄阶段的方法包括（i）将排水相曲线的第一段建模为具有恒定的流速; （ii）将排水相曲线的第二段建模为具有衰减指数流速; 以及（iii）将切换组件并入到所述第一和第二组件中，使得（a）在第一时间第一段处于活动状态，而第二段处于非活动状态，并且（b）在第二时间段，第一段无效，而 第二段是活跃的。

    OPTIMIZING THERAPY OUTCOMES FOR PERITONEAL DIALYSIS
    13.
    发明申请
    OPTIMIZING THERAPY OUTCOMES FOR PERITONEAL DIALYSIS 有权
    优化治疗结果进行透析

    公开(公告)号：US20090275881A1

    公开(公告)日：2009-11-05

    申请号：US12431458

    申请日：2009-04-28

    Applicant: Ying-Cheng Lo ,  Alp Akonur ,  Isaac Martis

    Inventor： Ying-Cheng Lo ,  Alp Akonur ,  Isaac Martis

    IPC: A61M1/28 ,  A61B5/00 ,  A61B5/107 ,  G06F17/10 ,  G06F17/30

    CPC classification number: G06F19/3481 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M2205/3569 ,  A61M2205/52 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/6072 ,  G06F19/00

    Abstract: Peritoneal dialysis therapy outcomes have been calculated for a variety of dwell times of peritoneal dialysis fluids in the peritoneal cavities of dialysis patients using kinetic modeling. The length of dwell time should not be the same for every patient, but should vary according to the patient condition and needs. Some patients have a potential for expressing greater ultrafiltrate into the dialysis fluid, and these patients can benefit from a longer dwell time, whereas other patients with less potential will not benefit from a longer dwell time. An optimal or peak time is observed for each peritoneal dialysis therapy outcome, such as ultrafiltrate volume rate, urea clearance (Kt/V), and creatinine clearance, while minimizing hydrocarbon absorption. These values and input parameters can be used to tailor the peritoneal dialysis dwell time for each patient, estimating the peak dwell time that will yield the best therapy outcome for each patient.

    Abstract translation: 已经使用动力学模型计算了透析患者腹膜腔腹膜透析液的各种停留时间的腹膜透析治疗结果。 每个患者的停留时间长度不应相同，但应根据患者情况和需要而变化。 一些患者有可能在透析液中表达更多的超滤液，这些患者可以从更长的停留时间中受益，而潜在的潜力较小的患者不会受益于更长的停留时间。 对于每个腹膜透析治疗结果观察到最佳或高峰时间，例如超滤液体积率，尿素清除率（Kt / V）和肌酐清除率，同时使烃吸收最小化。 这些值和输入参数可用于定制每个患者的腹膜透析停留时间，估计将为每位患者产生最佳治疗结果的峰值停留时间。

    Drain and fill logic for automated peritoneal dialysis
    15.
    发明授权
    Drain and fill logic for automated peritoneal dialysis 有权
    自动腹膜透析的排水和填充逻辑

    公开(公告)号：US08936720B2

    公开(公告)日：2015-01-20

    申请号：US13195376

    申请日：2011-08-01

    Applicant: Robert W. Childers ,  Ying-Cheng Lo ,  Peter Hopping

    Inventor： Robert W. Childers ,  Ying-Cheng Lo ,  Peter Hopping

    IPC: A61M1/28 ,  B01D61/32

    CPC classification number: A61M1/28 ,  A61M1/282

    Abstract: The present system and method in one embodiment limit a maximum instantaneous peritoneal volume to a comfortable level, while allowing the dialysis machine to advance to fill a prescribed volume whenever the drain ends after a minimum drain percentage has been attained. If a low drain condition occurs, the nominal fill volume is lowered and a therapy cycle is added, so that a prescribed total amount of fresh therapy fluid is used during therapy, maximizing therapeutic benefit. An allowable residual volume at the end of an incomplete drain is increased, thereby lowering the probability of a subsequent low drain condition.

    Abstract translation: 在一个实施例中，本系统和方法将最大瞬时腹膜容积限制到舒适水平，同时每当排水终点达到最小排水百分比后，允许透析机前进以填充规定的体积。 如果发生低排泄状况，则标称填充体积降低并加入治疗周期，使得在治疗期间使用规定的总量的新鲜治疗液，使治疗效果最大化。 在不完全排水结束时允许的剩余体积增加，从而降低随后的低排放条件的可能性。

    Hemodialysis system with separate dialysate cassette
    16.
    发明授权
    Hemodialysis system with separate dialysate cassette 有权
    血液透析系统与单独的透析胶带

    公开(公告)号：US08926540B2

    公开(公告)日：2015-01-06

    申请号：US13213812

    申请日：2011-08-19

    Applicant: Ying-Cheng Lo ,  Robert W. Childers ,  Thomas D. Kelly ,  Justin Rohde

    Inventor： Ying-Cheng Lo ,  Robert W. Childers ,  Thomas D. Kelly ,  Justin Rohde

    IPC: A61M1/38 ,  A61M1/14 ,  A61M1/16 ,  A61M1/28 ,  A61M1/34

    CPC classification number: A61M1/1639 ,  A61M1/16 ,  A61M1/1603 ,  A61M1/1605 ,  A61M1/1635 ,  A61M1/166 ,  A61M1/28 ,  A61M1/284 ,  A61M1/34 ,  A61M1/3627 ,  A61M2205/127 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/502 ,  Y10T29/49826

    Abstract: A hemodialysis system includes (i) a dialyzer; (ii) a blood pump; (iii) a blood cassette operatively connected to the dialyzer and the blood pump; (iv) a dialysate heater; (v) first and second peristaltic dialysate pumps; and (vi) a dialysate cassette separate from the blood cassette, the dialysate cassette including an organizer configured to support a drain tube, a to-dialyzer tube and a from-dialyzer tube, the cassette further including a first pumping tube, a second pumping tube and an inline fluid heating pathway, the cassette when mounted for operation orienting (a) the first pumping tube for operation with the first peristaltic dialysate pump, (b) the second pumping tube for operation with the second peristaltic dialysate pump and (c) the fluid heating pathway for operation with the dialysate heater.

    Abstract translation: 血液透析系统包括（i）透析器; （ii）血液泵; （iii）可操作地连接到透析器和血液泵的血盒; （iv）透析液加热器; （v）第一和第二蠕动透析液泵; 和（vi）与血液盒分离的透析盒，所述透析液盒包括构造成支撑排液管，透析器管和透析器管的组织器，所述盒还包括第一泵管，第二抽吸 管和管线流体加热通道，当安装用于操作时的盒子定向（a）用于与第一蠕动透析泵一起操作的第一泵管，（b）用于与第二蠕动透析泵一起操作的第二泵管，以及（c） 用于与透析液加热器一起操作的流体加热路径。

    DRAIN AND FILL LOGIC FOR AUTOMATED PERITONEAL DIALYSIS
    18.
    发明申请
    DRAIN AND FILL LOGIC FOR AUTOMATED PERITONEAL DIALYSIS 有权
    用于自动化透析的排水和填充逻辑

    公开(公告)号：US20120215159A1

    公开(公告)日：2012-08-23

    申请号：US13458625

    申请日：2012-04-27

    Applicant: Robert W. Childers ,  Ying-Cheng Lo ,  Peter A. Hoping

    Inventor： Robert W. Childers ,  Ying-Cheng Lo ,  Peter A. Hoping

    IPC: A61M1/28

    CPC classification number: A61M1/284 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M2205/3379 ,  B01D61/30 ,  B01D61/32

    Abstract: A system and method for automatically adjusting a Continuous Cycling Peritoneal Dialysis (“CCPD”) therapy to minimize the potential for excess intra-peritoneal volume. The adjustments are made at the end of the drain, just prior to the next fill. The adjustments short the next fill, if necessary, to limit the intra-peritoneal volume, add a cycle, if necessary, to use all of the available dialysis solution and will average the remaining dwell time to maximize the therapeutic benefit of the therapy in the allotted time. In another embodiment, a tidal therapy using trended patient UF data is provided.

    Abstract translation: 一种用于自动调节连续循环腹膜透析（“CCPD”）治疗的系统和方法，以最大限度地减少腹膜内多余的体积。 调整是在排水结束时进行的，就在下一次填充之前。 如果需要，调整缩短下一次填充，以限制腹膜内体积，如果需要，添加一个循环，以使用所有可用的透析溶液，并将平均剩余停留时间，以最大化治疗的治疗效果 分配时间 在另一个实施例中，提供使用趋势化患者UF数据的潮汐治疗。

    Drain and fill logic for automated peritoneal dialysis
    19.
    发明授权
    Drain and fill logic for automated peritoneal dialysis 有权
    自动腹膜透析的排水和填充逻辑

    公开(公告)号：US08182673B2

    公开(公告)日：2012-05-22

    申请号：US12362259

    申请日：2009-01-29

    Applicant: Robert W. Childers ,  Ying-Cheng Lo ,  Peter A. Hopping

    Inventor： Robert W. Childers ,  Ying-Cheng Lo ,  Peter A. Hopping

    IPC: B01D61/32

    CPC classification number: A61M1/284 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M2205/3379 ,  B01D61/30 ,  B01D61/32

    Abstract: A system and method for automatically adjusting a Continuous Cycling Peritoneal Dialysis (“CCPD”) therapy to minimize the potential for excess intra-peritoneal volume. The adjustments are made at the end of the drain, just prior to the next fill. The adjustments short the next fill, if necessary, to limit the intra-peritoneal volume, add a cycle, if necessary, to use all of the available dialysis solution and will average the remaining dwell time to maximize the therapeutic benefit of the therapy in the allotted time. In another embodiment, a tidal therapy using trended patient UF data is provided.

    Abstract translation: 一种用于自动调节连续循环腹膜透析（“CCPD”）治疗的系统和方法，以最大限度地减少腹膜内多余的体积。 调整是在排水结束时进行的，就在下一次填充之前。 如果需要，调整缩短下一次填充，以限制腹膜内体积，如果需要，添加一个循环，以使用所有可用的透析溶液，并将平均剩余停留时间，以最大化治疗的治疗效果 分配时间 在另一个实施例中，提供使用趋势化患者UF数据的潮汐治疗。

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