公开(公告)号：US20240218386A1

公开(公告)日：2024-07-04

申请号：US17781797

申请日：2020-12-02

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan KUDITHIPUDI ,  Chengalrayan KUDITHIPUDI ,  Yanxin SHEN ,  Dongmei XU

IPC: C12N15/82 ,  A24B13/00 ,  A24B15/00

CPC classification number: C12N15/8243 ,  A24B13/00 ,  A24B15/00

Abstract: The present disclosure provides composition and methods for manipulating alkaloid or nicotine levels in tobacco plants. Also provided are the identification and genetic engineering of target genes (e.g., arginine decarboxylase (ADC), aspartate oxidase (AO), or ornithine decarboxylase (ODC)) for producing tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.

公开(公告)号：US20240067979A1

公开(公告)日：2024-02-29

申请号：US18492930

申请日：2023-10-24

Applicant: Altria Client Services LLC

Inventor： Sreepriya PRAMOD ,  Andrew C. ADAMS ,  Marcos Fernando DE GODOY LUSSO ,  Gregory A. DAVIS ,  Jerry W. MORRIS ,  Dongmei XU ,  Jesse FREDERICK

IPC: C12N15/82

CPC classification number: C12N15/8243

Abstract: The present disclosure relates to tobacco plants, tobacco seeds, compositions, and methods related to the identification and introgression of the Pale Yellow locus in tobacco. It also relates to generating novel mutations within the PY locus in tobacco.

公开(公告)号：US20220243215A1

公开(公告)日：2022-08-04

申请号：US17591033

申请日：2022-02-02

Applicant: ALTRIA CLIENT SERVICES LLC ,  UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Chengalrayan KUDITHIPUDI ,  Yanxin SHEN ,  Dongmei XU ,  Michael Paul TIMKO ,  Roel RABARA

IPC: C12N15/82 ,  C07K14/415 ,  C12P5/00

Abstract: Composition and methods for the modification of the secondary metabolic functions of glandular trichomes in plants, such as tobacco or Cannabis, that control the formation of terpenes that impart specific flavor and aroma characteristics to the plant leaves are provided. Enhanced terpene production and composition are achieved through targeted modification in the biochemical synthesis pathways for menthol and cis-abienol. This application provides novel nucleotide sequences encoding the enzymology for production of these terpenes in tobacco and Cannabis application to their use plants.

公开(公告)号：US20220240474A1

公开(公告)日：2022-08-04

申请号：US17704650

申请日：2022-03-25

Applicant: Altria Client Services LLC

Inventor： Andrew C. Adams ,  Marcos F. de GODOY LUSSO ,  Sreepriya PRAMOD ,  Dongmei XU

IPC: A01H6/82 ,  A01H5/12

Abstract: The present application provides tobacco inbred plants dS1746, dS1746MS, dS1564 and dS1564MS. The present application also provides parts of such plants and products made from those parts. The present application also includes progeny of the provided plants including hybrids.

公开(公告)号：US20200029522A1

公开(公告)日：2020-01-30

申请号：US16523326

申请日：2019-07-26

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan KUDITHIPUDI ,  Dong QI ,  Yanxin SHEN ,  Ujwala WAREK ,  James A. STRICKLAND ,  Dongmei XU

IPC: A01H5/12 ,  A01H6/82 ,  C12Q1/6827

Abstract: The present disclosure provides compositions and methods related to tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.

公开(公告)号：US20190216037A1

公开(公告)日：2019-07-18

申请号：US16246308

申请日：2019-01-11

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Sreepriya PRAMOD ,  Marcos Fernando de GODOY LUSSO ,  Jesse FREDERICK ,  Andrew Carl ADAMS ,  Dongmei XU

IPC: A01H6/82 ,  A01H5/12 ,  A01H1/06 ,  A24B3/12 ,  A24B3/08

CPC classification number: A01H6/823 ,  A01H1/06 ,  A01H5/12 ,  A24B3/08 ,  A24B3/12 ,  A24B13/00 ,  A24B15/20 ,  A24B15/243 ,  C12N15/8218

Abstract: The present disclosure provides tobacco Nic1b locus and associated genes (e.g., a group of ERF genes). Also provided are tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants. Further provided are compositions and methods for producing tobacco plants having novel mutations or alleles to reduce nicotine levels. Further provided are sequence polymorphisms and molecular markers for breeding tobacco with reduced nicotine or alkaloids while maintaining tobacco leaf grade and tobacco product quality.

公开(公告)号：US20250098728A1

公开(公告)日：2025-03-27

申请号：US18975272

申请日：2024-12-10

Applicant: Altria Client Services LLC

Inventor： Yahya KARGA ,  James POWELL ,  Dongmei XU ,  James A. STRICKLAND ,  Ujwala WAREK

IPC: A24B15/22 ,  A24B13/00 ,  A24B15/10 ,  A24B15/18 ,  A24B15/28

Abstract: A stabilizing process for tobacco and tobacco products includes sterilizing the tobacco by applying an electron beam treatment to the tobacco. The process may also include treating the tobacco. The treating the tobacco includes pre-conditioning the tobacco, pasteurizing the tobacco, curing the tobacco, fermenting the tobacco, or combinations thereof. The method may also include forming a smokeless tobacco product containing the tobacco.

公开(公告)号：US20250011803A1

公开(公告)日：2025-01-09

申请号：US18896070

申请日：2024-09-25

Applicant: Altria Client Services LLC

Inventor： Chengalrayan KUDITHIPUDI ,  Dongmei XU ,  James Strickland

IPC: C12N15/82 ,  A01H4/00 ,  A24B13/00 ,  A24B15/10 ,  A24B15/24 ,  B01F33/45 ,  B01F33/452 ,  B01F33/501 ,  B01F35/75 ,  B01L3/00 ,  C07K14/415 ,  C12N9/04 ,  G01N1/38 ,  G01N35/00 ,  G01N35/10 ,  H02N11/00

Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

公开(公告)号：US20240150783A1

公开(公告)日：2024-05-09

申请号：US18505449

申请日：2023-11-09

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Yanxin SHEN ,  Dongmei XU

IPC: C12N15/82 ,  A01H1/06 ,  A01H5/12 ,  A24B13/00 ,  C07K14/415 ,  C12N9/02

CPC classification number: C12N15/8261 ,  A01H1/06 ,  A01H5/12 ,  A24B13/00 ,  C07K14/415 ,  C12N9/0073 ,  C12N15/8218 ,  C12N15/825 ,  C12N15/8251 ,  C12N15/8269 ,  C12Y114/13122 ,  Y02A40/146

Abstract: This disclosure provides tobacco plants that exhibit altered photosynthesis as well as methods of making and using such plants.

公开(公告)号：US20240067977A1

公开(公告)日：2024-02-29

申请号：US17766786

申请日：2020-10-09

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan KUDITHIPUDI ,  Rajanikanth GOVINDARAJULU ,  Nazmul BHUIYAN ,  Raija PAYYAVULA ,  Yanxin SHEN ,  Dongmei XU

IPC: C12N15/82 ,  C07K14/415 ,  C12N15/113

CPC classification number: C12N15/8243 ,  C07K14/415 ,  C12N15/1137

Abstract: The present disclosure provides composition and methods for improving leaf quality of low-alkaloid tobacco plants. Also provided are the identification and genetic engineering of target genes (Leaf Quality Genes) for producing tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.