公开(公告)号：US10647989B2

公开(公告)日：2020-05-12

申请号：US15727523

申请日：2017-10-06

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Dongmei Xu ,  James Strickland

IPC: C12N15/82 ,  A24B15/24 ,  A24B15/10 ,  C12N9/04 ,  A01H4/00 ,  A24B13/00 ,  C07K14/415

Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radical absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

公开(公告)号：US11879130B2

公开(公告)日：2024-01-23

申请号：US17406829

申请日：2021-08-19

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Dongmei Xu ,  Jesse Frederick ,  Chengalrayan Kudithipudi ,  Yanxin Shen ,  James Strickland ,  Jaemo Yang

IPC: C12N15/82 ,  C07K14/415

CPC classification number: C12N15/8265 ,  C07K14/415 ,  C12N15/8213 ,  C12N15/8218 ,  C12N15/8225 ,  C12N15/8229 ,  C12N15/8261 ,  C12N15/8262 ,  C12N15/8294 ,  C12N2310/20

Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US20230348925A1

公开(公告)日：2023-11-02

申请号：US18182701

申请日：2023-03-13

Applicant: Altria Client Services LLC

Inventor： Chengalrayan KUDITHIPUDI ,  Dongmei XU ,  James Strickland

IPC: C12N15/82 ,  C12N9/04 ,  A24B15/24 ,  B01L3/00 ,  G01N1/38 ,  H02N11/00 ,  B01F33/45 ,  B01F33/452 ,  B01F33/501 ,  B01F35/75 ,  A01H4/00 ,  A24B13/00 ,  A24B15/10 ,  C07K14/415

CPC classification number: C12N15/8243 ,  C12N9/0006 ,  A24B15/245 ,  C12N15/825 ,  B01L3/502 ,  B01L3/50825 ,  G01N1/38 ,  H02N11/006 ,  B01F33/45 ,  B01F33/452 ,  B01F33/50112 ,  B01F35/754251 ,  A01H4/005 ,  A01H4/008 ,  A24B13/00 ,  A24B15/10 ,  C07K14/415 ,  C12N15/8205 ,  C12N15/8225 ,  B01L2200/0684 ,  B01L2300/043 ,  B01L2300/0672 ,  B01L2300/0867 ,  B01L2400/0403 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0683 ,  G01N35/1079

Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

公开(公告)号：US20210275980A1

公开(公告)日：2021-09-09

申请号：US16838762

申请日：2020-04-02

Applicant: Altria Client Services LLC

Inventor： Chengalrayan KUDITHIPUDI ,  Dongmei XU ,  James Strickland

IPC: B01F13/08 ,  G01N1/38 ,  B01F15/02 ,  B01L3/00 ,  B01F13/00 ,  H02N11/00

Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

公开(公告)号：US11104912B2

公开(公告)日：2021-08-31

申请号：US16124941

申请日：2018-09-07

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Dongmei Xu ,  Jesse Frederick ,  Chengalrayan Kudithipudi ,  Yanxin Shen ,  James Strickland ,  Jaemo Yang

IPC: C12N15/82 ,  C07K14/415

Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US20180119163A1

公开(公告)日：2018-05-03

申请号：US15727523

申请日：2017-10-06

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Dongmei Xu ,  James Strickland

IPC: C12N15/82 ,  A01H4/00 ,  C07K14/415 ,  A24B15/10 ,  A24B13/00

CPC classification number: C12N15/8243 ,  A01H4/005 ,  A01H4/008 ,  A24B13/00 ,  A24B15/10 ,  A24B15/245 ,  C07K14/415 ,  C12N9/0006 ,  C12N15/8205 ,  C12N15/8225 ,  C12N15/825

Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

公开(公告)号：US12286637B2

公开(公告)日：2025-04-29

申请号：US18537046

申请日：2023-12-12

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Dongmei Xu ,  Jesse Frederick ,  Chengalrayan Kudithipudi ,  Yanxin Shen ,  James Strickland ,  Jaemo Yang

IPC: C12N15/82 ,  C07K14/415

Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US20250129379A1

公开(公告)日：2025-04-24

申请号：US18985344

申请日：2024-12-18

Applicant: Altria Client Services LLC

Inventor： Dongmei Xu ,  Chengalrayan Kudithipudi ,  Yanxin Shen ,  Jaemo Yang ,  Jesse Frederick ,  James Strickland

IPC: C12N15/82 ,  A24B13/00 ,  A24B15/10 ,  C07K14/415

Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US12209249B2

公开(公告)日：2025-01-28

申请号：US18476495

申请日：2023-09-28

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Dongmei Xu ,  Chengalrayan Kudithipudi ,  Yanxin Shen ,  Jaemo Yang ,  Jesse Frederick ,  James Strickland

IPC: C12N15/82 ,  A24B13/00 ,  A24B15/10 ,  C07K14/415

Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US20250011803A1

公开(公告)日：2025-01-09

申请号：US18896070

申请日：2024-09-25

Applicant: Altria Client Services LLC

Inventor： Chengalrayan KUDITHIPUDI ,  Dongmei XU ,  James Strickland

IPC: C12N15/82 ,  A01H4/00 ,  A24B13/00 ,  A24B15/10 ,  A24B15/24 ,  B01F33/45 ,  B01F33/452 ,  B01F33/501 ,  B01F35/75 ,  B01L3/00 ,  C07K14/415 ,  C12N9/04 ,  G01N1/38 ,  G01N35/00 ,  G01N35/10 ,  H02N11/00

Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.