公开(公告)号：US20110301332A1

公开(公告)日：2011-12-08

申请号：US13001744

申请日：2009-07-01

申请人： David Wilson ,  Tetsuya Taura

发明人： David Wilson ,  Tetsuya Taura

IPC分类号： C07K16/18 ,  C12N5/18

CPC分类号： C07K16/26 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

摘要： The invention relates to antibodies and antigen-binding fragments thereof which bind to proadrenomedullin N-terminal peptide (“PAMP”). Furthermore, the invention comprises monoclonal antibody EGX-P-E9 as well as engineered variants thereof, including chimeric, humanized or de-immunized versions thereof. The antibodies of the invention are useful for inhibiting the physiological activities of PAMP as well as in diagnosis of PAMP-responsive conditions.

摘要翻译： 本发明涉及与前肾上腺髓质素N-末端肽（“PAMP”）结合的抗体及其抗原结合片段。 此外，本发明包括单克隆抗体EGX-P-E9及其工程变体，包括其嵌合，人源化或去免疫的形式。 本发明的抗体可用于抑制PAMP的生理活性以及PAMP反应性病症的诊断。

公开(公告)号：US20110263533A1

公开(公告)日：2011-10-27

申请号：US13124898

申请日：2009-10-12

申请人： Qun Dang ,  Tony S. Gibson ,  Hongjian Jiang ,  De Michael Chung ,  Jianming Bao ,  Jinlong Jiang ,  Andy Kassick ,  Ahmet Kekec ,  Ping Lan ,  Huagang Lu ,  Gergely M. Makara ,  F. Anthony Romero ,  Iyassu Sebhat ,  David Wilson ,  Dariusz Wodka ,  Brett C. Bookser

发明人： Qun Dang ,  Tony S. Gibson ,  Hongjian Jiang ,  De Michael Chung ,  Jianming Bao ,  Jinlong Jiang ,  Andy Kassick ,  Ahmet Kekec ,  Ping Lan ,  Huagang Lu ,  Gergely M. Makara ,  F. Anthony Romero ,  Iyassu Sebhat ,  David Wilson ,  Dariusz Wodka ,  Brett C. Bookser

IPC分类号： A61K31/675 ,  C07F9/40 ,  C07F9/6574 ,  A61P35/00 ,  A61P3/04 ,  A61P3/06 ,  A61P9/12 ,  C07F9/6506 ,  A61P3/10

CPC分类号： C07F9/65068 ,  C07F9/65583 ,  C07F9/657181

摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.

摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖，高胆固醇血症和高血压。

公开(公告)号：US07992319B2

公开(公告)日：2011-08-09

申请号：US10573057

申请日：2004-09-24

申请人： David Wilson

发明人： David Wilson

IPC分类号： F26B17/12

CPC分类号： F26B25/12 ,  C10F5/00 ,  F23K1/04 ,  F23K2201/20 ,  F26B17/122 ,  F26B17/126 ,  F26B21/08

摘要： The invention provides a dryer for drying particulate material, comprising at least one substantially vertical elongate container having: an upper inlet for receiving a charge of moisture containing particulate material; a lower outlet for discharging dried particulate material, whereby the particulate material travels under the influence of gravity from the inlet to the outlet; at least one substantially vertical gas permeable wall through which a drying gas can pass to contact the particulate material; the dryer also comprising at least one plenum on an exterior surface of the at least one gas permeable wall, covering ingress and egress openings within the at least one gas permeable wall.

摘要翻译： 本发明提供了一种用于干燥颗粒材料的干燥器，包括至少一个基本垂直的细长容器，其具有：用于接收含有颗粒材料的水分的上部入口; 用于排出干燥的颗粒材料的下部出口，由此颗粒材料在重力作用下从入口到出口的行进; 至少一个基本上垂直的透气壁，干燥气体可以穿过该壁与颗粒材料接触; 所述干燥器还包括在所述至少一个气体可渗透壁的外表面上的至少一个增压室，其覆盖所述至少一个气体可渗透壁内的入口和出口。

公开(公告)号：US20110105067A1

公开(公告)日：2011-05-05

申请号：US12937573

申请日：2009-03-25

申请人： David Wilson

发明人： David Wilson

IPC分类号： H03G3/00 ,  H04B1/18

CPC分类号： H03G1/0029 ,  H03G1/0017 ,  H03G1/0088

摘要： A wideband tuneable low noise amplifier that is capable of receiving signals over a wide range of frequencies, providing tuneable filtering to remove out of band interferer signals, and providing variable gain for a wide range of frequencies. To accommodate variable gain, the low noise amplifier has an amplifier stage comprising two gain stages, and the relationship between the gain stages is controlled responsive to changes in the voltage gain of an input stage. Linearity monitoring combined with Q-enhance may be employed to increase performance at low signal levels.

摘要翻译： 宽带可调低噪声放大器，能够在宽范围的频率范围内接收信号，提供可调滤波以去除带外干扰信号，并为广泛的频率提供可变增益。 为了适应可变增益，低噪声放大器具有包括两个增益级的放大器级，响应于输入级的电压增益的变化来控制增益级之间的关系。 可以采用与Q增强相结合的线性监测来提高低信号电平下的性能。

公开(公告)号：US20100245198A1

公开(公告)日：2010-09-30

申请号：US12748804

申请日：2010-03-29

申请人： David Wilson

发明人： David Wilson

IPC分类号： H01Q1/38 ,  H01Q1/48 ,  H01Q13/10 ,  H01Q9/06

CPC分类号： H01Q9/0442 ,  H01Q1/243 ,  H01Q1/38 ,  H01Q5/20 ,  H01Q5/357 ,  H01Q9/42 ,  H01Q13/10

摘要： A surface mount antenna includes a ground plane, a feed line, and a radiating element. The ground plane extends in a first direction on a first side of a substrate. The feed line extends in a second direction on a second side of the substrate. The radiating element includes a plurality of segments disposed on the first side of the substrate and is configured to resonate in a plurality of frequency modes.

摘要翻译： 表面安装天线包括接地平面，馈线和辐射元件。 接地平面在基板的第一面上沿第一方向延伸。 馈送线在衬底的第二侧沿第二方向延伸。 辐射元件包括设置在衬底的第一侧上并被配置为以多个频率模式谐振的多个段。

公开(公告)号：US20080148351A1

公开(公告)日：2008-06-19

申请号：US11641297

申请日：2006-12-18

申请人： Gaurav Bhatia ,  Kamalendu Biswas ,  David Wilson

发明人： Gaurav Bhatia ,  Kamalendu Biswas ,  David Wilson

IPC分类号： G06F7/04

CPC分类号： G06F21/6218 ,  G06F2221/2113 ,  G06F2221/2137

摘要： One embodiment of the present invention provides a system that provides access to an application-resource. During operation, the system receives a request to access an application-resource associated with an application, wherein the request is received at an application-server that hosts the application. The system then determines an authentication-level required to access the application-resource. Next, the system sends the required authentication-level to an authentication-server. In response, the system receives an authentication-response from the authentication-server. Next, the system determines if the authentication-response specifies that the user is authenticated to access the application-resource. If so, the system grants the user access to the application-resource.One embodiment of the present invention provides a system that provides an authentication-token associated with a lower authentication-level in response to an authentication-token associated with a higher authentication-level expiring. Note that the lower authentication-level meets or exceeds a required authentication-level and does not require a user to re-authenticate.

摘要翻译： 本发明的一个实施例提供一种提供对应用资源的访问的系统。 在操作期间，系统接收访问与应用相关联的应用资源的请求，其中在承载应用的应用服务器处接收该请求。 然后，系统确定访问应用程序资源所需的认证级别。 接下来，系统向认证服务器发送所需的认证级别。 作为响应，系统从认证服务器接收认证响应。 接下来，系统确定认证响应是否指定用户被认证以访问应用资源。 如果是这样，系统授予用户对应用程序资源的访问权限。 本发明的一个实施例提供了一种系统，其响应于与较高认证级别到期关联的认证令牌来提供与较低认证级别相关联的认证令牌。 请注意，较低的认证级别满足或超过所需的认证级别，并且不要求用户重新认证。

公开(公告)号：US20080134841A1

公开(公告)日：2008-06-12

申请号：US12004757

申请日：2007-12-21

申请人： David Wilson

发明人： David Wilson

IPC分类号： B25B13/50 ,  H02H7/00 ,  G08B21/00

CPC分类号： B25B13/481 ,  B25B21/00 ,  B25B21/002 ,  B25B23/145 ,  B25B23/147

摘要： A powered driver and methods are disclosed, the driver including a head having a gapped jaw and housing a motor driven drive transfer assembly for operating a rotatable split socket engageable at a threaded connector. A reaction unit having a biased fitting engagement attached to rail guides is movably maintained through the head, and a probe and switch are associated with different ones of the reaction unit and the head. A safety assembly includes a biased gate switch engageable with a signal switch and is located at the head for sending run status electrical signals to the driver dependent on position of the gate switch. Indicator and control arrays are provided for user interface and driver status monitoring.

摘要翻译： 公开了一种动力驱动器和方法，所述驱动器包括具有有间隙的钳口的头部，并且容纳用于操作可接合在螺纹连接器处的可旋转分裂插座的马达驱动驱动传递组件。 具有附接到轨道导轨的偏置配合接合件的反作用单元通过头部被可移动地保持，并且探针和开关与反应单元和头部中的不同部件相关联。 安全组件包括可与信号开关接合的偏置门开关，并且位于头部，用于根据门开关的位置向驾驶员发送运行状态电信号。 提供指示器和控制阵列用于用户界面和驱动程序状态监视。

公开(公告)号：US20080099190A1

公开(公告)日：2008-05-01

申请号：US11850028

申请日：2007-09-04

申请人： Rajiv Singh ,  Hang Pham ,  David Wilson ,  Raymond Thomas ,  Mark Spatz ,  David Metcalf

发明人： Rajiv Singh ,  Hang Pham ,  David Wilson ,  Raymond Thomas ,  Mark Spatz ,  David Metcalf

IPC分类号： F28D5/00 ,  C09K5/00

CPC分类号： C07C19/08 ,  C07C19/10 ,  C07C21/18 ,  C09K3/30 ,  C09K5/044 ,  C09K5/045 ,  C09K2205/106 ,  C09K2205/122 ,  C09K2205/126

摘要： Disclosed are methods of transferring heat to or from a fluid or body comprising causing heat to be transferred to or from a composition comprising at least trans-1,3,3,3-tetrafluorpropene.

摘要翻译： 公开了将热量从流体或体内传递的方法，其包括使热量转移至或至少包含反式1,3,3,3-四氟丙烯的组合物。

公开(公告)号：US20080076673A1

公开(公告)日：2008-03-27

申请号：US11781188

申请日：2007-07-20

申请人： David Wilson ,  Steffen Nock

发明人： David Wilson ,  Steffen Nock

IPC分类号： C40B30/04 ,  C07K1/00 ,  C07K14/00 ,  C12N15/00 ,  C40B50/06 ,  C40B40/10 ,  C12N15/11 ,  C12N5/06

CPC分类号： C12N15/1093 ,  B82Y30/00 ,  C07K14/195 ,  C12N9/0095

摘要： Engineered binding proteins are provided. In some cases, the parent protein corresponding to the engineered protein has a three-layer swiveling β/β/α domain. In other cases, the parent protein corresponding to the engineered protein has a rubredoxin-like fold. At least one portion of the primary sequence of the engineered protein is determined by an engineering scheme. In some case, the engineered protein is characterized by an ability to bind to a compound that the parent protein does not bind. In some cases, the parent protein is derived from a domain of a chaperonin or a rubredoxin. One form of engineering scheme used is a randomization scheme. A method for making libraries of engineered proteins, all based on a single parent protein is provided. Methods to identify proteins that bind to compounds of interest in libraries of engineered libraries are provided. An array of engineered proteins immobilized on a support is provided. Each engineered protein in the array is a chaperonin domain or a rubredoxin that has been subjected to an engineering scheme.

摘要翻译： 提供工程结合蛋白。 在某些情况下，对应于工程化蛋白质的亲本蛋白质具有三层旋转β/β/α结构域。 在其他情况下，对应于工程改造的蛋白质的亲本蛋白具有类似于rubredoxin的折叠。 工程化蛋白质的初级序列的至少一部分由工程方案确定。 在某些情况下，工程改造的蛋白质的特征在于与母体蛋白不结合的化合物结合的能力。 在一些情况下，母体蛋白质衍生自伴侣蛋白或红蛋白的结构域。 使用的一种工程方案是一种随机化方案。 提供了基于单亲蛋白的制备工程蛋白的文库的方法。 提供了在工程化文库库中鉴定与目的化合物结合的蛋白质的方法。 提供固定在载体上的工程蛋白阵列。 阵列中的每种工程化蛋白质都是经过工程方案的伴侣蛋白结构域或红霉素。

公开(公告)号：US20070294911A1

公开(公告)日：2007-12-27

申请号：US10573057

申请日：2004-09-24

申请人： David Wilson

发明人： David Wilson

IPC分类号： F26B17/12

CPC分类号： F26B25/12 ,  C10F5/00 ,  F23K1/04 ,  F23K2201/20 ,  F26B17/122 ,  F26B17/126 ,  F26B21/08

摘要： The invention provides a dryer for drying particulate material, comprising at least one substantially vertical elongate container having an upper inlet (56a, 56b) for receiving a charge of moisture containing particulate material; a lower outlet (22) for discharging dried particulate material, whereby said particulate material travels under the influence of gravity from said inlet to said outlet; at least one substantially vertical gas permeable wall (20a, 20b) through which a drying gas can pass to contact said particulate material; said dryer also comprising at least one plenum (48, 50) on an exterior surface of said at least one gas permeable wall, covering ingress (38a) and egress openings within said at least one gas permeable wall.

摘要翻译： 本发明提供了一种用于干燥颗粒材料的干燥器，其包括至少一个基本垂直的细长容器，该容器具有用于接收含有颗粒材料的水分的上入口（56a，56b） 用于排出干燥的颗粒材料的下出口（22），由此所述颗粒材料在重力的作用下从所述入口到所述出口行进; 至少一个基本垂直的可透气的壁（20a，20b），干燥气体可以通过该壁通过以接触所述颗粒材料; 所述干燥器还包括在所述至少一个透气壁的外表面上的至少一个气室（48,50），覆盖所述至少一个透气壁内的入口（38a）和出口。