公开(公告)号：US20120118049A1

公开(公告)日：2012-05-17

申请号：US13158953

申请日：2011-06-13

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N30/00

CPC分类号： B01D53/0446 ,  G01N30/463 ,  G01N30/465 ,  G01N30/6095 ,  G01N30/62 ,  G01N30/72 ,  G01N2030/328 ,  Y10T137/877

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device configured to provide three-way switching or switching between three or more inputs or outputs. The microfluidic device can be fluidically coupled to one or more switching valves to provide for selective control of fluid flow in the chromatography system.

摘要翻译： 本文描述的某些实施例涉及包括配置成在三个或更多个输入或输出之间提供三路切换或切换的微流体装置的色谱系统。 微流体装置可以流体耦合到一个或多个切换阀，以提供色谱系统中流体流动的选择性控制。

公开(公告)号：US07422625B2

公开(公告)日：2008-09-09

申请号：US11852655

申请日：2007-09-10

申请人： Andrew Tipler ,  Neil T. Plant

发明人： Andrew Tipler ,  Neil T. Plant

IPC分类号： B01D53/02

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a unit flow per unit pressure based on a ratio of the flow rate and the differential pressure. In certain embodiments, the flow rate at the outlet is established by controlling the flow rate of the gas. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

摘要翻译： 所公开的系统和方法包括提供具有入口和出口的容器，用于使载气通过该容器; 确定出口处的已知流速的入口和出口之间的压差; 并且基于流量和压差的比率确定单位压力的单位流量。 在某些实施例中，通过控制气体的流量来建立出口处的流量。 在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于在输出处的气体压力与环境压力的比率的因子确定环境压力下的流速，和/或确定 使用基于输出温度和环境温度的比率的因子的环境温度。

公开(公告)号：US20080105033A1

公开(公告)日：2008-05-08

申请号：US11841054

申请日：2007-08-20

申请人： Andrew Tipler ,  James Botelho ,  Avinash Dalmia ,  Michael Rafa ,  John Vanderhoef ,  Paul Schallis ,  Neal Green ,  David Scott ,  John McCaffrey ,  Paul St. Cyr ,  E. McCorkle ,  Guiseppe Coppola

发明人： Andrew Tipler ,  James Botelho ,  Avinash Dalmia ,  Michael Rafa ,  John Vanderhoef ,  Paul Schallis ,  Neal Green ,  David Scott ,  John McCaffrey ,  Paul St. Cyr ,  E. McCorkle ,  Guiseppe Coppola

IPC分类号： G01N30/04

CPC分类号： G01N30/30 ,  G01N2030/3076 ,  G01N2030/3084

摘要： A gas chromatography system comprising a sample introduction device, an oven coupled to the sample introduction device and a detector coupled to the oven is disclosed. In certain examples, the oven may be configured to receive a chromatography column in a space in the oven. In some examples, the oven may be constructed and arranged to provide a substantially constant temperature to the space during an analysis stage of the gas chromatography system.

摘要翻译： 公开了一种气相色谱系统，其包括样品引入装置，耦合到样品引入装置的烘箱和耦合到烘箱的检测器。 在某些实例中，烘箱可以被配置成在烘箱的空间中接收色谱柱。 在一些实例中，烘箱可以被构造和布置成在气相色谱系统的分析阶段期间向空间提供基本恒定的温度。

公开(公告)号：US07267709B2

公开(公告)日：2007-09-11

申请号：US11559760

申请日：2006-11-14

申请人： Andrew Tipler ,  Neil T. Plant

发明人： Andrew Tipler ,  Neil T. Plant

IPC分类号： B01D53/02

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an adsorbent disposed therein, the vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a geometric measure for the vessel based on a ratio of the known flow rate and the differential pressure. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

摘要翻译： 公开了包括提供其中设置有吸附剂的容器的系统和方法，所述容器具有用于使载气通过容器连通的入口和出口; 确定出口处的已知流速的入口和出口之间的压差; 并且基于已知流量和压差的比率确定容器的几何度量。 在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于输出处的气体压力和环境压力的比率的因子确定环境压力下的流速，和/或确定 使用基于输出温度和环境温度的比率的因子的环境温度。

公开(公告)号：US07111494B2

公开(公告)日：2006-09-26

申请号：US11072829

申请日：2005-03-04

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N30/02

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an adsorbent disposed therein, the vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a geometric measure for the vessel based on a ratio of the known flow rate and the differential pressure. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

摘要翻译： 公开了包括提供其中设置有吸附剂的容器的系统和方法，所述容器具有用于使载气通过容器连通的入口和出口; 确定出口处的已知流速的入口和出口之间的压差; 并且基于已知流量和压差的比率确定容器的几何度量。 在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于输出处的气体压力和环境压力的比率的因子确定环境压力下的流速，和/或确定 使用基于输出温度和环境温度的比率的因子的环境温度。

公开(公告)号：US06974495B2

公开(公告)日：2005-12-13

申请号：US10954784

申请日：2004-09-30

申请人： Andrew Tipler ,  Gary Campbell ,  Mark Collins

发明人： Andrew Tipler ,  Gary Campbell ,  Mark Collins

IPC分类号： G01N1/22 ,  G01N30/12 ,  B01D15/08 ,  B01D53/04

CPC分类号： B01D53/025 ,  B01D2253/102 ,  G01N30/12 ,  G01N2001/2229 ,  G01N2030/085 ,  G01N2030/121 ,  G01N2030/127 ,  G01N2030/128

摘要： An analyte pre-concentrator for gas chromatography is disclosed generally comprising a tube having a restricted outlet and packed with an adsorbent, wherein the tube serves as the liner of a chromatographic injector, as an adsorbent trap coupled to a chromatographic column, and/or as an adsorbent trap coupled to a headspace sampler. Preferably, a heating device allows the tube to be heated. In a preferred embodiment, the analyte pre-concentrator further comprises a column isolating accessory so that a chromatographic column can be temporarily isolated from substances flowing through the tube.

公开(公告)号：US20150013770A1

公开(公告)日：2015-01-15

申请号：US14275334

申请日：2014-05-12

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： F17D5/00

CPC分类号： G01N30/32 ,  G01N30/20 ,  G01N30/28 ,  G01N30/466 ,  G01N30/468 ,  G01N30/6095 ,  G01N30/72 ,  G01N30/7206 ,  G01N2030/208 ,  G01N2030/324 ,  G01N2030/328 ,  Y10T29/49 ,  Y10T137/0318

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.

摘要翻译： 本文所述的某些实施方案涉及包括微流体装置的色谱系统。 微流体装置可以流体耦合到切换阀，以提供色谱系统中流体流动的选择性控制。 在一些示例中，微流体装置可以包括充电室，旁路限流器或可以提供对系统中的流体流的附加控制的其它特征。 还描述了使用这些装置的方法和计算长度和直径以提供期望流速的方法。

公开(公告)号：US08721768B2

公开(公告)日：2014-05-13

申请号：US13657079

申请日：2012-10-22

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： B01D53/02

CPC分类号： G01N30/32 ,  G01N30/20 ,  G01N30/28 ,  G01N30/466 ,  G01N30/468 ,  G01N30/6095 ,  G01N30/72 ,  G01N30/7206 ,  G01N2030/208 ,  G01N2030/324 ,  G01N2030/328 ,  Y10T29/49 ,  Y10T137/0318

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.

摘要翻译： 本文所述的某些实施方案涉及包括微流体装置的色谱系统。 微流体装置可以流体耦合到切换阀，以提供色谱系统中流体流动的选择性控制。 在一些示例中，微流体装置可以包括充电室，旁路限流器或可以提供对系统中的流体流的附加控制的其它特征。 还描述了使用这些装置的方法和计算长度和直径以提供期望流速的方法。

公开(公告)号：US08562837B2

公开(公告)日：2013-10-22

申请号：US13238882

申请日：2011-09-21

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： B01D15/08

CPC分类号： G01N30/40 ,  G01N30/32 ,  G01N30/463 ,  G01N30/465 ,  G01N30/468 ,  G01N30/6095 ,  G01N2030/402 ,  G01N2030/445 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T137/877

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device and that implement one or more methods to direct sample to a desired fluid flow path. The methods can be used to backflush a sample to a desired fluid flow path to select certain analytes within a sample.

摘要翻译： 本文描述的某些实施例涉及包括微流体装置并且实施一种或多种方法以将样品引导至期望的流体流动路径的色谱系统。 这些方法可用于将样品反吹到所需的流体流动路径以选择样品中的某些分析物。

公开(公告)号：US20100101411A1

公开(公告)日：2010-04-29

申请号：US12472948

申请日：2009-05-27

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N30/38 ,  B01D53/02 ,  G01N30/02 ,  B01D15/08 ,  G06F7/552 ,  G06F7/544

CPC分类号： G01N30/32 ,  G01N30/20 ,  G01N30/28 ,  G01N30/466 ,  G01N30/468 ,  G01N30/6095 ,  G01N30/72 ,  G01N30/7206 ,  G01N2030/208 ,  G01N2030/324 ,  G01N2030/328 ,  Y10T29/49 ,  Y10T137/0318

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.

摘要翻译： 本文所述的某些实施方案涉及包括微流体装置的色谱系统。 微流体装置可以流体耦合到切换阀，以提供色谱系统中流体流动的选择性控制。 在一些示例中，微流体装置可以包括充电室，旁路限流器或可以提供对系统中的流体流的附加控制的其它特征。 还描述了使用这些装置的方法和计算长度和直径以提供期望流速的方法。