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公开(公告)号：US06759414B2
公开(公告)日：2004-07-06
申请号：US10629760
申请日：2003-07-29
申请人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milet , Marta Maria Piñeiro-Nuñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milet , Marta Maria Piñeiro-Nuñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K315501
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：US06710057B2
公开(公告)日：2004-03-23
申请号：US10377906
申请日：2003-02-28
申请人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K314545
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译： 本申请涉及如本文所定义的式I化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。
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公开(公告)号：US06635657B1
公开(公告)日：2003-10-21
申请号：US09857751
申请日：2001-06-08
申请人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K314545
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译： 本申请涉及如本文所定义的式I化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。
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公开(公告)号：US06610704B1
公开(公告)日：2003-08-26
申请号：US09857747
申请日：2001-06-08
申请人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Pineiro-Nunez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Pineiro-Nunez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： C07D21302
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermidates thereof.
摘要翻译： 本申请涉及如本文所定义的式（I）化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。
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公开(公告)号：US20050282862A1
公开(公告)日：2005-12-22
申请号：US10629817
申请日：2003-07-29
申请人： Douglas Beight , Trelia Craft , Carl Denny , Jeffry Franciskovich , Theodore Goodson , Steven Hall , David Herron , Sajan Joseph , Valentine Klimkowski , Jeffrey Kyle , John Masters , David Mendel , Guy Milot , Marta Pineiro-Nunez , Jason Sawyer , Robert Shuman , Gerald Smith , Anne Tebbe , Jennifer Tinsley , Leonard Weir , James Wikel , Michael Wiley , Ying Yee
发明人： Douglas Beight , Trelia Craft , Carl Denny , Jeffry Franciskovich , Theodore Goodson , Steven Hall , David Herron , Sajan Joseph , Valentine Klimkowski , Jeffrey Kyle , John Masters , David Mendel , Guy Milot , Marta Pineiro-Nunez , Jason Sawyer , Robert Shuman , Gerald Smith , Anne Tebbe , Jennifer Tinsley , Leonard Weir , James Wikel , Michael Wiley , Ying Yee
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P7/02 , A61P9/10 , C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D41/02
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译： 本申请涉及如本文所定义的式I化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。
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公开(公告)号：US06867198B2
公开(公告)日：2005-03-15
申请号：US10130493
申请日：2000-12-18
申请人： Rima Salim Al-Awar , Kyle Andrew Hecker , James Edward Ray , Jianping Huang , Sajan Joseph , Tiechao Li , Michael Paal , Radhakrishnan Rathnachalam , Chuan Shih , Philip Parker Waid , Xun Zhou , Guoxin Zhu
发明人： Rima Salim Al-Awar , Kyle Andrew Hecker , James Edward Ray , Jianping Huang , Sajan Joseph , Tiechao Li , Michael Paal , Radhakrishnan Rathnachalam , Chuan Shih , Philip Parker Waid , Xun Zhou , Guoxin Zhu
IPC分类号： C07D471/06 , C07D471/22 , C07D487/06 , C07D487/22 , C07D513/06 , C07D513/22 , C07F7/18 , C07H15/252 , A61K31/435 , A61K31/445
CPC分类号： C07D471/06 , C07D487/06 , C07D513/06 , C07F7/1804 , C07H15/252
摘要： The present invention provides selective kinase inhibitors of formula (I)
摘要翻译： 本发明提供了式（I）的选择性激酶抑制剂，
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公开(公告)号：US08148387B2
公开(公告)日：2012-04-03
申请号：US12611139
申请日：2009-11-03
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04 , C07D473/34
摘要： The present invention provides AKT and p70 S6 kinase inhibitors of the formula: The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and methods of using compounds of Formula I.
摘要翻译： 本发明提供下式的AKT和p70 S6激酶抑制剂：本发明还提供包含式I化合物的药物组合物，式I化合物的用途和使用式I化合物的方法。
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公开(公告)号：US20120071490A1
公开(公告)日：2012-03-22
申请号：US13307560
申请日：2011-11-30
IPC分类号： A61K31/519 , A61P35/00 , A61K31/52 , C07D487/04 , C07D473/32
CPC分类号： C07D487/04
摘要： The present invention provides p70 S6 kinase inhibitors of the formula: pharmaceutical formulations comprising them, and methods for their use.
摘要翻译： 本发明提供下式的p70 S6激酶抑制剂：包含它们的药物制剂及其使用方法。
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公开(公告)号：US07414063B2
公开(公告)日：2008-08-19
申请号：US10547969
申请日：2004-03-25
申请人： Rima Salim Al-Awar , David Anthony Barda , Albert Gerard Dee , Kenneth James Henry, Jr. , Sajan Joseph , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett , Carmen Somoza
发明人： Rima Salim Al-Awar , David Anthony Barda , Albert Gerard Dee , Kenneth James Henry, Jr. , Sajan Joseph , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett , Carmen Somoza
IPC分类号： C07D217/02 , A61K31/47
CPC分类号： C07D401/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12 , C07D413/02 , C07D413/12
摘要： The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译： 本发明涉及式（I）化合物：作为AKT活性的抑制剂，其可用于治疗易感性肿瘤和病毒感染。
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公开(公告)号：US09067920B2
公开(公告)日：2015-06-30
申请号：US13877923
申请日：2011-11-01
申请人： Sajan Joseph , Susanta Samajdar
发明人： Sajan Joseph , Susanta Samajdar
IPC分类号： C07D401/14 , A61K31/497 , A61K31/704 , A61K31/7068 , C07C53/10 , C07C55/07 , C07C55/10 , C07C309/04
CPC分类号： C07D401/14 , A61K31/497 , A61K31/704 , A61K31/7068 , C07C53/10 , C07C55/07 , C07C55/10 , C07C309/04
摘要： The present invention provides an aminopyrazole compound, or a pharmaceutically acceptable salt thereof, that inhibits Chk1 and is useful in the treatment of cancer.
摘要翻译： 本发明提供抑制Chk1并可用于治疗癌症的氨基吡唑化合物或其药学上可接受的盐。
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