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11.发明授权Antibodies directed against amyloid-beta peptide and nucleic acids encoding same 失效针对淀粉样蛋白-β肽的抗体和编码相同的核酸的抗体公开(公告)号：US07763250B2
公开(公告)日：2010-07-27
申请号：US11413817
申请日：2006-04-28
申请人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho
发明人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/28 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Antibodies directed to the C-terminal side of β-amyloid peptide and methods of using these antibodies for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described.
摘要翻译： 针对β-淀粉样蛋白肽的C-末端的抗体以及使用这些抗体诊断和治疗阿尔茨海默病和A＆bgr的方法; 描述了肽相关疾病。
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公开(公告)号：US08586045B2
公开(公告)日：2013-11-19
申请号：US13179846
申请日：2011-07-11
申请人： Joerg Zeller , Kristian T. Poulsen , Yasmina Noubia Abdiche , Jaume Pons , Sierra Lee Jones Collier , Arnon Rosenthal
发明人： Joerg Zeller , Kristian T. Poulsen , Yasmina Noubia Abdiche , Jaume Pons , Sierra Lee Jones Collier , Arnon Rosenthal
IPC分类号： A61K39/395 , C12P21/08 , C07K16/00
CPC分类号： C07K16/18 , A61K31/4045 , A61K39/3955 , A61K2039/505 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
摘要翻译： 本发明的特征在于通过施用抗CGRP拮抗剂抗体来预防或治疗CGRP相关疾病如血管舒缩症状，包括头痛（例如偏头痛，丛集性头痛和紧张性头痛）和热潮红的方法。 还描述了拮抗剂抗体G1和衍生自指向CGRP的G1的抗体。
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13.发明申请ANTAGONIST ANTIBODIES DIRECTED AGAINST CALCITONIN GENE-RELATED PEPTIDE AND METHODS USING SAME 有权针对CALCITONIN基因相关肽的ANTAGONIST抗体及其使用方法公开(公告)号：US20120009192A1
公开(公告)日：2012-01-12
申请号：US13179846
申请日：2011-07-11
申请人： Joerg Zeller , Kristian T. Poulsen , Yasmina N. Abdiche , Jaume Pons , Sierra Leigh Jones Collier , Arnon Rosenthal
发明人： Joerg Zeller , Kristian T. Poulsen , Yasmina N. Abdiche , Jaume Pons , Sierra Leigh Jones Collier , Arnon Rosenthal
CPC分类号： C07K16/18 , A61K31/4045 , A61K39/3955 , A61K2039/505 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
摘要翻译： 本发明的特征在于通过施用抗CGRP拮抗剂抗体来预防或治疗CGRP相关疾病如血管舒缩症状，包括头痛（例如偏头痛，丛集性头痛和紧张性头痛）和热潮红的方法。 还描述了拮抗剂抗体G1和衍生自指向CGRP的G1的抗体。
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公开(公告)号：US08088384B2
公开(公告)日：2012-01-03
申请号：US12618896
申请日：2009-11-16
申请人： Jaume Pons , Arnon Rosenthal
发明人： Jaume Pons , Arnon Rosenthal
IPC分类号： A61K39/395 , A61P19/02 , C07K16/00 , C12P21/06
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译： 本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）和编码该抗体的多核苷酸。 本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。
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公开(公告)号：US09212222B2
公开(公告)日：2015-12-15
申请号：US13302264
申请日：2011-11-22
申请人： Jaume Pons , Arnon Rosenthal
发明人： Jaume Pons , Arnon Rosenthal
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
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公开(公告)号：US20100111970A1
公开(公告)日：2010-05-06
申请号：US12618896
申请日：2009-11-16
申请人： Jaume Pons , Arnon Rosenthal
发明人： Jaume Pons , Arnon Rosenthal
IPC分类号： A61K39/395 , C07K16/00 , C12P21/06 , A61P19/02
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译： 本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）和编码该抗体的多核苷酸。 本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。
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公开(公告)号：US20090203610A1
公开(公告)日：2009-08-13
申请号：US12404202
申请日：2009-03-13
IPC分类号： A61K38/12
CPC分类号： A61K38/185
摘要： The invention concerns methods for treating obesity, non-insulin dependent diabetes mellitus, metabolic syndrome, and other related diseases by administering an NT-4/5 polypeptide. The invention also concerns compositions and kits comprising an NT-4/5 polypeptide.
摘要翻译： 本发明涉及通过施用NT-4/5多肽来治疗肥胖症，非胰岛素依赖性糖尿病，代谢综合征和其它相关疾病的方法。 本发明还涉及包含NT-4/5多肽的组合物和试剂盒。
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公开(公告)号：US20050209148A1
公开(公告)日：2005-09-22
申请号：US11064309
申请日：2005-02-22
申请人： Arnon Rosenthal , John Lin , Jennifer Stratton , Robert Klein , Jaume Pons
发明人： Arnon Rosenthal , John Lin , Jennifer Stratton , Robert Klein , Jaume Pons
CPC分类号： A61K38/185
摘要： The invention concerns methods for treating obesity, non-insulin dependent diabetes mellitus, metabolic syndrome, and other related diseases by administering an NT-4/5 polypeptide. The invention also concerns compositions and kits comprising an NT-4/5 polypeptide.
摘要翻译： 本发明涉及通过施用NT-4/5多肽来治疗肥胖症，非胰岛素依赖性糖尿病，代谢综合征和其它相关疾病的方法。 本发明还涉及包含NT-4/5多肽的组合物和试剂盒。
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公开(公告)号：US20070212357A1
公开(公告)日：2007-09-13
申请号：US11653206
申请日：2007-01-12
申请人： Jaume Pons , Arnon Rosenthal
发明人： Jaume Pons , Arnon Rosenthal
IPC分类号： A61K39/395 , C07K16/22 , C12P21/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译： 本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）和编码该抗体的多核苷酸。 本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。
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20.发明授权Antagonist antibodies directed against calcitonin gene-related peptide and methods using same 有权针对降钙素基因相关肽的拮抗剂抗体及使用其的方法公开(公告)号：US08007794B2
公开(公告)日：2011-08-30
申请号：US12093638
申请日：2006-11-02
申请人： Joerg Zeller , Kristian T. Poulsen , Yasmina Noubia Abdiche , Jaume Pons , Sierra Leigh Jones Collier , Arnon Rosenthal
发明人： Joerg Zeller , Kristian T. Poulsen , Yasmina Noubia Abdiche , Jaume Pons , Sierra Leigh Jones Collier , Arnon Rosenthal
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K31/4045 , A61K39/3955 , A61K2039/505 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
摘要翻译： 本发明的特征在于通过施用抗CGRP拮抗剂抗体来预防或治疗CGRP相关疾病如血管舒缩症状，包括头痛（例如偏头痛，丛集性头痛和紧张性头痛）和热潮红的方法。 还描述了拮抗剂抗体G1和衍生自指向CGRP的G1的抗体。
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