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公开(公告)号：US07135342B2
公开(公告)日：2006-11-14
申请号：US10137329
申请日：2002-05-03
IPC分类号： G01N21/00
CPC分类号： G01N21/77 , G01N21/6428 , G01N21/783 , G01N2021/6432 , G01N2021/7786 , G01N2021/7793 , G01N2021/7796 , Y10T436/144444
摘要： An electro-optical sensing device for detecting the presence and concentration of an analyte in a liquid or gaseous medium includes a pair of indicator elements positioned to receive radiation from a radiation source and transmit radiation to a pair of photosensitive elements. The indicator elements each contain indicator molecules having an optical characteristic responsive to the presence of an analyte; however, one of the indicator elements is covered by an analyte-impermeable chamber that renders the indicator element insensitive to the presence of the analyte in the medium outside the chamber so that it can be used as a reference to cancel environmental and systemic variables that affect both indicator elements. The chamber preferably holds an analyte-containing fluid in contact with the reference indicator element so that the indicator elements operate under nominally identical conditions. The indicator element used to measure the analyte in the external medium is preferably also covered, but in a manner that provides direct contact between the analyte and the indicator element.
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公开(公告)号：US08233953B2
公开(公告)日：2012-07-31
申请号：US11925272
申请日：2007-10-26
IPC分类号： A61B5/1455
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6861 , A61B2560/0219 , A61B2562/12 , G01N21/552 , G01N21/6428 , G01N21/648 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , Y10S128/903
摘要： An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.
摘要翻译： 一种光学传感器，用于使用指示器和参考通道来检测分析物的存在或量。 该传感器具有一个传感器体，其中嵌有辐射源。 源发射的辐射与靠近身体表面的指示剂膜指示剂分子相互作用。 这些指示剂分子的至少一种光学特性随分析物浓度而变化。 例如，荧光指示剂分子的荧光水平或光吸收指示剂分子吸收的光量可以作为分析物浓度的函数而变化。 此外，源发射的辐射也与靠近身体表面的参考膜指示剂分子相互作用。 由这些指示剂分子发射或反射的辐射（例如，光）进入并在内部反射在传感器主体中。 传感器体内的感光元件产生指示通道和参考通道信号，以提供分析物浓度的准确指示。 优选的实施方案是完全独立的并且其尺寸和形状用于人体内的体内。 这样的实施例优选地包括电源，例如电源。 电感器，其使用外部装置为辐射源供电，以及发射器，例如， 电感器，用于向外部拾取装置传输表示分析物水平的信号。
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公开(公告)号：US5917605A
公开(公告)日：1999-06-29
申请号：US855236
申请日：1997-05-13
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/7703 , G01N2021/6484
摘要： A fluorescence sensing device for determining the presence or concentration of an analyte in a liquid or gaseous medium is constructed of a fiber optic plate comprising optical fibers having relatively small numerical apertures. The fiber optic plate is positioned on a photodetector and has a layer of analyte permeable fluorescent matrix or coated waveguide material on its top surface. The fluorescent matrix or waveguide coating contains indicator molecules whose fluorescence is affected by the local presence of analyte. A light source emits light into the fluorescent matrix in a direction generally parallel to the top surface of the fiber optic plate. Upon absorbing light from the light source, indicator molecules in the fluorescent matrix emit fluorescent light which is transmitted through the fiber optic plate to the photodetector.
摘要翻译： 用于确定液体或气体介质中分析物的存在或浓度的荧光检测装置由包括具有相对较小数值孔径的光纤的光纤板构成。 光纤板位于光电检测器上，并且在其顶表面上具有分析物可渗透的荧光矩阵或涂覆的波导材料层。 荧光基质或波导涂层含有指示剂分子，其荧光受到分析物局部存在的影响。 光源在大致平行于光纤板的顶表面的方向上将光发射到荧光矩阵中。 在从光源吸收光时，荧光矩阵中的指示剂分子发射荧光，其通过光纤板传输到光电检测器。
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公开(公告)号：US4868767A
公开(公告)日：1989-09-19
申请号：US79641
申请日：1987-07-30
IPC分类号： G01N21/86
CPC分类号： G01N21/8483 , G01N2201/124 , G01N2201/126
摘要： Apparatus and method are disclosed for detecting the presence of a analyte in a sample. The apparatus includes an optical transmitter and receiver for transmitting light toward the sample and receiving a portion of the reflected light. The optical receiver acts in conjunction with a data processor to convert the reflected light to data representing the density of analyte in the sample. The apparatus thus disclosed is portable and can be transported to remote testing sites.
摘要翻译： 公开了用于检测样品中分析物的存在的装置和方法。 该装置包括用于向样品发射光并接收一部分反射光的光发射器和接收器。 光学接收器与数据处理器结合操作，将反射光转换为表示样品中分析物密度的数据。 所公开的装置是便携式的，并且可以被运送到远程测试地点。
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公开(公告)号：US09681824B2
公开(公告)日：2017-06-20
申请号：US13421013
申请日：2012-03-15
申请人： Arthur E. Colvin, Jr. , Hui Jiang
发明人： Arthur E. Colvin, Jr. , Hui Jiang
IPC分类号： A61B5/1455 , A61B5/07 , A61B5/145 , A61B5/1459
CPC分类号： A61B5/076 , A61B5/145 , A61B5/14532 , A61B5/1459 , A61B2562/028 , A61B2562/162 , A61B2562/18
摘要： An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.
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公开(公告)号：US08143068B2
公开(公告)日：2012-03-27
申请号：US12966693
申请日：2010-12-13
CPC分类号： G01N33/66 , C07F5/025 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , Y10T436/144444
摘要： Compounds having enhanced oxidation stability are disclosed. The compounds have an aryl boronic acid residue having one or more electron withdrawing groups on the aromatic moiety which contains the boronic acid residue, such that the molecule has enhanced oxidation resistance as compared to a corresponding molecule without the one or more electron withdrawing groups.
摘要翻译： 公开了具有增强的氧化稳定性的化合物。 所述化合物在芳族部分上具有一个或多个吸电子基团的芳基硼酸残基，其含有硼酸残基，使得与没有一个或多个吸电子基团的相应分子相比，该分子具有增强的抗氧化性。
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公开(公告)号：US07060503B2
公开(公告)日：2006-06-13
申请号：US10788264
申请日：2004-03-01
IPC分类号： G01N33/00
CPC分类号： G01N21/6428 , A61B5/14532 , A61B5/1459 , C07D257/02 , G01N31/22 , G01N33/542 , G01N33/66 , G01N33/84 , G01N2021/6432 , G01N2021/7786 , Y10T436/143333 , Y10T436/144444
摘要： The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.
摘要翻译： 本发明涉及用于检测介质如液体中分析物的存在或浓度的指示剂分子以及用于实现这种检测的方法。 更具体地，本发明涉及含有相对疏水的指示剂组分单体和亲水单体的共聚物大分子，使得大分子能够在水性环境中使用。
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公开(公告)号：US5910661A
公开(公告)日：1999-06-08
申请号：US855235
申请日：1997-05-13
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/648 , G01N21/7703
摘要： A fluorescence sensing device for determining the presence or concentration of an analyte in a liquid or gaseous medium is constructed of an optical filter, which is positioned on a photodetector and which has a thin film of analyte-permeable, fluorescent indicator molecule-containing material on its top surface. An edge-emitting, light-emitting P-N junction is positioned on the top surface of the optical filter such that the P-N junction from which light is emitted is positioned within the film. Light emitted by the fluorescent indicator molecules impacts the photodetector thereby generating an electrical signal that is related to the concentration of the analyte in the liquid or gaseous medium. Fluorescence sensing devices according to this invention are characterized by very compact sizes, fast response times and high signal-to-noise ratios.
摘要翻译： 用于确定液体或气体介质中分析物的存在或浓度的荧光检测装置由位于光电检测器上的光学滤光器构成，该滤光器具有分析物可透过的含荧光指示剂分子的材料薄膜 其顶面。 边缘发射的发光P-N结位于光滤波器的顶表面上，使得发射光的P-N结位于膜内。 由荧光指示剂分子发射的光影响光电检测器，从而产生与液体或气体介质中分析物浓度相关的电信号。 根据本发明的荧光感测装置的特征在于非常紧凑的尺寸，快速的响应时间和高的信噪比。
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公开(公告)号：US5517313A
公开(公告)日：1996-05-14
申请号：US393166
申请日：1995-02-21
CPC分类号： G01N21/6428 , G01N2021/7786
摘要： A fluorescence sensor for detecting the presence and amount of an analyte. The fluorescence sensor has a photodetector, a high pass filter located adjacent the photodetector, and a glass layer located adjacent the high pass filter. An indicator layer is located adjacent the glass layer and a light emitting diode is embedded in the indicator layer. The indicator layer has indicator molecules that provide a fluorescent emission as a result of light from the light emitting diode. The indicator layer also allows an analyte to diffuse into it and the presence of the analyte reduces the amount of light emitted from the indicator molecules that passes through the glass layer and the high pass filter and is incident upon the photodetector. Since the amount of current from the photodetector depends upon the incident light, this is used to detect the presence and amount of the analyte. In one embodiment a waveguide is also present.
摘要翻译： 用于检测分析物的存在和量的荧光传感器。 荧光传感器具有光电检测器，位于光电检测器附近的高通滤波器和位于高通滤波器附近的玻璃层。 指示层位于玻璃层附近，发光二极管嵌入在指示层中。 指示剂层具有作为来自发光二极管的光的结果提供荧光发射的指示剂分子。 指示剂层还允许分析物扩散到其中，并且分析物的存在减少了从通过玻璃层和高通滤波器并且入射到光电检测器上的指示剂分子发射的光的量。 由于来自光电检测器的电流量取决于入射光，所以用于检测分析物的存在和量。 在一个实施例中也存在波导。
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公开(公告)号：US10662333B2
公开(公告)日：2020-05-26
申请号：US16308675
申请日：2017-06-16
摘要： The invention relates to a porphyrin time domain indicator. The indicator may be used for detection of a particular analyte in vivo or in vitro. The indicator may be used for detection of glucose in vivo or in vitro.
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