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11.发明申请公开(公告)号：US20120214802A1
公开(公告)日：2012-08-23
申请号：US13259091
申请日：2009-10-09
申请人： Geoffrey M. Bilcer , Thippeswamy Devasamudram , Sudha V. Ankala , John C. Lilly , Chunfeng Liu , Hui Lei , Arun K. Ghosh , Makoto Inoue
发明人： Geoffrey M. Bilcer , Thippeswamy Devasamudram , Sudha V. Ankala , John C. Lilly , Chunfeng Liu , Hui Lei , Arun K. Ghosh , Makoto Inoue
IPC分类号： A61K31/427 , A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/40 , C07D417/14 , C07D413/12 , C07D207/16 , C07D207/09 , C07D417/12 , C07D413/14 , A61P25/28 , C12N9/99
CPC分类号： A61K31/16 , A61K31/195 , A61K31/40 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
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12.发明申请(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING 失效（3-羟基-4-氨基 - 丁-2-炔基）-3-（2-噻唑-2-基） - 吡咯烷-1-羰基]苯甲酰胺衍生物及相关化合物作为用于治疗的β-分泌酶抑制剂公开(公告)号：US20100286170A1
公开(公告)日：2010-11-11
申请号：US12677748
申请日：2008-09-24
申请人： Arun K. Ghosh , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa M. Swanson , Sudha V. Ankala , John C. Lilly , Geoffrey M. Bilcer
发明人： Arun K. Ghosh , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa M. Swanson , Sudha V. Ankala , John C. Lilly , Geoffrey M. Bilcer
IPC分类号： A61K31/497 , C07D417/14 , C07D417/04 , C07D401/10 , C07D207/08 , C07D413/04 , C07D413/14 , C12N9/99 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/427 , A61K31/40 , A61K31/422 , A61P25/28
CPC分类号： C07D417/14 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
摘要翻译： 本发明提供新颖的β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默氏病的方法。
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公开(公告)号：US20070117793A1
公开(公告)日：2007-05-24
申请号：US11463558
申请日：2006-08-09
申请人： Arun Ghosh , Nagaswamy Kumaragurubaran , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa Swanson , Sudha Ankala , Jordan Tang , Geoffrey Bilcer
发明人： Arun Ghosh , Nagaswamy Kumaragurubaran , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa Swanson , Sudha Ankala , Jordan Tang , Geoffrey Bilcer
IPC分类号： A61K31/551 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/473 , A61K31/4709 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4184
CPC分类号： C07D213/74 , C07C233/78 , C07C311/08 , C07C311/29 , C07C2601/14 , C07D207/09 , C07D209/14 , C07D211/26 , C07D213/36 , C07D213/40 , C07D213/61 , C07D213/65 , C07D215/12 , C07D233/64 , C07D235/14 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D295/108 , C07D295/13 , C07D295/205 , C07D295/32 , C07D307/52 , C07D307/62 , C07D309/04 , C07D317/58 , C07D417/12 , C07D493/04
摘要： The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
摘要翻译： 本发明提供新颖的β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默氏病的方法。
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14.发明申请公开(公告)号：US20050239684A1
公开(公告)日：2005-10-27
申请号：US10944117
申请日：2004-09-17
申请人： Arun Ghosh , Jordan Tang , Hui Lei , Thippeswamy Devasamudram , Chunfeng Liu , Geoffrey Bilcer
发明人： Arun Ghosh , Jordan Tang , Hui Lei , Thippeswamy Devasamudram , Chunfeng Liu , Geoffrey Bilcer
IPC分类号： A61K38/00 , A61P25/28 , C07D207/16 , C07D213/30 , C07D213/40 , C07D215/14 , C07D215/36 , C07D215/54 , C07D307/14 , C07D307/16 , C07D307/20 , C07D307/93 , C07D493/04 , C07D521/00 , C07K5/03 , C07K7/02 , C07K14/00 , C07K14/47 , A61K38/17
CPC分类号： C07D307/93 , C07D207/16 , C07D213/30 , C07D213/40 , C07D215/14 , C07D215/36 , C07D215/54 , C07D231/12 , C07D233/56 , C07D249/08 , C07D307/14 , C07D307/16 , C07D307/20 , C07D493/04
摘要： The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
摘要翻译： 本发明提供新颖的β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默氏病的方法。
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公开(公告)号：US07157489B2
公开(公告)日：2007-01-02
申请号：US10382435
申请日：2003-03-06
IPC分类号： C07D493/04 , C07D493/10 , A61K31/401 , C07D307/93
CPC分类号： C07D213/70 , A61K31/34 , A61K31/35 , A61K45/06 , C07C311/29 , C07C311/41 , C07D209/96 , C07D307/20 , C07D307/935 , C07D307/94 , C07D317/44 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D419/12 , C07D491/10 , C07D493/04 , A61K2300/00
摘要： Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed.
摘要翻译： 公开了可用于抑制HIV蛋白酶的化合物。 还公开了制备化合物的方法及其作为治疗剂的用途，例如用于治疗野生型HIV和HIV耐药多药耐药菌株。
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公开(公告)号：US07897635B2
公开(公告)日：2011-03-01
申请号：US11593665
申请日：2006-11-07
IPC分类号： C07D493/04 , C07D493/10 , A61K31/401
CPC分类号： C07D213/70 , A61K31/34 , A61K31/35 , A61K45/06 , C07C311/29 , C07C311/41 , C07D209/96 , C07D307/20 , C07D307/935 , C07D307/94 , C07D317/44 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D419/12 , C07D491/10 , C07D493/04 , A61K2300/00
摘要： Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed.
摘要翻译： 公开了可用于抑制HIV蛋白酶的化合物。 还公开了制备化合物的方法及其作为治疗剂的用途，例如用于治疗野生型HIV和HIV耐药多药耐药菌株。
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公开(公告)号：US20070082883A1
公开(公告)日：2007-04-12
申请号：US11593665
申请日：2006-11-07
IPC分类号： A61K31/5375 , A61K31/40 , A61K31/397 , A61K31/343 , A61K31/325
CPC分类号： C07D213/70 , A61K31/34 , A61K31/35 , A61K45/06 , C07C311/29 , C07C311/41 , C07D209/96 , C07D307/20 , C07D307/935 , C07D307/94 , C07D317/44 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D419/12 , C07D491/10 , C07D493/04 , A61K2300/00
摘要： Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed.
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