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    BIOMOLECULE POLYMER CONJUGATES AND METHODS FOR MAKING THE SAME
    12.
    发明申请
    BIOMOLECULE POLYMER CONJUGATES AND METHODS FOR MAKING THE SAME 有权
    生物分子聚合物共混物及其制备方法

    公开(公告)号：US20110294189A1

    公开(公告)日：2011-12-01

    申请号：US13201502

    申请日：2010-02-17

    Applicant: Ashutosh Chilkoti ,  Weiping Gao

    Inventor： Ashutosh Chilkoti ,  Weiping Gao

    IPC: C12N9/96 ,  C07K1/107 ,  C07H1/00 ,  C08F2/00

    CPC classification number: C07K1/1075 ,  A61K38/00 ,  A61K47/60 ,  C07K1/02

    Abstract: Methods for producing biomolecule-polymer conjugates, such as polypeptide-polymer conjugates, include attachment of an initiator agent to a biomolecule and in situ polymerization of a polymer from defined sites on the biomolecule. The conjugates may have desirable pharmacological properties and may be used therapeutically.

    Abstract translation: 用于生产生物分子 - 聚合物缀合物（例如多肽 - 聚合物共轭物）的方法包括将引发剂连接到生物分子上，并且聚合物从生物分子上的限定位点的原位聚合。 缀合物可具有期望的药理学性质并且可以在治疗上使用。

    Elastin-like polypeptide and gadolinium conjugate for magnetic resonance imaging
    14.
    发明申请
    Elastin-like polypeptide and gadolinium conjugate for magnetic resonance imaging 审中-公开
    用于磁共振成像的弹性蛋白样多肽和钆共轭物

    公开(公告)号：US20110110866A1

    公开(公告)日：2011-05-12

    申请号：US12082271

    申请日：2008-04-10

    Applicant: Ashutosh Chilkoti ,  Matthew R. Dreher ,  Daniel E. Meyer ,  Mark W. Dewhirst

    Inventor： Ashutosh Chilkoti ,  Matthew R. Dreher ,  Daniel E. Meyer ,  Mark W. Dewhirst

    IPC: A61K49/14 ,  C07K14/00 ,  A61P35/00 ,  A61P9/10

    CPC classification number: A61K49/14 ,  A61K49/085 ,  Y10T428/2982

    Abstract: A magnetic resonance imaging (MRI) contrast enhancement agent comprising an elastin-like polypeptide (ELP) and one or more paramagnetic metal ions is disclosed. Also disclosed are methods of preparing ELP MRI contrast enhancement agents, formulations comprising ELP MRI contrast enhancement agents, and methods of using ELP MRI contrast enhancement agents to image biological samples and to image and deliver therapeutic agents to targeted sites in vivo. In some embodiments, the ELP MRI agents can be used in methods related to blood volume determination, in magnetic resonance angiography (MRA), and in vascular transport determinations. The ELP MRI contrast agents can also provide information on the expression of various proteins through affinity targeting or enzymatic crosslinking in order to aid in diagnosis and in the spatial definition of pathologic tissue.

    Abstract translation: 公开了包含弹性蛋白样多肽（ELP）和一种或多种顺磁金属离子的磁共振成像（MRI）造影增强剂。 还公开了制备ELP MRI对比度增强剂的方法，包含ELP MRI对比度增强剂的制剂，以及使用ELP MRI对比增强剂来成像生物样品并将治疗剂成像并递送到体内靶向位点的方法。 在一些实施方案中，ELP MRI剂可用于与血容量测定，磁共振血管造影术（MRA）和血管传输测定相关的方法。 ELP MRI造影剂还可以通过亲和力靶向或酶交联提供关于各种蛋白质表达的信息，以帮助诊断和病理组织的空间定义。

    DRUG DELIVERY WITH STIMULUS RESPONSIVE BIOPOLYMERS
    15.
    发明申请
    DRUG DELIVERY WITH STIMULUS RESPONSIVE BIOPOLYMERS 审中-公开
    药物递送与刺激性反应性生物反应器

    公开(公告)号：US20100189643A1

    公开(公告)日：2010-07-29

    申请号：US12374816

    申请日：2007-07-17

    Applicant: Ashutosh Chilkoti ,  Matthew Robert Dreher ,  Daniel Eugene Meyer

    Inventor： Ashutosh Chilkoti ,  Matthew Robert Dreher ,  Daniel Eugene Meyer

    IPC: A61K47/48 ,  A61K49/00 ,  A61K51/00

    CPC classification number: A61K51/088 ,  A61K47/64

    Abstract: The present invention provides conjugate compounds comprising (a) an active compound; (b) optionally, but in some embodiments preferably, an affinity binding agent; and (c) a block copolymer, the block copolymer comprising: (i) a first elastin-like polypeptide having a first Tt and (U) a second elastin-like polypeptide having a second Tt greater than the first Tt. Method for the targeted delivering of an active compound in vivo to a selected region within a subject with such agents are also described.

    Abstract translation: 本发明提供了包含（a）活性化合物的缀合物化合物; （b）任选地，但在一些实施方案中优选地，亲和力结合剂; 和（c）嵌段共聚物，所述嵌段共聚物包含：（i）具有第一Tt的第一弹性蛋白样多肽和（U）具有大于第一Tt的第二Tt的第二弹性蛋白样多肽。 还描述了用这种试剂将活性化合物在体内靶向递送到受试者内的选定区域的方法。

    Methods of using bioelastomers
    16.
    发明授权
    Methods of using bioelastomers 有权
    使用生物弹性体的方法

    公开(公告)号：US07429458B2

    公开(公告)日：2008-09-30

    申请号：US10153753

    申请日：2002-07-23

    Applicant: Ashutosh Chilkoti

    Inventor： Ashutosh Chilkoti

    IPC: G01N33/53

    CPC classification number: B82Y30/00 ,  A61K41/00 ,  A61K47/58 ,  C07K16/1232

    Abstract: Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In general, the bioelastomer is conjugated to a binding compound, which is in turn used to bind a compound of interest. For targeted compound delivery, the bioelastomer is conjugated to the compound to be delivered.

    Abstract translation: 公开了生物弹性体用于结合化合物的方法，包括免疫测定方法，生物传感器和方法或再生生物传感器，以及用于将化合物递送到动物受试者内的特定位置的方法。 通常，生物弹性体与结合化合物缀合，结合化合物又用于结合感兴趣的化合物。 对于靶向化合物递送，生物弹性体与待递送的化合物缀合。

    Ultrasound drug delivery enhancement and imaging systems and methods
    17.
    发明授权
    Ultrasound drug delivery enhancement and imaging systems and methods 有权
    超声药物递送增强和成像系统和方法

    公开(公告)号：US06716168B2

    公开(公告)日：2004-04-06

    申请号：US10136610

    申请日：2002-04-30

    Applicant: Levin Nock ,  Ashutosh Chilkoti ,  Kathryn R. Nightingale ,  Gregg E. Trahey

    Inventor： Levin Nock ,  Ashutosh Chilkoti ,  Kathryn R. Nightingale ,  Gregg E. Trahey

    IPC: A61B800

    CPC classification number: A61M37/0092 ,  A61B2090/378 ,  A61N2007/0078

    Abstract: A method and system for both enhancing drug uptake by application of therapeutic transmissions of acoustic energy and imaging a region for applied therapy with a same transducer and ultrasound system. An ultrasonic image of a field of view is generated while localized delivery of a drug is enhanced with ultrasound energy. Using the same transducer and ultrasound system reduces costs and increases system availability for a broader range of medical practitioners. For example, a single linear array of transducer elements is used for application of both imaging and therapeutic ultrasound. As another example, a transmitter is provided that transmits therapeutic transmissions having substantially equal positive and negative peaks at the face of the transducer and also is operable to transmit imaging acoustic energy. As yet another example, therapeutic pulses of acoustic energy are transmitted to have greater power for heating than imaging, but a mechanical index or pressure comparable to imaging transmissions. For example, a mechanical index of about 1.9 or lower is provided, such that cavitation of blood or other non-contrast agent is avoided.

    Abstract translation: 一种用于通过应用声能的治疗性传播来增强药物摄取的方法和系统，并且用相同的换能器和超声系统对用于应用治疗的区域成像。 产生视野的超声波图像，同时用超声能量增强药物的局部递送。 使用相同的传感器和超声系统可以降低成本，并提高更广泛的医疗从业者的系统可用性。 例如，单个线性阵列的换能器元件用于成像和治疗超声的应用。 作为另一示例，提供了一种发射器，其发射在换能器的表面处具有基本相等的正峰值和负峰值的治疗传播，并且还可操作以传输成像声能。 作为又一个示例，声能的治疗脉冲被传输以具有比成像更大的加热功率，但是与成像传输相当的机械指数或压力。 例如，提供约1.9或更低的机械指数，使得避免血液或其他非造影剂的气蚀。

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