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    Methods and compositions for delivering active agents with enhanced pharmacological properties
    3.
    发明授权
    Methods and compositions for delivering active agents with enhanced pharmacological properties 有权
    用于递送具有增强的药理学性质的活性剂的方法和组合物

    公开(公告)号：US08334257B2

    公开(公告)日：2012-12-18

    申请号：US12158190

    申请日：2006-12-20

    Applicant: Ashutosh Chilkoti

    Inventor： Ashutosh Chilkoti

    IPC: A61K38/22 ,  A61K38/39

    CPC classification number: C07K14/78 ,  A61K38/193 ,  A61K38/21 ,  A61K47/6435 ,  A61K49/085 ,  A61K49/14 ,  C07K2319/00

    Abstract: Provided herein are methods of enhancing in vivo efficacy of an active agent, comprising: administering to a subject an active agent that is coupled to a bioelastic polymer or elastin-like peptide, wherein the in vivo efficacy of the active agent is enhanced as compared to the same active agent when administered to the subject not coupled to (or not associated with) a bioelastic polymer or ELP.

    Abstract translation: 本文提供增强活性剂的体内功效的方法，其包括：向受试者施用与生物弹性聚合物或弹性蛋白样肽偶联的活性剂，其中活性剂的体内功效与 当向受试者施用不与生物弹性聚合物或ELP（或不结合）生物弹性聚合物或ELP时相同的活性剂。

    Direct drug delivery system based on thermally responsive biopolymers
    7.
    发明申请
    Direct drug delivery system based on thermally responsive biopolymers 审中-公开
    基于热响应生物聚合物的直接药物递送系统

    公开(公告)号：US20070009602A1

    公开(公告)日：2007-01-11

    申请号：US11472113

    申请日：2006-06-21

    Applicant: Lori Setton ,  Ashutosh Chilkoti ,  Virginia Kraus ,  Helawe Betre ,  Matthew Dreher

    Inventor： Lori Setton ,  Ashutosh Chilkoti ,  Virginia Kraus ,  Helawe Betre ,  Matthew Dreher

    IPC: A61K39/395 ,  A61K9/14 ,  A61M31/00

    CPC classification number: C07K14/78 ,  A61K9/0024 ,  A61K47/42 ,  A61K47/642 ,  A61K47/6435 ,  C07K14/7155

    Abstract: A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.

    Abstract translation: 将感兴趣的化合物的药物贮库递送至受试者的选定区域的方法。 该方法包括将组合物直接施用于所述感兴趣的区域，所述组合物包含待递送的目标化合物（例如抗炎剂或化学治疗剂）和经历的聚合物（例如弹性蛋白样肽或ELP） 逆温度相变，从而提供在所选择的区域的感兴趣的化合物的持续释放。 还描述了用于实施本发明的组合物。

    Fusion peptides isolatable by phase transition
    8.
    发明授权
    Fusion peptides isolatable by phase transition 有权
    融合肽可通过相变分离

    公开(公告)号：US06852834B2

    公开(公告)日：2005-02-08

    申请号：US09812382

    申请日：2001-03-20

    Applicant: Ashutosh Chilkoti

    Inventor： Ashutosh Chilkoti

    IPC: C07K14/36 ,  C07K14/78 ,  C12N9/02 ,  C12N15/62 ,  C12P21/04 ,  C07K1/10 ,  A23J1/10 ,  C12N9/82 ,  C12P21/08

    CPC classification number: C12N9/0036 ,  A01K2217/05 ,  C07K14/36 ,  C07K14/78 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/10 ,  C07K2319/20 ,  C07K2319/35 ,  C07K2319/40 ,  C07K2319/50 ,  C12N15/62

    Abstract: Genetically-encodable, environmentally-responsive fusion proteins comprising ELP peptides. Such fusion proteins exhibit unique physico-chemical and functional properties that can be modulated as a function of solution environment. The invention also provides methods for purifying the FPs, which take advantage of these unique properties, including high-throughput purification methods that produce high yields (e.g., milligram levels) of purified proteins, thereby yielding sufficient purified product for multiple assays and analyses. The high throughput purification technique is simpler and less expensive than current commercial high throughput purification methods, since it requires only one transfer of purification intermediates to a new multiwell plate.

    Abstract translation: 包含ELP肽的可遗传编码的环境反应性融合蛋白。 这种融合蛋白表现出独特的物理化学和功能特性，可以作为溶液环境的函数进行调节。 本发明还提供了纯化FP的方法，其利用这些独特性质，包括产生高产量（例如毫克级别）的纯化蛋白质的高通量纯化方法，由此产生足够的纯化产物用于多个测定和分析。 高通量纯化技术比现有的商业高通量纯化方法更简单和便宜，因为仅需要将一次净化中间体转移到新的多孔板上。

    Methods of using bioelastomers
    9.
    发明授权
    Methods of using bioelastomers 有权
    使用生物弹性体的方法

    公开(公告)号：US06582926B1

    公开(公告)日：2003-06-24

    申请号：US09695483

    申请日：2000-10-24

    Applicant: Ashutosh Chilkoti

    Inventor： Ashutosh Chilkoti

    IPC: G01N3353

    CPC classification number: B82Y30/00 ,  A61K41/00 ,  A61K47/58 ,  C07K16/1232

    Abstract: Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In general, the bioelastomer is conjugated to a binding compound, which is in turn used to bind a compound of interest. For targeted compound delivery, the bioelastomer is conjugated to the compound to be delivered.

    Abstract translation: 公开了生物弹性体用于结合化合物的方法，包括免疫测定方法，生物传感器和方法或再生生物传感器，以及用于将化合物递送到动物受试者内的特定位置的方法。 通常，生物弹性体与结合化合物缀合，结合化合物又用于结合感兴趣的化合物。 对于靶向化合物递送，生物弹性体与待递送的化合物缀合。

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