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公开(公告)号：US06282438B1
公开(公告)日：2001-08-28
申请号：US09203610
申请日：1998-12-02
IPC分类号： A61B600
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. After completion of the measurement or during the measurement, changes in concentration values of absorbers in the living body are determined from the living body transmitting light intensity levels of the plurality of wavelengths detected at the respective detection points and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point so as to image a function of the living body. In living body optical measurement system and method, the measuring time is shortened by estimating fluctuation attributable to the living body, the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time, and a local change in. hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by the two light detectors disposed at different two sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译： 以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平 波长和各个照射位置在生物体的表面上的不同位置处被测量。 在测量完成之后或在测量期间，生物体中的吸收体的浓度值的变化是根据在各个检测点处检测到的多个波长的光强度水平来发射的，并且将测量点设定在垂直方向 延伸穿过入射点和每个检测点之间的中间点，以便对活体的功能进行成像。 在生物体光学测量系统和方法中，通过估计归因于生物体的波动来缩短测量时间，通过一次显示估计信号和测量信号可以容易地确定测量信号的变化是否存在， 并且可以通过检测设置在被摄体上不同的两个位置（等于光入射点的位置）的两个光检测器检测通过生物体的内部的光线，并且仅分离本地 根据两个检测信号之间的对数差异，从生物体的血液动力学运动的总体变化中改变血流动力学运动。
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公开(公告)号：US07715904B2
公开(公告)日：2010-05-11
申请号：US11037339
申请日：2005-01-19
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译： 在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置 在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。 光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在 信号一次。
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公开(公告)号：US07142906B2
公开(公告)日：2006-11-28
申请号：US10689760
申请日：2003-10-22
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/055 , A61B5/14546 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B6/03 , A61B2562/0233 , A61B2562/0242 , A61B2562/046 , G01N21/35 , G01N21/4795
摘要： A control device and measurement system for a living body applies lights of at least one wavelength in a visible-infrared region to a plurality of incident positions on a surface of the living body, and a light detector detects lights transmitted through the living body at a plurality of detection positions on the surface of the living body. An operation unit determines a type of output signal, based on an intensity of the transmitted light and pre-stored reference data, and outputs a signal indicative thereof as the type of output signal. An external equipment executes a functional operation according to the type of output signal from the operation unit. The incident positions and the detection positions are alternately disposed in square lattice form and middle points between the incident positions and detection positions adjacent to one another are defined as measurement positions.
摘要翻译： 用于生物体的控制装置和测量系统将可见红外区域中的至少一个波长的光应用到生物体的表面上的多个入射位置，并且光检测器检测在生物体的一个 生物体表面上的多个检测位置。 操作单元基于发射光的强度和预先存储的参考数据来确定输出信号的类型，并输出表示其作为输出信号的类型的信号。 外部设备根据来自操作单元的输出信号的类型执行功能操作。 入射位置和检测位置交替地以方格格子形式设置，并且入射位置和彼此相邻的检测位置之间的中点被定义为测量位置。
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公开(公告)号：US20050148857A1
公开(公告)日：2005-07-07
申请号：US11037282
申请日：2005-01-19
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
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公开(公告)号：US20050131303A1
公开(公告)日：2005-06-16
申请号：US11037339
申请日：2005-01-19
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译： 在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置 在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。 光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在 信号一次。
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公开(公告)号：US06240309B1
公开(公告)日：2001-05-29
申请号：US08875081
申请日：1997-09-29
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B505
CPC分类号： A61B5/0059 , A61B5/055 , A61B5/14546 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B6/03 , A61B2562/0233 , A61B2562/0242 , A61B2562/046 , G01N21/35 , G01N21/4795
摘要： Described herein is an optical measurement instrument for a living body, comprising light incident means for simultaneously applying incident light of a wavelength in a visible-infrared region to a plurality of incident positions on the surface of a subject, light detection means for simultaneously detecting lights obtained by allowing the incident light to pass through the subject, at a plurality of detection positions on the surface of the subject, and imaging means for imaging information on the inside of the subject using detected signals outputted from the light detection means. The light incident means includes light modulation means for intensity-modulating the incident light applied to the plurality of incident positions with modulation frequencies respectively different every the respective incident positions. The light detection means includes selection and detection means for selecting and detecting transmitted light components of modulation frequencies respectively different every respective detection positions from the transmitted lights relative to the plurality of detection positions.
摘要翻译： 这里描述了一种用于生物体的光学测量仪器，包括用于将可见红外区域中的波长的入射光同时施加到被摄体表面上的多个入射位置的光入射装置，用于同时检测光的光检测装置 通过允许入射光通过被摄体，在被检体的表面上的多个检测位置而获得的成像装置，以及用于使用从光检测装置输出的检测信号对信息进行成像的成像装置。 光入射装置包括光调制装置，用于对施加到多个入射位置的入射光进行强度调制，调制频率各自在各个入射位置分别不同。 光检测装置包括选择和检测装置，用于从相对于多个检测位置的透射光中选择和检测分别与每个检测位置不同的调制频率的透射光分量。
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公开(公告)号：US06128517A
公开(公告)日：2000-10-03
申请号：US149155
申请日：1998-09-08
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B2562/0219 , A61B2562/0233 , A61B2562/046 , A61B5/055 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. After completion of the measurement or during the measurement, changes in concentration values of absorbers in the living body are determined from the living body transmitting light intensity levels of the plurality of wavelengths detected at the respective detection points and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point so as to image a function of the living body. In living body optical measurement system and method, the measuring time is shortened by estimating fluctuation attributable to the living body, the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time, and a local change in hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by means of two means for light detection disposed at different two sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译： 以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平 波长和各个照射位置在生物体的表面上的不同位置处被测量。 在测量完成之后或在测量期间，生物体中的吸收体的浓度值的变化是根据在各个检测点处检测到的多个波长的光强度水平来发射的，并且将测量点设定在垂直方向 延伸穿过入射点和每个检测点之间的中间点，以便对活体的功能进行成像。 在生物体光学测量系统和方法中，通过估计归因于生物体的波动来缩短测量时间，通过一次显示估计信号和测量信号可以容易地确定测量信号的变化是否存在， 并且可以通过检测设置在对象上不同的两个位置（等于光入射点）的光检测装置和仅分离的方式，通过检测透过活体内部的光线来测量血液动力学运动的局部变化 根据两个检测信号之间的对数差异，血液动力学运动的局部变化从生物体的血液动力学运动的整体变化。
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公开(公告)号：US5678556A
公开(公告)日：1997-10-21
申请号：US502844
申请日：1995-07-14
申请人： Atsushi Maki , Adi Bonen , Yoshitoshi Ito , Yuichi Yamashita , Yukiko Hirabayashi , Hideaki Koizumi , Fumio Kawaguchi , Hideji Fujii
发明人： Atsushi Maki , Adi Bonen , Yoshitoshi Ito , Yuichi Yamashita , Yukiko Hirabayashi , Hideaki Koizumi , Fumio Kawaguchi , Hideji Fujii
CPC分类号： G01N21/4795 , G01N2021/4797
摘要： An imaging method for spatial distributions of concentrations of absorbers distributed in an object including a radiation step of applying pulsating or continuous light radiated from predetermined incident positions with predetermined wavelengths to the object in the form of a scattering medium containing the absorbers, and a detection step of detecting intensities of light passing through the object at predetermined detection positions. The imaging method also includes a step of finding a plurality photon paths for a plurality of pairs of the incident and detected positions of a model with similar dimensions to the object but without absorbers starting at the incident positions and ending at the detected positions, a step of finding averaged photon-path lengths of the photon paths starting at the incident positions and ending at the detection positions in the model by simulation, a step of finding spatial distributions of absorber concentrations from the averaged photon-path lengths, radiated intensities of the radiated light applied to the object, detected intensities of light detected at the detection positions and optical constants of the absorbers for the radiated light applied to the object, and a step of displaying the spatial distributions of the absorber concentrations.
摘要翻译： 一种用于分散在物体中的吸收体的浓度的空间分布的成像方法，包括：将包含预定波长的预定入射位置的脉冲或连续光以包含吸收体的散射介质的形式施加到物体的辐射步骤;以及检测步骤 检测在预定检测位置通过物体的光的强度。 该成像方法还包括以下步骤：为具有与物体相似尺寸的模型的多个成对的入射和检测位置找到多个光子路径，但没有从入射位置开始并在检测位置结束的吸收体的步骤;步骤 通过模拟发现在入射位置开始并结束于模型中的检测位置的光子路径的平均光子路径长度，从平均光子路径长度，辐射强度的辐射强度中找到吸收剂浓度的空间分布的步骤 施加到物体的光，检测到的检测到的光的检测强度和被施加到物体的辐射光的吸收体的光学常数，以及显示吸收体浓度的空间分布的步骤。
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公开(公告)号：US07774047B2
公开(公告)日：2010-08-10
申请号：US11371916
申请日：2006-03-10
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B6/00
CPC分类号： A61B5/14546 , A61B5/14553 , A61B2562/0233 , A61B2562/0242 , A61B2562/046 , G01N21/35 , G01N21/4795
摘要： An optical measurement instrument for a living body to measure dynamic change of blood of a brain includes light incident units for irradiating light on a head of a subject, a light detector for detecting a light irradiated from the light incident units and reflected within the subject, a signal processing unit for calculating a spacious distribution of signals from the subject to be measured from a signal detected by the light detector, and a display for displaying the spacious distribution of signals from the subject to be measured. Measurement points are arranged about a middle of the light incident units and the light detector, and the light incident units and the light detector are arranged such that the measurement points are arranged to form a lattice whose circumference is square.
摘要翻译： 用于测量大脑血液动态变化的生物体的光学测量仪器包括用于照射被检体头部的光入射单元，用于检测从光入射单元照射并在被检体内反射的光的光检测器， 信号处理单元，用于根据由光检测器检测到的信号计算来自待测对象的信号的宽敞分布;以及显示器，用于显示来自待测对象的信号的宽敞分布。 测量点围绕光入射单元和光检测器的中间布置，并且光入射单元和光检测器被布置成使得测量点被布置成形成圆周为正方形的格子。
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公开(公告)号：US07440794B2
公开(公告)日：2008-10-21
申请号：US11037282
申请日：2005-01-19
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译： 在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置 在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。 光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在 信号一次。
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