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公开(公告)号：US20050171440A1
公开(公告)日：2005-08-04
申请号：US11037338
申请日：2005-01-19
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
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公开(公告)号：US06640133B2
公开(公告)日：2003-10-28
申请号：US09849409
申请日：2001-05-07
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B505
CPC分类号： A61B5/0059 , A61B5/055 , A61B5/14546 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B6/03 , A61B2562/0233 , A61B2562/0242 , A61B2562/046 , G01N21/35 , G01N21/4795
摘要： A control device for a living body including an input device having a launcher for launching light into the living body from at least one light incident position on a surface of the living body, a collector for collecting light obtained by causing the light incident from the light incident position to pass through the living body, at at least one light detection position on the surface of the living body, a detector for detecting an intensity of the transmitted light collected by the collector, an operator for determining a type of output signal, based on the intensity of the transmitted light, which has been detected by the detector and pre-stored reference data and for outputting a signal indicative thereof. External equipment is provided for using the signal outputted as an input signal and for executing a functional operation according to a type of the input signal.
摘要翻译： 一种生物体的控制装置，具有：输入装置，具有从生物体的表面上的至少一个光入射位置向所述生物体射出光的发射器，收集从所述光入射的光所得到的光的收集体 在生物体的表面上的至少一个光检测位置通过活体的入射位置，用于检测由收集器收集的透射光的强度的检测器，用于确定输出信号的类型的操作者 关于由检测器检测到的透射光的强度，以及预先存储的参考数据，并输出指示其的信号。 提供外部设备，用于使用作为输入信号输出的信号，并根据输入信号的类型执行功能操作。
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公开(公告)号：US06282438B1
公开(公告)日：2001-08-28
申请号：US09203610
申请日：1998-12-02
IPC分类号： A61B600
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. After completion of the measurement or during the measurement, changes in concentration values of absorbers in the living body are determined from the living body transmitting light intensity levels of the plurality of wavelengths detected at the respective detection points and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point so as to image a function of the living body. In living body optical measurement system and method, the measuring time is shortened by estimating fluctuation attributable to the living body, the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time, and a local change in. hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by the two light detectors disposed at different two sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译： 以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平 波长和各个照射位置在生物体的表面上的不同位置处被测量。 在测量完成之后或在测量期间，生物体中的吸收体的浓度值的变化是根据在各个检测点处检测到的多个波长的光强度水平来发射的，并且将测量点设定在垂直方向 延伸穿过入射点和每个检测点之间的中间点，以便对活体的功能进行成像。 在生物体光学测量系统和方法中，通过估计归因于生物体的波动来缩短测量时间，通过一次显示估计信号和测量信号可以容易地确定测量信号的变化是否存在， 并且可以通过检测设置在被摄体上不同的两个位置（等于光入射点的位置）的两个光检测器检测通过生物体的内部的光线，并且仅分离本地 根据两个检测信号之间的对数差异，从生物体的血液动力学运动的总体变化中改变血流动力学运动。
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公开(公告)号：US07774047B2
公开(公告)日：2010-08-10
申请号：US11371916
申请日：2006-03-10
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B6/00
CPC分类号： A61B5/14546 , A61B5/14553 , A61B2562/0233 , A61B2562/0242 , A61B2562/046 , G01N21/35 , G01N21/4795
摘要： An optical measurement instrument for a living body to measure dynamic change of blood of a brain includes light incident units for irradiating light on a head of a subject, a light detector for detecting a light irradiated from the light incident units and reflected within the subject, a signal processing unit for calculating a spacious distribution of signals from the subject to be measured from a signal detected by the light detector, and a display for displaying the spacious distribution of signals from the subject to be measured. Measurement points are arranged about a middle of the light incident units and the light detector, and the light incident units and the light detector are arranged such that the measurement points are arranged to form a lattice whose circumference is square.
摘要翻译： 用于测量大脑血液动态变化的生物体的光学测量仪器包括用于照射被检体头部的光入射单元，用于检测从光入射单元照射并在被检体内反射的光的光检测器， 信号处理单元，用于根据由光检测器检测到的信号计算来自待测对象的信号的宽敞分布;以及显示器，用于显示来自待测对象的信号的宽敞分布。 测量点围绕光入射单元和光检测器的中间布置，并且光入射单元和光检测器被布置成使得测量点被布置成形成圆周为正方形的格子。
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公开(公告)号：US07440794B2
公开(公告)日：2008-10-21
申请号：US11037282
申请日：2005-01-19
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译： 在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置 在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。 光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在 信号一次。
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公开(公告)号：US06901284B1
公开(公告)日：2005-05-31
申请号：US09913323
申请日：2000-02-18
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/7445 , A61B2562/0233 , A61B2562/046
摘要： An optical measuring apparatus for optically measuring a sample includes a plurality of parts for applying light beams to the sample, a plurality of detecting parts for detecting light beams from the light applying parts which come through the sample, a memory part which receives signals from the detecting parts, converts them into digital signals and stores the digital signals as measuring positions between the light applying part and the light detecting part. Further, there is provided a first display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts on the sample, and a second display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts which are shown on the first display part.
摘要翻译： 用于光学测量样品的光学测量装置包括用于向样品施加光束的多个部件，用于检测来自样品的光施加部分的光束的多个检测部分， 检测部件将它们转换为数字信号，并将数字信号存储在光施加部分和光检测部分之间的测量位置。 此外，提供了示出样品上的位置与样品上检测部位的位置对应的测量位置之间的关系的第一显示部分和示出样品和测量位置之间的关系的第二显示部分 对应于在第一显示部分上示出的检测部件的位置。
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7.发明授权Optical measurement equipment and recording medium and optical measurement method 有权光学测量设备及记录介质及光学测量方法公开(公告)号：US06542763B1
公开(公告)日：2003-04-01
申请号：US09697327
申请日：2000-10-27
IPC分类号： A61B500
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B2562/02 , A61B2562/0233 , A61B2562/046
摘要： In a system for performing imaging measurement of a test object by mounting many optical fibers to the test object, incident positions of the test object on which to illuminate light, detection positions of the test object from which to detect light and measurement positions which are determined from a positional relationship between the incident positions and the detection positions are displayed as graphic elements on a display unit. A state of detection signal level or a change in the state is displayed as a change in color or in pattern of the graphic element. Further, incident optical fibers for illuminating light to the test object and detection optical fibers for detecting light from the test object are mounted to the test object, and light emitting elements are mounted to probes to be mounted to the test object and interlocked with the change of the graphic elements.
摘要翻译： 在用于通过将许多光纤安装到测试对象上来进行测试对象的成像测量的系统中，用于照亮光的测试对象的入射位置，检测光的测试对象的检测位置和确定的测量位置 根据入射位置与检测位置之间的位置关系在显示单元上显示为图形元素。 检测信号电平状态或状态变化被显示为图形元素的颜色或图案的变化。 此外，将用于向测试对象照射光的入射光纤和用于检测来自测试对象的光的检测光纤安装在测试对象上，并且将发光元件安装到要安装到测试对象上的探针并与变化互锁 的图形元素。
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公开(公告)号：US08050744B2
公开(公告)日：2011-11-01
申请号：US11037338
申请日：2005-01-19
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译： 在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置 在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。 光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在 信号一次。
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公开(公告)号：US20060184047A1
公开(公告)日：2006-08-17
申请号：US11371919
申请日：2006-03-10
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B6/03
摘要： An input instrument for a living body, using an optical measurement system for the living body, includes first and second light incident units arranged on a head of a living body, and first and second light detectors which are paired with the first and the second light incident units respectively, and which are provided to collect light which passes through the living body based on the light irradiated onto the head of the living body by the light incident means. Measurement signals are obtained by measuring a plurality of regions of the living body by the first and the second light incident units, the first and the second light detectors, and characteristic parameters of the signals of an arbitrary time interval of the measured signals are calculated.
摘要翻译： 使用生物体的光学测量系统的生物体的输入仪器具有设置在生物体的头部的第一和第二光入射单元，以及与第一和第二光线配对的第一和第二光检测器 入射单元，其被设置成基于通过光入射装置照射到生物体的头部上的光来收集穿过生物体的光。 通过第一和第二光入射单元，第一和第二光检测器测量生物体的多个区域以及测量信号的任意时间间隔的信号的特性参数来计算测量信号。
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公开(公告)号：US5803909A
公开(公告)日：1998-09-08
申请号：US539871
申请日：1995-10-06
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B2562/0219 , A61B2562/0233 , A61B2562/046 , A61B5/055 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface Changes in concentration values of absorbers are determined from the living body transmitting light intensity levels and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point to image a function of the living body. The measuring time is shortened by estimating fluctuation attributable to the living body, and a local change in hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by light detection at two different sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译： 以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平 波长和各个照射位置在表面上的不同位置被测量吸收体的浓度值的变化由生物体透射光强度水平确定，并且测量点设置在延伸穿过入射点和每个之间的中间点的垂直 检测点成像生物体的功能。 通过估计生物体的波动来缩短测量时间，并且可以通过在两个不同位置（等于光入射点的光检测）检测透射通过生物体内部的光线来测量血液动力学运动的局部变化 ），并且根据两个检测信号之间的对数差异仅分离血液动力学运动的局部变化与生物体中的血液动力学运动的总体变化。
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