中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

25 records (took 0.031 seconds)

    MIXED LINEAGE KINASE INHIBITORS FOR HIV/AIDS THERAPIES
    11.
    发明申请
    MIXED LINEAGE KINASE INHIBITORS FOR HIV/AIDS THERAPIES 审中-公开
    混合线性激酶抑制剂用于艾滋病毒/艾滋病治疗

    公开(公告)号：US20150297587A1

    公开(公告)日：2015-10-22

    申请号：US14648404

    申请日：2013-11-30

    Applicant: UNIVERSITY OF ROCHESTER ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

    Inventor： Harris A. Gelbard ,  Stephen Dewhurst ,  Howard E. Gendelman

    IPC: A61K31/496 ,  A61K9/48 ,  A61K45/06 ,  A61K31/4418 ,  A61K31/427

    CPC classification number: A61K31/496 ,  A61K9/4866 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/506 ,  A61K31/536 ,  A61K31/553 ,  A61K45/06 ,  A61K2300/00

    Abstract: Disclosed are methods for treating an individual infected with a retrovirus that comprise administering to the individual effective amounts of a mixed lineage kinase inhibitor and antiretroviral drug. In further aspects, disclosed are methods for treating an individual infected with a retrovirus that comprises administering an antiretroviral drug formulated into a crystalline nanoparticle comprising a surfactant, and a MLK inhibitor. Still further disclosed are methods for treating an individual infected with a retrovirus that comprises administering a composition comprising both an antiretroviral and MLK inhibitor formulated into a crystalline nanoparticle, which comprises a surfactant. Still further disclosed are compositions that comprise an antiretroviral drug, a MLK inhibitor, and a surfactant, wherein the composition is a crystalline nanoparticle. Compostions comprising MLK inhibitors with other drugs in nanoparticulate form, and methods of there use, are also disclosed.

    Abstract translation: 公开了用于治疗感染了逆转录病毒的个体的方法，其包括向个体有效量施用混合谱系激酶抑制剂和抗逆转录病毒药物。 在另外的方面，公开了用于治疗感染了逆转录病毒的个体的方法，其包括施用配制成包含表面活性剂的结晶纳米颗粒和MLK抑制剂的抗逆转录病毒药物。 还进一步公开的是用于治疗感染了逆转录病毒的个体的方法，其包括施用包含配制成包含表面活性剂的结晶纳米颗粒的抗逆转录病毒和MLK抑制剂的组合物。 还进一步公开的是包含抗逆转录病毒药物，MLK抑制剂和表面活性剂的组合物，其中所述组合物是结晶纳米颗粒。 还公开了包含MLK抑制剂与纳米颗粒形式的其它药物的组合物及其使用方法。

    TUNABLE MULTIMODAL NANOPARTICLES AND METHODS OF USE THEREOF
    17.
    发明申请
    TUNABLE MULTIMODAL NANOPARTICLES AND METHODS OF USE THEREOF 审中-公开
    可多重多元纳米粒子及其使用方法

    公开(公告)号：US20150079007A1

    公开(公告)日：2015-03-19

    申请号：US14394025

    申请日：2013-04-22

    Applicant: Board of Regents of the University of Nebraska

    Inventor： Xin-Ming Liu ,  Alexander V. Kabanov ,  Howard E. Gendelman

    IPC: A61K9/50 ,  A61K49/00 ,  A61K49/18

    CPC classification number: A61K9/5031 ,  A61K49/0002 ,  A61K49/1857 ,  A61K49/186

    Abstract: Tunable nanoparticles and methods of use thereof are provided. In accordance with the instant invention, tunable nanoparticles comprising a metal nanoparticle core (e.g., a paramagnetic particle (e.g., USPIO) or a quantum dot) and a polymer linked to a metal binding moiety are provided. The polymer of the nanoparticle is bound to the metal nanoparticle core by the metal binding moiety and coats the metal nanoparticle core. In a particular embodiment, the metal binding moiety comprises bisphosphonate, pyrophosphate, or a derivative thereof. In a particular embodiment, the polymer is a hydrophilic polymer, an amphiphilic block copolymer or an ionic block copolymer.

    Abstract translation: 提供可调谐纳米颗粒及其使用方法。 根据本发明，提供了包含金属纳米颗粒核心（例如，顺磁性颗粒（例如USPIO）或量子点））和连接到金属结合部分的聚合物的可调谐纳米颗粒。 纳米颗粒的聚合物通过金属结合部分与金属纳米颗粒核心结合并涂覆金属纳米颗粒核心。 在一个具体实施方案中，金属结合部分包括双膦酸盐，焦磷酸盐或其衍生物。 在一个具体实施方案中，聚合物是亲水性聚合物，两亲嵌段共聚物或离子嵌段共聚物。

Patent Agency Ranking