公开(公告)号：US09850225B2

公开(公告)日：2017-12-26

申请号：US14681772

申请日：2015-04-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Louis S. Chupak ,  Min Ding ,  Scott W. Martin ,  Xiaofan Zheng ,  Piyasena Hewawasam ,  Timothy P. Connolly ,  Ningning Xu ,  Kap-Sun Yeung ,  Juliang Zhu ,  David R. Langley ,  Paul Michael Scola

IPC: C07D319/18 ,  A61K31/357 ,  C07D405/12 ,  A61K31/453 ,  C07D405/14 ,  A61K31/4545 ,  C07D217/16 ,  A61K31/472 ,  C07D413/12 ,  A61K31/5377 ,  C07D417/12 ,  A61K31/541 ,  A61K31/496 ,  A61K45/06 ,  C07C255/54 ,  C07D215/14 ,  C07D215/18 ,  C07D231/56 ,  C07D405/04 ,  C07D239/26 ,  C07D261/08 ,  C07D271/06 ,  C07D207/26 ,  C07D207/335 ,  C07D213/30 ,  C07C271/28 ,  C07C317/22 ,  C07C233/36 ,  C07C235/42 ,  C07C255/13 ,  A61K31/165 ,  A61K31/277 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/47 ,  A61K31/505

CPC classification number: C07D319/18 ,  A61K31/165 ,  A61K31/277 ,  A61K31/357 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C233/36 ,  C07C235/42 ,  C07C255/13 ,  C07C255/54 ,  C07C271/28 ,  C07C317/22 ,  C07D207/26 ,  C07D207/335 ,  C07D213/30 ,  C07D215/14 ,  C07D215/18 ,  C07D217/16 ,  C07D231/56 ,  C07D239/26 ,  C07D261/08 ,  C07D271/06 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/463 ,  A61K2300/00

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20150291549A1

公开(公告)日：2015-10-15

申请号：US14681772

申请日：2015-04-08

Applicant: Bristol-Myers Squibb Company

Inventor： Louis S. Chupak ,  Min Ding ,  Scott W. Martin ,  Xiaofan Zheng ,  Piyasena Hewawasam ,  Timothy P. Connolly ,  Ningning Xu ,  Kap-Sun Yeung ,  Juliang Zhu ,  David R. Langley ,  Daniel J. Tenney ,  Paul Michael Scola

IPC: C07D319/18 ,  C07D405/12 ,  A61K31/453 ,  C07D405/14 ,  A61K31/4545 ,  A61K45/06 ,  A61K31/472 ,  C07D413/12 ,  A61K31/5377 ,  C07D417/12 ,  A61K31/541 ,  A61K31/496 ,  A61K31/357 ,  C07D217/16

CPC classification number: C07D319/18 ,  A61K31/165 ,  A61K31/277 ,  A61K31/357 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C233/36 ,  C07C235/42 ,  C07C255/13 ,  C07C255/54 ,  C07C271/28 ,  C07C317/22 ,  C07D207/26 ,  C07D207/335 ,  C07D213/30 ,  C07D215/14 ,  C07D215/18 ,  C07D217/16 ,  C07D231/56 ,  C07D239/26 ,  C07D261/08 ,  C07D271/06 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/463 ,  A61K2300/00

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Abstract translation: 本公开一般涉及可用作免疫调节剂的化合物。 本文提供的化合物，包含这些化合物的组合物及其使用方法。 本公开还涉及包含至少一种根据本公开的化合物的药物组合物，其可用于治疗各种疾病，包括癌症和感染性疾病。

公开(公告)号：US20130171098A1

公开(公告)日：2013-07-04

申请号：US13778507

申请日：2013-02-27

Applicant: Bristol-Myers Squibb Company

Inventor： John A. Bender ,  Min Ding ,  Robert G. Gentles ,  Piyasena Hewawasam

IPC: A61K31/55 ,  A61K45/06

CPC classification number: C07D487/08 ,  A61K31/55 ,  A61K45/06 ,  C07D471/08 ,  C07D487/04 ,  C07D519/00

Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

公开(公告)号：US11713316B2

公开(公告)日：2023-08-01

申请号：US17164009

申请日：2021-02-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Upender Velaparthi ,  Louis S. Chupak ,  Chetan Padmakar Darne ,  Min Ding ,  Robert G. Gentles ,  Yazhong Huang ,  Manjunatha Narayana Rao Kamble ,  Scott W. Martin ,  Raju Mannoori ,  Ivar M. McDonald ,  Richard E. Olson ,  Hasibur Rahaman ,  Prasada Rao Jalagam ,  Saumya Roy ,  Gopikishan Tonukunuru ,  Sivasudar Velaiah ,  Jayakumar Sankara Warrier ,  Xiaofan Zheng ,  John S. Tokarski ,  Bireshwar Dasgupta ,  Kotha Rathnakar Reddy ,  Thiruvenkadam Raja

IPC: C07D403/04 ,  C07D471/04 ,  C07D487/04 ,  A61K31/196

CPC classification number: C07D471/04

Abstract: Disclosed are compounds of Formula (I):




or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20220324859A1

公开(公告)日：2022-10-13

申请号：US17164009

申请日：2021-02-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Upender Velaparthi ,  Louis S. Chupak ,  Chetan Padmakar Darne ,  Min Ding ,  Robert G. Gentles ,  Yazhong Huang ,  Manjunatha Narayana Rao Kamble ,  Scott W. Martin ,  Raju Mannoori ,  Ivar M. McDonald ,  Richard E. Olson ,  Hasibur Rahaman ,  Prasada Rao Jalagam ,  Saumya Roy ,  Gopikishan Tonukunuru ,  Sivasudar Velaiah ,  Jayakumar Sankara Warrier ,  Xiaofan Zheng ,  John S. Tokarski ,  Bireshwar Dasgupta ,  Kotha Rathnakar Reddy ,  Thiruvenkadam Raja

IPC: C07D471/04

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20140186299A1

公开(公告)日：2014-07-03

申请号：US14197343

申请日：2014-03-05

Applicant: Bristol-Myers Squibb Company

Inventor： John A. Bender ,  Min Ding ,  Robert G. Gentles ,  Piyasena Hewawasam

IPC: C07D487/08 ,  A61K31/55 ,  A61K45/06

CPC classification number: C07D487/08 ,  A61K31/55 ,  A61K45/06 ,  C07D471/08 ,  C07D487/04 ,  C07D519/00

Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

公开(公告)号：US20140045816A1

公开(公告)日：2014-02-13

申请号：US14048856

申请日：2013-10-08

Applicant: Bristol-Myers Squibb Company

Inventor： John A. Bender ,  Min Ding ,  Robert G. Gentles ,  Piyasena Hewawasam

IPC: C07D487/04 ,  C07D471/08

CPC classification number: C07D487/08 ,  A61K31/55 ,  A61K45/06 ,  C07D471/08 ,  C07D487/04 ,  C07D519/00

Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Abstract translation: 本发明包括式I化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。