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1.发明申请MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS 有权PD-1 / PD-L1和CD80（B7-1）/ PD-L1蛋白/蛋白质相互作用的MACROCYCLIC抑制剂公开(公告)号：US20140294898A1
公开(公告)日：2014-10-02
申请号：US14201977
申请日：2014-03-10
发明人： Michael Matthew Miller , Claudio Mapelli , Martin Patrick Allen , Michael S. Bowsher , Kenneth M. Boy , Eric P. Gillis , David R. Langley , Eric Mull , Maude A. Poirier , Nishith Sanghvi , Li-Qiang Sun , Daniel J. Tenney , Kap-Sun Yeung , Juliang Zhu , Patrick C. Reid , Paul Michael Scola
CPC分类号： C07K7/56 , A61K38/00 , A61K38/10 , A61K39/39 , A61K45/06 , C07K7/08 , G01N33/574 , G01N2333/70532 , G01N2500/02 , G01N2800/26 , Y02A50/463
摘要： The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
摘要翻译： 本公开提供了抑制PD-1 / PD-L1和PD-L1 / CD80蛋白/蛋白相互作用的新型大环肽，因此可用于改善各种疾病，包括癌症和感染性疾病。
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公开(公告)号：US09850225B2
公开(公告)日：2017-12-26
申请号：US14681772
申请日：2015-04-08
发明人： Louis S. Chupak , Min Ding , Scott W. Martin , Xiaofan Zheng , Piyasena Hewawasam , Timothy P. Connolly , Ningning Xu , Kap-Sun Yeung , Juliang Zhu , David R. Langley , Paul Michael Scola
IPC分类号： C07D319/18 , A61K31/357 , C07D405/12 , A61K31/453 , C07D405/14 , A61K31/4545 , C07D217/16 , A61K31/472 , C07D413/12 , A61K31/5377 , C07D417/12 , A61K31/541 , A61K31/496 , A61K45/06 , C07C255/54 , C07D215/14 , C07D215/18 , C07D231/56 , C07D405/04 , C07D239/26 , C07D261/08 , C07D271/06 , C07D207/26 , C07D207/335 , C07D213/30 , C07C271/28 , C07C317/22 , C07C233/36 , C07C235/42 , C07C255/13 , A61K31/165 , A61K31/277 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/4433 , A61K31/47 , A61K31/505
CPC分类号： C07D319/18 , A61K31/165 , A61K31/277 , A61K31/357 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/4433 , A61K31/453 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C233/36 , C07C235/42 , C07C255/13 , C07C255/54 , C07C271/28 , C07C317/22 , C07D207/26 , C07D207/335 , C07D213/30 , C07D215/14 , C07D215/18 , C07D217/16 , C07D231/56 , C07D239/26 , C07D261/08 , C07D271/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
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公开(公告)号：US20150291549A1
公开(公告)日：2015-10-15
申请号：US14681772
申请日：2015-04-08
发明人： Louis S. Chupak , Min Ding , Scott W. Martin , Xiaofan Zheng , Piyasena Hewawasam , Timothy P. Connolly , Ningning Xu , Kap-Sun Yeung , Juliang Zhu , David R. Langley , Daniel J. Tenney , Paul Michael Scola
IPC分类号： C07D319/18 , C07D405/12 , A61K31/453 , C07D405/14 , A61K31/4545 , A61K45/06 , A61K31/472 , C07D413/12 , A61K31/5377 , C07D417/12 , A61K31/541 , A61K31/496 , A61K31/357 , C07D217/16
CPC分类号： C07D319/18 , A61K31/165 , A61K31/277 , A61K31/357 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/4433 , A61K31/453 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C233/36 , C07C235/42 , C07C255/13 , C07C255/54 , C07C271/28 , C07C317/22 , C07D207/26 , C07D207/335 , C07D213/30 , C07D215/14 , C07D215/18 , C07D217/16 , C07D231/56 , C07D239/26 , C07D261/08 , C07D271/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
摘要翻译： 本公开一般涉及可用作免疫调节剂的化合物。 本文提供的化合物，包含这些化合物的组合物及其使用方法。 本公开还涉及包含至少一种根据本公开的化合物的药物组合物，其可用于治疗各种疾病，包括癌症和感染性疾病。
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公开(公告)号：US10745382B2
公开(公告)日：2020-08-18
申请号：US15290167
申请日：2016-10-11
发明人： Kap-Sun Yeung , Timothy P. Connolly , David B. Frennesson , Katharine A. Grant-Young , Piyasena Hewawasam , David R. Langley , Zhaoxing Meng , Eric Mull , Kyle E. Parcella , Mark George Saulnier , Li-Qiang Sun , Alan Xiangdong Wang , Ningning Xu , Juliang Zhu , Paul Michael Scola
IPC分类号： C07D401/14 , C07D213/71 , C07D455/02 , A61K31/135 , A61K31/138 , A61K31/166 , A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C215/20 , C07C235/46 , C07D205/04 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D213/80 , C07D213/82 , C07D213/85 , C07D265/30 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/08 , C07D491/08
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
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公开(公告)号：US10590105B2
公开(公告)日：2020-03-17
申请号：US16315800
申请日：2017-07-05
发明人： Kap-Sun Yeung , Katharine A. Grant-Young , Juliang Zhu , Mark G. Saulnier , David B. Frennesson , Zhaoxing Meng , Paul Michael Scola
IPC分类号： C07D401/10 , C07D413/14 , C07D417/12 , C07D405/12 , C07D401/14 , C07D413/12 , C07D401/12 , A61K31/4439 , A61K31/4545 , A61K31/498 , A61K45/06 , C07D405/14 , C07D417/14
摘要： The present disclosure generally relates to compounds of formula (I), wherein R2 is a phenyl or pyridinyl moiety, useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
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6.发明授权公开(公告)号：US09850283B2
公开(公告)日：2017-12-26
申请号：US15009575
申请日：2016-01-28
发明人： Michael Matthew Miller , Claudio Mapelli , Martin Patrick Allen , Michael S. Bowsher , Kenneth M. Boy , Eric P. Gillis , David R. Langley , Eric Mull , Maude A. Poirier , Nishith Sanghvi , Li-Qiang Sun , Daniel J. Tenney , Kap-Sun Yeung , Juliang Zhu , Patrick C. Reid , Paul Michael Scola
IPC分类号： C07K7/56 , A61K38/12 , C07K7/08 , G01N33/68 , A61K38/10 , A61K39/39 , A61K45/06 , G01N33/574 , A61K38/00
CPC分类号： C07K7/56 , A61K38/00 , A61K38/10 , A61K39/39 , A61K45/06 , C07K7/08 , G01N33/574 , G01N2333/70532 , G01N2500/02 , G01N2800/26 , Y02A50/463
摘要： The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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7.发明授权公开(公告)号：US10538555B2
公开(公告)日：2020-01-21
申请号：US15510138
申请日：2014-09-11
发明人： Michael Matthew Miller , Claudio Mapelli , Martin Patrick Allen , Michael S. Bowsher , Eric P. Gillis , David R. Langley , Eric Mull , Maude A. Poirier , Nishith Sanghvi , Li-Qiang Sun , Daniel J. Tenney , Kap-Sun Yeung , Juliang Zhu , Kevin W. Gillman , Qian Zhao , Katharine A. Grant-Young , Paul Michael Scola , Lyndon A. M. Cornelius
摘要： The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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公开(公告)号：US20180057455A1
公开(公告)日：2018-03-01
申请号：US15689115
申请日：2017-08-29
发明人： KAP-SUN YEUNG , Katharine A. Grant-Young , Juliang Zhu , Mark G. Saulnier , David B. Frennesson , David R. Langley , Piyasena Hewawasam , Tao Wang , Zhongxing Zhang , Zhaoxing Meng , Li-Qiang Sun , Eric Mull , Paul Michael Scola
IPC分类号： C07D207/12 , C07D211/66 , C07D207/16 , C07D403/12 , C07D401/12 , C07D207/14 , C07D211/22 , C07D213/38 , C07D401/14 , C07C237/06 , C07D295/088 , C07D205/04 , C07D213/85 , C07C217/18 , C07D213/73 , C07D405/12 , C07C255/24 , C07D413/14 , C07D405/14 , C07D213/79 , C07D231/12 , C07D239/26 , C07D277/28 , C07D211/90
CPC分类号： C07D207/12 , C07C217/18 , C07C217/28 , C07C217/58 , C07C229/14 , C07C235/08 , C07C237/04 , C07C237/06 , C07C255/24 , C07C255/25 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/60 , C07D211/66 , C07D211/90 , C07D213/38 , C07D213/42 , C07D213/55 , C07D213/73 , C07D213/79 , C07D213/85 , C07D231/12 , C07D239/26 , C07D277/28 , C07D295/088 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
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9.发明申请公开(公告)号：US20170260237A1
公开(公告)日：2017-09-14
申请号：US15510138
申请日：2014-09-11
发明人： Michael Matthew Miller , Claudio Mapelli , Martin Patrick Allen , Michael S. Bowsher , Eric P. Gillis , David R. Langley , Eric Mull , Maude A. Poirier , Nishith Sanghvi , Li-Qiang Sun , Daniel J. Tenney , Kap-Sun Yeung , Juliang Zhu , Kevin W. Gillman , Qian Zhao , Katharine A. Grant-Young , Paul Michael Scola , Lyndon A.M. Cornelius
摘要： The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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10.发明授权Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions 有权PD-1 / PD-L1和CD80（B7-1）/ PD-L1蛋白/蛋白相互作用的大环抑制剂公开(公告)号：US09308236B2
公开(公告)日：2016-04-12
申请号：US14201977
申请日：2014-03-10
发明人： Michael Matthew Miller , Claudio Mapelli , Martin Patrick Allen , Michael S. Bowsher , Kenneth M. Boy , Eric P. Gillis , David R. Langley , Eric Mull , Maude A. Poirier , Nishith Sanghvi , Li-Qiang Sun , Daniel J. Tenney , Kap-Sun Yeung , Juliang Zhu , Patrick C. Reid , Paul Michael Scola
IPC分类号： C07K7/56 , A61K38/12 , C07K7/08 , G01N33/68 , A61K38/10 , A61K39/39 , A61K45/06 , G01N33/574 , A61K38/00
CPC分类号： C07K7/56 , A61K38/00 , A61K38/10 , A61K39/39 , A61K45/06 , C07K7/08 , G01N33/574 , G01N2333/70532 , G01N2500/02 , G01N2800/26 , Y02A50/463
摘要： The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
摘要翻译： 本公开提供了抑制PD-1 / PD-L1和PD-L1 / CD80蛋白/蛋白相互作用的新型大环肽，因此可用于改善各种疾病，包括癌症和感染性疾病。
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