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公开(公告)号：US20130230505A1
公开(公告)日：2013-09-05
申请号：US13700410
申请日：2011-05-26
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00
CPC分类号： C07K16/40 , A61K9/0019 , A61K38/00 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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12.发明申请公开(公告)号：US20130202576A1
公开(公告)日：2013-08-08
申请号：US13809757
申请日：2011-07-12
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C12N9/93 , A61K38/00 , A61K38/53 , C07K16/40 , C12N5/0602 , C12N9/96 , C12Y601/01 , C12Y601/01021 , G01N33/68
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US20130202574A1
公开(公告)日：2013-08-08
申请号：US13695229
申请日：2011-04-29
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry Dean Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry Dean Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
CPC分类号： C07K16/40 , A61K9/0019 , A61K9/19 , A61K38/53 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01009 , G01N33/5011 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/10
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US07714120B2
公开(公告)日：2010-05-11
申请号：US12428558
申请日：2009-04-23
CPC分类号： C07K16/245 , A61K2039/505 , C07K2317/565
摘要： The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof, generally exhibit high binding affinities (low kooff values), reduced deamidation compared to the native antibody, and can be used to treat various diseases such as rheumatoid arthritis, osteoarthritis, or neuroinflammation.
摘要翻译： 本发明包括与成熟的人IL-1β特异性结合的分离的抗体或其抗原结合部分。 与天然抗体相比，这些抗体或其抗原结合部分通常表现出高的结合亲和力（低kooff值），减少的脱酰胺化，并且可以用于治疗各种疾病如类风湿性关节炎，骨关节炎或神经炎症。
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公开(公告)号：US09127268B2
公开(公告)日：2015-09-08
申请号：US13514952
申请日：2010-12-10
申请人： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kristi Helen Piehl , Fei Hong , Kyle P. Chiang , Wei Zhang , Alina He
发明人： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kristi Helen Piehl , Fei Hong , Kyle P. Chiang , Wei Zhang , Alina He
IPC分类号： C12N9/00 , A61K38/53 , A61K39/395 , A61K45/06
CPC分类号： A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
摘要： Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
摘要翻译： 提供包含氨基-tRNA合成酶多肽的炎症和其它细胞应答调节组合物，包括其活性片段和/或变体。 还提供了使用这些组合物来治疗受益于炎症疾病或病症等炎症调节的病症的方法。
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16.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases 有权创新发现治疗，诊断和抗体组合物相关的精氨酰-tRNA合成酶的蛋白质片段公开(公告)号：US08961961B2
公开(公告)日：2015-02-24
申请号：US13696042
申请日：2011-05-02
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： A61K39/3955 , A61K9/19 , A61K38/00 , A61K38/53 , A61K2039/505 , A61K2121/00 , C07K16/40 , C07K2319/00 , C12N9/1085 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US20120064082A1
公开(公告)日：2012-03-15
申请号：US13162559
申请日：2011-06-16
申请人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
发明人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
IPC分类号： A61K39/395 , A61P7/00 , C07K16/18
CPC分类号： C07K16/40 , A61K38/53 , A61K39/39533 , C07K2317/20 , C07K2317/33 , A61K2300/00
摘要： Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.
摘要翻译： 提供造血调节组合物，其包含氨酰-tRNA合成酶多肽，包括其活性片段和/或变体，以及包含相关试剂如抗体和其它结合剂的组合物。 还提供了使用这些组合物治疗受益于造血细胞调节的病症的方法。
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公开(公告)号：US07541033B2
公开(公告)日：2009-06-02
申请号：US10542508
申请日：2004-01-21
IPC分类号： C07K16/00 , C07K16/24 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/245 , A61K2039/505 , C07K2317/565
摘要： The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof, generally exhibit high binding affinities (low kooff values), reduced deamidation compared to the native antibody, and can be used to treat various diseases such as rheumatoid arthritis, osteoarthritis, or neuroinflammation.
摘要翻译： 本发明包括与成熟的人IL-1β特异性结合的分离的抗体或其抗原结合部分。 与天然抗体相比，这些抗体或其抗原结合部分通常表现出高的结合亲和力（低kooff值），减少的脱酰胺化，并且可以用于治疗各种疾病如类风湿性关节炎，骨关节炎或神经炎症。
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公开(公告)号：US20130230507A1
公开(公告)日：2013-09-05
申请号：US13696049
申请日：2011-05-04
申请人： Leslie Ann Greene , Kyle P. Chiang , Alain Philippe Vasserot , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Alain Philippe Vasserot , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , G01N33/573 , G01N33/68 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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20.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED PROTEIN FRAGMENTS OF ARGINYL-TRNA SYNTHETASES 有权治疗，诊断和抗体组合物的创新发现ARGINYL-TRNA合成蛋白相关蛋白质片段公开(公告)号：US20130142774A1
公开(公告)日：2013-06-06
申请号：US13696042
申请日：2011-05-02
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00
CPC分类号： A61K39/3955 , A61K9/19 , A61K38/00 , A61K38/53 , A61K2039/505 , A61K2121/00 , C07K16/40 , C07K2319/00 , C12N9/1085 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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