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公开(公告)号:US09765058B2
公开(公告)日:2017-09-19
申请号:US14900599
申请日:2014-06-17
发明人: Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Gerhard Siemeister , Wilhelm Bone , Amaury Ernesto Fernandez-Montalvan , Jens Schröder , Simon Holton , Cornelia Preuβe , Ursula Mönning
IPC分类号: C07D401/14 , A61K45/06 , A61K31/506
CPC分类号: C07D401/14 , A61K31/506 , A61K45/06
摘要: Compounds of formula (I), and their use as pharmaceuticals.
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公开(公告)号:US09682974B2
公开(公告)日:2017-06-20
申请号:US15032957
申请日:2014-10-27
发明人: Anne Mengel , Anja Richter , Marion Hitchcock , Hans Briem , Gerhard Siemeister , Wilhelm Bone , Amaury Ernesto Fernandez-Montalvan , Jens Schröder , Simon Holton , Cornelia Preuβe , Ursula Mönning
IPC分类号: C07D403/14 , A61K31/506 , C07D417/14 , C07D401/14 , A61K31/4439 , A61K31/5377 , A61K45/06
CPC分类号: C07D417/14 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14
摘要: Compounds of formula (I), processes for their preparation and their use as pharmaceuticals.
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公开(公告)号:US09422268B2
公开(公告)日:2016-08-23
申请号:US14365895
申请日:2012-12-17
发明人: Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号: C07D401/14 , A61K31/506 , C07D405/14
摘要: Compounds of formula (I) and their use as pharmaceutical.
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公开(公告)号:US09265763B2
公开(公告)日:2016-02-23
申请号:US14350160
申请日:2012-10-04
发明人: Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号: C07D401/14 , A61K31/506 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/5377 , A61K31/5383 , A61K45/06
摘要: Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号:US20140315934A1
公开(公告)日:2014-10-23
申请号:US14365895
申请日:2012-12-17
发明人: Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernandez-Montalvan , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuße
IPC分类号: C07D401/14 , C07D405/14 , A61K31/506
CPC分类号: C07D401/14 , A61K31/506 , C07D405/14
摘要: Compounds of formula (I) and their use as pharmaceutical.
摘要翻译: 式(I)化合物及其作为药物的用途。
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公开(公告)号:US11529356B2
公开(公告)日:2022-12-20
申请号:US16999832
申请日:2020-08-21
发明人: Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Marcus Koppitz , Knut Eis , Franz Von Nussbaum , Benjamin Bader , Antje Margret Wengner , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Joanna Grudzinska-Goebel , Dieter Moosmayer , Uwe Eberspächer , Hans Schick
IPC分类号: A61K31/4375 , A61K31/5377 , A61K31/4155 , C07D471/04 , C07D519/00 , C07D413/14 , A61P35/00 , A61P35/02 , A61K31/541 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D491/22 , C07F9/6561
摘要: The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号:US10266548B2
公开(公告)日:2019-04-23
申请号:US15438254
申请日:2017-02-21
发明人: Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号: C07D401/14 , C07D498/04 , C07D405/14 , C07D413/14 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D403/04
摘要: Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号:US20160287604A1
公开(公告)日:2016-10-06
申请号:US15159548
申请日:2016-05-19
发明人: Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Franz Von Nussbaum , Benjamin Bader , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Dieter Moosmayer , Uwe Eberspächer , Hans Schick , Knut Eis , Marcus Koppitz , Antje Margret Wengner , Joanna Grudzinska-Goebel
IPC分类号: A61K31/5377 , C07D471/04 , C07F9/6561 , A61K31/55 , A61K31/541 , C07D519/00 , A61K31/5386 , C07D491/22 , A61K45/06 , A61K31/675
CPC分类号: A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要: The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译: 制备所述化合物的方法,可用于制备所述化合物的中间体化合物,包含所述化合物的药物组合物和组合,以及所述化合物用于制备用于治疗或预防疾病,特别是过度增殖的药物组合物的用途 疾病作为唯一的代理或与其他活性成分组合。
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公开(公告)号:US10894784B2
公开(公告)日:2021-01-19
申请号:US16063370
申请日:2016-12-15
发明人: Volker Schulze , Tobias Heinrich , Florian Prinz , Julien Lefranc , Jens Schröder , Anne Mengel , Wilhelm Bone , Joszef Bálint , Antje Margret Wengner , Knut Eis , Horst Irlbacher , Marcus Koppitz , Ulf Bömer , Benjamin Bader , Hans Briem , Philip Lienau , Clara Christ , Detlef Stöckigt , Roman Hillig
IPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08 , A61P35/00
摘要: The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号:US10604532B2
公开(公告)日:2020-03-31
申请号:US16360811
申请日:2019-03-21
发明人: Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号: C07D401/14 , C07D498/04 , C07D405/14 , C07D413/14 , A01H6/36 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D403/04
摘要: Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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