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公开(公告)号：US20130337575A1
公开(公告)日：2013-12-19
申请号：US13912602
申请日：2013-06-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel N. Fox , Susan Hunter , Nathan Michael Gaskill-Fox , Kevin P. Raley , Richard A. Miles
IPC: G01N21/64
CPC classification number: G01N21/64 , G01N15/1012 , G01N15/1427 , G01N15/1459 , G01N2015/1006 , G01N2015/1406 , G01N2015/149
Abstract: Disclosed is an automated method and apparatus for automatically setting a drop delay period by detecting calibration particles in a waste stream. The drop delay is incremented over a series of drop delays and the number of calibration particles in the waste stream is detected for each drop delay. The drop delay is selected which has the least number of calibration particles in the waste stream.
Abstract translation: 公开了一种自动化方法和装置，用于通过检测废物流中的校准颗粒来自动设定落下延迟期。 丢弃延迟在一系列延迟延迟中增加，并且针对每个丢弃延迟检测废物流中的校准粒子的数量。 选择在废物流中具有最少数量的校准颗粒的液滴延迟。
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公开(公告)号：US20180128266A1
公开(公告)日：2018-05-10
申请号：US15345462
申请日：2016-11-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Nathan Michael Gaskill-Fox , Daniel Nelson Fox
CPC classification number: F04B49/20 , F04B11/00 , F04B23/06 , F04B43/0072 , F04B43/1261 , F04B49/065 , F04B49/08 , F04B51/00 , F04B2205/04 , F04B2205/503
Abstract: Methods and systems for pumping fluid through tubing are provided. Methods include orbiting one or more first rollers at multiple angular speeds around the periphery of a substantially circular first disk having a first radius with each first roller travelling at the same angular speed as the other first rollers, orbiting second rollers at a second angular speed around a substantially circular second disk having substantially the first radius, and increasing the pressure of fluid in tubing between one first roller and one second roller by causing the one or more first rollers to orbit at a first angular speed greater than the second angular speed so the one first roller moves along and fully compresses the tubing in a first section of the first disk, and simultaneously causing the one second roller to move along and fully compress the tubing in a first section of the second disk.
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公开(公告)号：US20170268998A1
公开(公告)日：2017-09-21
申请号：US15616712
申请日：2017-06-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox , Susan Hunter , Nathan Michael Gaskill-Fox , Kevin P. Raley , Richard A. Miles
CPC classification number: G01N21/64 , G01N15/1012 , G01N15/1427 , G01N15/1459 , G01N2015/1006 , G01N2015/1406 , G01N2015/149
Abstract: Disclosed is an automated method and apparatus for automatically setting a drop delay period by detecting calibration particles in a waste stream. The drop delay is incremented over a series of drop delays and the number of calibration particles in the waste stream is detected for each drop delay. The drop delay is selected which has the least number of calibration particles in the waste stream.
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公开(公告)号：US20170136430A1
公开(公告)日：2017-05-18
申请号：US15417131
申请日：2017-01-26
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox , Nathan Michael Gaskill-Fox
CPC classification number: G01N15/14 , B01F3/088 , B01F13/0059 , B01F15/0441 , G01N15/1404 , G01N2015/1006 , G01N2015/1409 , G05D11/131
Abstract: Disclosed is a system that can mix deionized water and concentrated sheath fluid to provide sheath fluid in a flow cytometer system having a desired concentration. Flow rates are low, which substantially match the flow rate of sheath fluid through the nozzle, so that turbulence and air bubbles are not formed in the sheath fluid. The available deionized water is then used for back flushing and removal of sample cells and deposited salts from the sheath fluid.
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15.发明授权公开(公告)号：US09162229B2
公开(公告)日：2015-10-20
申请号：US13923480
申请日：2013-06-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Nathan Michael Gaskill-Fox , Daniel N. Fox , Rodney C. Harris
CPC classification number: B01L9/52 , B01L9/06 , G01N15/14 , G01N35/1011 , G01N2015/149
Abstract: Disclosed is a collection sled for collecting a waste droplet stream 122 in a waste stream catcher that is located below sample collectors. Contamination of collected samples is reduced by collecting the waste droplet stream at a position that is below the sample collectors. A waste trough is provided that gets progressively larger in a downward direction, which prevents backsplash of waste fluid from the collection cavity. Standard sample collector tubes, as well as 8-well strips and microscope slides can be used with the collection sled to collect sample particles.
Abstract translation: 公开了一种用于在位于样品收集器下方的废物流捕集器中收集废液滴流122的收集筒。 通过在低于样品收集器的位置处收集废液滴流来减少收集的样品的污染。 提供了在向下方向逐渐变大的废物槽，其防止废液从收集腔中脱落。 标准样品收集器管以及8孔条和显微镜载玻片可与收集雪橇一起使用以收集样品颗粒。
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Patent Agency Ranking
公开(公告)号：US20130340795A1
公开(公告)日：2013-12-26
申请号：US13923148
申请日：2013-06-20
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Nathan Michael Gaskill-Fox , Daniel N. Fox , Rodney C. Harris
IPC: G01N11/02
CPC classification number: G01N11/02 , G01N15/1404 , G01N35/1004
Abstract: Disclosed is a two station system for a flow cytometer that includes a sample station and a wash station. During washing, the user has access to the sample station to insert a new sample. This increases the efficiency of the workflow process. Rotary clamps are used to automatically clamp the sample station and wash station to the system. A low volume pressurized cavity is used to bring the pressure of the sample to a desired pressure, which further increases productivity of the system. A transparent body is provided in the sample station so a user can view the sample during the sampling process. A backwash process is used to clean the sample injection tube and the sample uptake tube. In addition, the wash station is designed to rinse the outer surface of the sample uptake tube.
Abstract translation: 公开了一种用于流式细胞仪的两站系统，其包括采样站和洗涤站。 在洗涤期间，用户可以访问样品台以插入新的样品。 这提高了工作流程的效率。 旋转夹具用于自动将样品站和洗涤台夹在系统中。 使用低体积加压腔使样品的压力达到所需的压力，这进一步提高了系统的生产率。 在采样台中设置透明体，因此用户可以在采样过程中观察样品。 反冲洗过程用于清洗样品注射管和样品吸收管。 此外，洗涤台被设计成冲洗样品吸收管的外表面。
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公开(公告)号：US10648465B2
公开(公告)日：2020-05-12
申请号：US15345462
申请日：2016-11-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Nathan Michael Gaskill-Fox , Daniel Nelson Fox
Abstract: Methods and systems for pumping fluid through tubing are provided. Methods include orbiting one or more first rollers at multiple angular speeds around the periphery of a substantially circular first disk having a first radius with each first roller travelling at the same angular speed as the other first rollers, orbiting second rollers at a second angular speed around a substantially circular second disk having substantially the first radius, and increasing the pressure of fluid in tubing between one first roller and one second roller by causing the one or more first rollers to orbit at a first angular speed greater than the second angular speed so the one first roller moves along and fully compresses the tubing in a first section of the first disk, and simultaneously causing the one second roller to move along and fully compress the tubing in a first section of the second disk.
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公开(公告)号：US10508990B2
公开(公告)日：2019-12-17
申请号：US15616712
申请日：2017-06-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox , Susan Hunter , Nathan Michael Gaskill-Fox , Kevin P. Raley , Richard A. Miles
Abstract: Disclosed is an automated method and apparatus for automatically setting a drop delay period by detecting calibration particles in a waste stream. The drop delay is incremented over a series of drop delays and the number of calibration particles in the waste stream is detected for each drop delay. The drop delay is selected which has the least number of calibration particles in the waste stream.
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公开(公告)号：US20180313742A1
公开(公告)日：2018-11-01
申请号：US16030174
申请日：2018-07-09
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox , Nathan Michael Gaskill-Fox
IPC: G01N15/14
CPC classification number: G01N15/1404 , G01N1/28 , G01N1/286 , G01N2015/0065 , G01N2015/1006 , G01N2015/1406 , G01N2015/1409 , Y10T137/0324 , Y10T137/7287 , Y10T137/7303 , Y10T137/85978
Abstract: Disclosed is a sheath delivery system that uses a continuous flow of sheath fluid into a pressurized internal reservoir that substantially matches the outflow of sheath fluid through the nozzle of a flow cytometer. A substantially constant level of the sheath fluid is maintained. If the sheath fluid level falls below a desired level, or goes above a desired level, a dampened control system is used to reach the desired level. In addition, air pressure in the pressurized internal container is controlled so that an external sheath container can be removed and refilled with additional sheath fluid without stopping the sheath delivery system 100. Differences in pressure are detected by a droplet camera, which measures the droplet breakoff point to determine the pressure of the sheath fluid in the nozzle.
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公开(公告)号：US09927342B2
公开(公告)日：2018-03-27
申请号：US13923148
申请日：2013-06-20
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Nathan Michael Gaskill-Fox , Daniel N. Fox , Rodney C. Harris
CPC classification number: G01N11/02 , G01N15/1404 , G01N35/1004
Abstract: Disclosed is a two station system for a flow cytometer that includes a sample station and a wash station. During washing, the user has access to the sample station to insert a new sample. This increases the efficiency of the workflow process. Rotary clamps are used to automatically clamp the sample station and wash station to the system. A low volume pressurized cavity is used to bring the pressure of the sample to a desired pressure, which further increases productivity of the system. A transparent body is provided in the sample station so a user can view the sample during the sampling process. A backwash process is used to clean the sample injection tube and the sample uptake tube. In addition, the wash station is designed to rinse the outer surface of the sample uptake tube.
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