公开(公告)号：US20050178963A1

公开(公告)日：2005-08-18

申请号：US10508950

申请日：2003-04-02

申请人： Frank Londry ,  Bruce Collings ,  William Stott

发明人： Frank Londry ,  Bruce Collings ,  William Stott

IPC分类号： G01N27/62 ,  H01J49/00 ,  H01J49/42

CPC分类号： H01J49/4225 ,  H01J49/0063

摘要： In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution and efficiency. The technique includes trapping the ions in a linear ion trap, in which the background or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1 Volt (0-pk). The technique allows selective dissociation of ions with a high discrimination. High fragmentation efficiency may be achieved by superimposing a higher order multipole field onto the quadrupolar RF field used to trap the ions. The multipole field, preferably an octopole field, dampens the radial oscillatory motion of resonantly excited ions at the periphery of the trap. This reduces the probability that ions will eject radially from the trap thus increasing the probability of collision induced dissociation.

摘要翻译： 在质谱领域中，以分辨率和效率较高的方式分离离子的方法和装置。 该技术包括将离子捕获在线性离子阱中，其中背景或中性气体压力优选在10 -5 Torr量级。 被俘获的离子在相对较低的激发水平（例如小于1伏特（0-pk））下相对延长的时间段（例如超过50ms）被共振激发。 该技术允许高选择性地离解离子。 可以通过将高阶多极场叠加到用于捕获离子的四极RF场上来实现高碎裂效率。 多极场，优选是八极场，抑制在陷阱周边的共振激发的离子的径向振荡运动。 这降低了离子从陷阱径向射出的可能性，从而增加了碰撞诱导解离的可能性。

公开(公告)号：US20110174965A1

公开(公告)日：2011-07-21

申请号：US12359563

申请日：2009-01-26

申请人： Bruce Collings

发明人： Bruce Collings

IPC分类号： H01J49/10 ,  H01J49/26

CPC分类号： H01J49/0481 ,  H01J49/422

摘要： Methods for cooling ions retained in an ion trap are described. In various embodiments, a cooling gas is delivered into a linear ion trap causing a non-steady state pressure elevation in at least a portion of the trap above about 8×10−5 Torr for a duration less than the ion-retention time. In various embodiments, the duration of pressure elevation can be based upon a period of time required for an ion to lose a desired amount of its kinetic energy.

摘要翻译： 描述了保留在离子阱中的离子的冷却方法。 在各种实施方案中，将冷却气体输送到线性离子阱中，导致捕集阱的至少一部分中的非稳态压力升高高于约8×10 -5 Torr持续时间小于离子保留时间。 在各种实施方案中，压力升高的持续时间可以基于离子失去所需量的其动能所需的时间段。

公开(公告)号：US20050258362A1

公开(公告)日：2005-11-24

申请号：US11135426

申请日：2005-05-24

申请人： Bruce Collings

发明人： Bruce Collings

IPC分类号： B01D59/44 ,  H01J49/02 ,  H01J49/42

CPC分类号： H01J49/4225

摘要： The invention provides a multipole ion trap. The trap has a longitudinal axis. An oscillating on-axis potential is set up along the longitudinal axis, providing a potential well in which ions are trapped. In some embodiments, rods forming the poles are symmetrically and equidistantly positioned about the longitudinal axis and RF signal with different magnitudes are applied to the poles. In other embodiments, the rods are not positioned symmetrically about the longitudinal axis and the RF signals applied to the poles may have the same or different magnitudes. Poles used in the invention may include two or more rods. An ion trap according to the invention may include more than two poles, and in some embodiments, a third or additional pole may be added to provide the oscillating on-axis potential. The ion trap may be used mass selectively scan ions, fragment ions and to trap and separate differently charged ions, among other uses.

摘要翻译： 本发明提供一种多极离子阱。 陷阱具有纵轴。 沿纵轴设置振荡的轴上电位，提供潜在的阱，其中离子被捕获。 在一些实施例中，形成极的杆围绕纵向轴线对称和等距定位，并且具有不同幅度的RF信号施加到极。 在其他实施例中，杆不围绕纵轴对称地定位，并且施加到杆的RF信号可以具有相同或不同的量值。 本发明中使用的极可以包括两个或更多个棒。 根据本发明的离子阱可以包括多于两个极，并且在一些实施例中，可以添加第三或另外的极以提供振荡的轴上电位。 离子阱可以选择性地扫描离子，碎片离子，并捕获和分离不同电荷的离子等等。

公开(公告)号：US06833544B1

公开(公告)日：2004-12-21

申请号：US09857234

申请日：2002-04-01

申请人： Jennifer Campbell ,  Bruce Collings ,  Donald J. Douglas

发明人： Jennifer Campbell ,  Bruce Collings ,  Donald J. Douglas

IPC分类号： H01J4942

CPC分类号： H01J49/4225 ,  H01J49/004

摘要： A method of and apparatus for analyzing a stream of ions first subjects astream of ions to a first mass analysis step, to select ions having a mass-to-charge ratio in a first desired range; this enables a mass analyzer with highresolution to be used. The selected ions are then passed into a radiofrequency linear ion trap containing a gas. The trapped ions are caused to collide with the gas, either by being injected with a high axial energy or by application of external excitation to cause fragmentation. Fragment ions of a given mass-to-charge ratio can then be isolated and excited to produce fragments of fragments. This process can be repeated to give multiple steps of mass spectrometry, MSn. The fragment ions, and undissociated precursorions are then passed out of the linear ion trap and subjected to a further mass analysis step, for example in a time of flight device, to determine the mass spectrum of the ions.

摘要翻译： 用于分析离子流的方法和装置首先使离子流进入第一质量分析步骤，以选择质荷比在第一期望范围内的离子; 这使得能够使用具有高分辨率的质量分析器。 然后将选定的离子通入含有气体的射频线性离子阱中。 通过注入高轴向能量或通过施加外部激发来使被捕获的离子与气体碰撞以引起碎裂。 然后可以分离并激发给定质荷比的片段离子以产生碎片片段。 这个过程可以重复进行质谱的多步骤，MS n。 然后将片段离子和未解离的前体从线性离子阱中通过，并进行进一步的质量分析步骤，例如在飞行时间装置中，以确定离子的质谱。

公开(公告)号：US06054709A

公开(公告)日：2000-04-25

申请号：US986140

申请日：1997-12-05

申请人： Donald J. Douglas ,  Lars Konermann ,  Bruce Collings

发明人： Donald J. Douglas ,  Lars Konermann ,  Bruce Collings

IPC分类号： G01N27/62 ,  G01N35/08 ,  H01J49/04

CPC分类号： H01J49/0431 ,  G01N35/085

摘要： A method and apparatus are provided for determining rates and mechanisms of reactions in solution. The method comprises mixing reactants together and then passing the reactants, after mixing, to an electrospray or other ion source. The apparatus is configured so that the reaction time can be determined. This can either be by way of a capillary of known length and volume extending from a reaction tee or other mixing device, so that the reaction time can be determined from the capillary volume and flow rate, and/or by way of a container of fixed volume from which the reactants pass. From the ion source, ions pass into a mass spectrometer, where a mass spectrum is measured. By varying the reaction time, and measuring the different mass spectra, the rate of reaction can be determined.

摘要翻译： 提供了一种用于确定溶液中反应速率和机制的方法和装置。 该方法包括将反应物混合在一起，然后将混合后的反应物通入电喷雾或其它离子源。 该装置被配置成可以确定反应时间。 这可以通过已知长度的毛细管和从反应三通或其它混合装置延伸的体积，使得反应时间可以从毛细管体积和流速确定，和/或通过固定的容器确定 反应物通过的体积。 从离子源，离子进入质谱仪，其中测量质谱。 通过改变反应时间，测量不同的质谱，可以测定反应速率。