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公开(公告)号：US4906664A
公开(公告)日：1990-03-06
申请号：US144930
申请日：1988-01-15
IPC分类号： A61K31/23
CPC分类号： A61K31/23
摘要： A method of treating cancer cachexia syndrome has been discovered. Total parenteral nutrition using structured lipids in place of long chain fatty acids as the primary lipid source provides improvements in nitrogens balance, plasma serum albumin levels, and glucose clearance rate.
摘要翻译： 已经发现了治疗癌症恶病质综合征的方法。 使用结构化脂质代替长链脂肪酸作为主要脂质源的全肠外营养提供了氮的平衡，血浆血清白蛋白水平和葡萄糖清除率的改善。
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公开(公告)号：US4512974A
公开(公告)日：1985-04-23
申请号：US447984
申请日：1982-12-08
IPC分类号： A61K38/00 , C07K14/545 , A61K35/16
CPC分类号： C07K14/545 , A61K38/00
摘要： Exogenous LEM (Leukocyte Endogenous Mediator, also referred to as endogenous pyrogen) is parenterally administered to humans who are protein malnourished and are to undergo surgery, in order to preinitiate and then maintain the normal metabolic responses to the tissue damage occurring during surgery, and thereby promote the normal metabolic response by the human (patient).
摘要翻译： 外源性LEM（白细胞内源性调解子，也称为内源性热原）被肠胃外施用于蛋白质营养不良并将进行手术的人，以便预先诱导并且然后维持对在手术期间发生的组织损伤的正常代谢反应，由此 促进人（病人）的正常代谢反应。
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公开(公告)号：US5386832A
公开(公告)日：1995-02-07
申请号：US75662
申请日：1993-06-11
申请人： David A. Wagner , Martin A. Baker , Peter A. Burke , R. Amour Forse , John D. Palombo , Bruce R. Bistrian
发明人： David A. Wagner , Martin A. Baker , Peter A. Burke , R. Amour Forse , John D. Palombo , Bruce R. Bistrian
CPC分类号： A61K51/1206 , A61K51/0406
摘要： A test for determining hepatic function has been developed. This test uses oral administration of isotope labeled phenylalanine or tyrosine, particularly .sup.13 C-phenylalanine, in a rapid breath test. In the preferred mode, the breath sample is analyzed using a mass spectrometer and compared with a standard. The breath test provides a dynamic rather than static determination of hepatic function and can be used for both early and late stage liver problems.
摘要翻译： 已经开发了一种测定肝功能的试验。 该测试在快速呼吸试验中使用同位素标记的苯丙氨酸或酪氨酸，特别是13 C-苯丙氨酸的口服给药。 在优选模式中，使用质谱仪分析呼吸样本并与标准进行比较。 呼吸试验提供肝功能的动态而非静态测定，可用于早期和晚期肝脏问题。
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14.发明授权Method and composition for testing patients with metabolic depleting diseases 失效用于测试代谢性衰竭疾病患者的方法和组成
公开(公告)号：US5320846A
公开(公告)日：1994-06-14
申请号：US965609
申请日：1992-10-22
申请人： Bruce R. Bistrian , John D. Palombo
发明人： Bruce R. Bistrian , John D. Palombo
CPC分类号： A61K9/0029 , A61K31/70 , Y10S514/838 , Y10S514/893 , Y10S514/894
摘要： A method of treating patients with clinical disorder involving splanchnic disorders such as liver or gut dysfunction, the dysfunction being characterized by depletion of metabolic energy sources. The treatment involves the step of administering an effective amount of adenosine, or related nucleosides, to achieve and/or maintain normal metabolic levels of adenosine triphosphate (ATP) and/or its precursors in the patient's liver or other splanchnic organs. Administration may be as a total enteral nutritional diet, or as a dietary supplement. The invention includes a total enteral nutrition diet having nutritionally acceptable amounts of a lipid source, a protein source, a carbohydrate source, a vitamin source, and a mineral source, and an effective amount of adenosine to achieve normal metabolic levels of ATP and/or its precursors in ATP deficient organs of a recipient host.
摘要翻译： 一种治疗涉及内脏病例如肝脏或肠道功能障碍的临床病症的患者的方法，其功能障碍的特征在于代谢能源的消耗。 治疗涉及施用有效量的腺苷或相关核苷以达到和/或维持患者肝脏或其它内脏器官中三磷酸腺苷（ATP）和/或其前体的正常代谢水平的步骤。 管理可能是一种全面的肠内营养饮食，或作为膳食补充剂。 本发明包括具有营养可接受量的脂质源，蛋白质来源，碳水化合物源，维生素源和矿物源的总肠内营养饮食和有效量的腺苷以实现ATP和/或的正常代谢水平 其前体在受体宿主的ATP缺乏器官中。
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公开(公告)号：US4952606A
公开(公告)日：1990-08-28
申请号：US177763
申请日：1988-04-05
IPC分类号： A23L1/30 , A23C15/14 , A23D9/00 , A23D9/007 , A61K31/20 , A61K31/23 , A61P43/00 , C11C3/08 , C11C3/10
摘要： The present invention features a transesterification product of a mixture of fatty acids and triglycerides which include dairy fat as a primary component. This composition shows unexpected benefits in nutritional applications either as a food or as an enteral or parenteral supplement. The method of nutritional support using this composition is also disclosed.
摘要翻译： 本发明的特征在于脂肪酸和甘油三酯的混合物的酯交换产物，其包括乳脂肪作为主要成分。 该组合物作为食物或肠内或肠胃外补充剂在营养应用中显示出意想不到的益处。 还公开了使用该组合物的营养支持方法。
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公开(公告)号：US4847296A
公开(公告)日：1989-07-11
申请号：US28278
申请日：1987-03-20
IPC分类号： A61K31/23
CPC分类号： A61K31/23
摘要： Chemically synthesized structured triglycerides (lipids) for enteral administration as the lipid calorie source, is subjects undergoing severe metabolic stress.
摘要翻译： 用于肠内给药的化学合成的结构化甘油三酸酯（脂质）作为脂质卡路里来源，是经历严重代谢压力的受试者。
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17.发明授权Parenteral dietary supplement and method of minimizing effects of infection through diet 失效胃肠外营养补充剂和减少通过饮食感染影响的方法
公开(公告)号：US4820731A
公开(公告)日：1989-04-11
申请号：US207122
申请日：1988-06-15
IPC分类号： A61K31/20 , A23L33/00 , A61K31/047 , A61K31/23 , A61K35/60 , A61K36/00 , A61K36/28 , A61K36/48 , A61K38/00 , A61P31/04 , A61P31/12 , A61P33/10 , A61P37/00 , A61P43/00 , A61K31/22
摘要： Disclosed is a method of minimizing infection and minimizing the risks of infection in at risk animals and patients. A dietary supplement to accomplish this objective is also disclosed. The method includes the step of administering a diet rich in .omega.3 fatty acids, for example by adding a substantial proportion of fish oils to the diet. The dietary supplement is particularly well suited to patients receiving total parenteral nutrition. A parenteral diet or diet supplement containing a mixture of oils, one rich in .omega.3 fatty acids and the other rich in .omega.6 fatty acids is disclosed.
摘要翻译： 公开了一种最小化感染并最大限度地减少危险的动物和患者的感染风险的方法。 也披露了实现这一目标的膳食补充剂。 该方法包括施用富含ω3脂肪酸的饮食的步骤，例如通过将相当大比例的鱼油加入到饮食中。 膳食补充剂特别适合于接受全肠外营养的患者。 公开了含有富含ω-3脂肪酸和其它富含ω-6脂肪酸的油的混合物的肠胃外饮食或饮食补充剂。
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公开(公告)号：US4810726A
公开(公告)日：1989-03-07
申请号：US33346
申请日：1987-04-01
CPC分类号： A61K31/23 , A23D7/003 , A23D9/00 , Y10S514/893 , Y10S514/938 , Y10S514/943
摘要： A method of treating, and a diet composition for treating patients needing a controlled diet, wherein C.sub.12 fatty acids are the primary fatty acid source. Preferably lauric fats constitute 33-80% of the diet, while LCT's constitute no more than 20%. The lauric fats may be derived from a natural or fractionated kernel oil, selected from a group consisting of babassu oil, coconut oil, cohune oil, palm kernel oil, and tucum oil. A lipid emulsion with diverse additives is described.
摘要翻译： 一种治疗方法和用于治疗需要受控饮食的患者的饮食组合物，其中C12脂肪酸是主要的脂肪酸来源。 最好是月桂脂肪占饮食的33-80％，而LCT则不超过20％。 月桂酸脂肪可以衍生自选自巴巴苏油，椰子油，椰子油，棕榈仁油和土豆油的天然或分馏的仁油。 描述了具有不同添加剂的脂质乳剂。
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公开(公告)号：US6156738A
公开(公告)日：2000-12-05
申请号：US241004
申请日：1999-02-01
IPC分类号： A23L1/09 , A23L1/10 , A23L1/16 , A23L1/29 , A23L1/30 , A23L1/305 , A61K31/00 , A61K31/225 , A61K31/70 , A61K31/7004 , A61K31/7016 , A61K31/715 , A61K36/18 , A61K38/00 , A61P3/00 , A61P3/10
CPC分类号： A23L33/17 , A23L33/10 , A23L33/115 , A23L33/40 , A23V2002/00 , Y10S514/866
摘要： A novel diabetic supplement bar which includes about 10-60% by weight simple carbohydrate, about 1-25% by weight protein, about 2-40% by weight lipid and about 1-60%, preferably about 5-35% by weight complex carbohydrate. This formulation is particularly useful for the treatment or prevention of nighttime hypoglycemia in diabetic patients who require insulin injections.
摘要翻译： 一种新型糖尿病补充酒吧，其包含约10-60重量％的简单碳水化合物，约1-25重量％的蛋白质，约2-40重量％的脂质和约1-60重量％，优选约5-35重量％的复合物 糖类。 该制剂对于需要胰岛素注射的糖尿病患者的夜间低血糖的治疗或预防特别有用。
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公开(公告)号：US5993221A
公开(公告)日：1999-11-30
申请号：US847036
申请日：1997-05-01
申请人： Bruce R. Bistrian
发明人： Bruce R. Bistrian
CPC分类号： A23L33/12 , A23L33/40 , A23V2002/00 , Y10S514/943
摘要： A novel formulation which contains about 2-60% by calories of a C.sub.20 or longer .omega.3 fatty acid moiety and about 2-60% by calories of an arachidonic acid moiety has been developed. This formulation is particularly useful for restoring arachidonic acid levels, increasing immunity or minimizing risk of infection in critically ill patients, and treating functional essential fatty acid deficiency in patients suffering from end stage liver disease. A structured lipid which has a C.sub.20 or longer .omega.3 fatty acid moiety and an arachidonic acid moiety has also been developed.
摘要翻译： 已经开发了一种新的制剂，其通过卡路里含有约2-60％的C20或更长的ω-3脂肪酸部分和约2-60％的卡路里的花生四烯酸部分。 该制剂对于恢复花生四烯酸水平，增加免疫力或最小化危重病人感染风险以及治疗终末期肝病患者功能性必需脂肪酸缺乏症特别有用。 还开发了具有C20或更长的ω-3脂肪酸部分和花生四烯酸部分的结构化脂质。
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