公开(公告)号：US20240082223A1

公开(公告)日：2024-03-14

申请号：US18267202

申请日：2021-12-13

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Fabio RANCATI ,  Alessandro ACCETTA ,  Anna Maria CAPELLI ,  Daniele PALA ,  Roberta MAZZUCATO ,  Christine EDWARDS ,  Adele Elisa PASQUA

IPC: A61K31/4355 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D491/048 ,  C07D519/00

CPC classification number: A61K31/4355 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D491/048 ,  C07D519/00

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20200377500A1

公开(公告)日：2020-12-03

申请号：US16954964

申请日：2018-12-12

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Christine EDWARDS ,  Gurdip BHALAY ,  Patrizia TISSELLI

IPC: C07D471/04 ,  A61K31/496 ,  A61K9/00 ,  A61K45/06 ,  A61K31/407

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are meta tyrosine derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20200331912A1

公开(公告)日：2020-10-22

申请号：US16954968

申请日：2018-12-12

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Christine EDWARDS ,  Elizabeth Anne SKIDMORE

IPC: C07D471/04 ,  A61K45/06 ,  A61K9/00 ,  A61K31/4375 ,  A61K31/444

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are oxidazole derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20170119753A1

公开(公告)日：2017-05-04

申请号：US15404897

申请日：2017-01-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Fabio RANCATI ,  Andrea RIZZI ,  Laura CARZANIGA ,  Ian LINNEY ,  Chris KNIGHT ,  Wolfgang SCHMIDT

IPC: A61K31/4709 ,  A61K31/5386 ,  A61K31/496 ,  A61K9/00 ,  A61K31/4704

CPC classification number: A61K31/4709 ,  A61K9/0073 ,  A61K31/4704 ,  A61K31/496 ,  A61K31/5386 ,  A61K45/06 ,  C07D215/227 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D453/02 ,  C07D453/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10

Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating broncho-obstructive and inflammatory diseases.

公开(公告)号：US20240425482A1

公开(公告)日：2024-12-26

申请号：US18702454

申请日：2022-10-17

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Eleonora GHIDINI ,  Nicolò IOTTI ,  Roberta MAZZUCATO ,  Stefano LEVANTO ,  Ben Paul WHITTAKER

IPC: C07D401/14 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  C07D413/14 ,  C07D487/10

Abstract: The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240199635A1

公开(公告)日：2024-06-20

申请号：US18283867

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZi ,  Keith Christopher KNIGHT ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  Toby Matthew Grover MULLINS ,  Ben Paul WHITTAKER

IPC: C07D495/04 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/541

CPC classification number: C07D495/04 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/541

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240190847A1

公开(公告)日：2024-06-13

申请号：US18283855

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  Toby Matthew Grover MULLINS

IPC: C07D403/14 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  C07D401/14

CPC classification number: C07D403/14 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  C07D401/14

Abstract: The present invention relates to compounds of general formula (I) inhibiting DDR1 and DDR2. Particularly, the invention relates to compounds that are indoline derivatives, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of DDRs, in particular fibrosis.

公开(公告)号：US20240092792A1

公开(公告)日：2024-03-21

申请号：US18267222

申请日：2021-12-13

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Fabio RANCATI ,  Alessandro ACCETTA ,  Anna Maria CAPELLI ,  Daniele PALA ,  Christine EDWARDS ,  Adele Elisa PASQUA ,  Prashant Bhimrao KAPADNIS ,  Arnaud Jean Francois Auguste CHEGUILLAUME

IPC: C07D491/048 ,  A61K45/06 ,  C07D519/00

CPC classification number: C07D491/048 ,  A61K45/06 ,  C07D519/00

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20240092791A1

公开(公告)日：2024-03-21

申请号：US18267185

申请日：2021-12-13

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Fabio RANCATI ,  Alessandro ACCETTA ,  Anna Maria CAPELLI ,  Daniele PALA ,  Christine EDWARDS ,  Adele Elisa PASQUA ,  Prashant Bhimrao KAPADNIS ,  Arnaud Jean Francois Auguste CHEGUILLAUME ,  David Edward CLARK

IPC: C07D491/048 ,  A61P11/08

CPC classification number: C07D491/048 ,  A61P11/08

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20230227447A1

公开(公告)日：2023-07-20

申请号：US17927762

申请日：2021-05-24

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Anna KARAWAJCZYK ,  Bartosz Pawel GUT

IPC: C07D471/04 ,  C07D487/04 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/42 ,  C07D213/81 ,  C07D239/26 ,  C07D519/00 ,  C07D213/74 ,  C07D401/04

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/42 ,  C07D213/81 ,  C07D239/26 ,  C07D519/00 ,  C07D213/74 ,  C07D401/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting DDR1 and DDR2, particularly the invention relates to compounds that are benzylamine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of DDRs, in particular fibrosis.