公开(公告)号：US11137342B2

公开(公告)日：2021-10-05

申请号：US15565268

申请日：2016-04-08

Applicant: Cytiva Sweden AB

Inventor： Henrik Svanberg ,  Hanno Ehring ,  Erik Nils Ostlund

IPC: G01N21/05 ,  G02B6/38 ,  G02B6/36 ,  G02B6/42

Abstract: The present invention relates to an optical flow cell (1) for a measuring device, having an input light guide with a light exit surface, an output light guide with a light entrance surface, said input light guide and output light guide being integrated with a holder (30) to form optical flow cell (1), and wherein the holder (30) extends along a first axis (A) and has a through hole (31) for receiving a flow of a sample fluid, said through hole (31) being transversal to said first axis (A), and the input light guide and output light guide further are arranged in said holder (30) so that the light exit surface and the light entrance surface extend into said through hole (31) and are arranged to be in optical alignment with each other and at a first distance from each other. The invention also relates to a measuring device having at least one optical flow cell (1).

公开(公告)号：US20210096059A1

公开(公告)日：2021-04-01

申请号：US16078727

申请日：2017-02-27

Applicant: Cytiva Sweden AB

Inventor： Hanno Ehring

IPC: G01N21/03 ,  G01N21/33 ,  G01N21/05

Abstract: The present invention relates to an apparatus for measuring the absorbance of a substance in a solution, comprising at least one sample cell arranged to contain said solution that is at least partially transparent to light of a predefined wavelength spectrum, at least two light passages through said at least one sample cell, each of said light passages having a known path length, an LED light source arrangement comprising at least two LEDs, each arranged to emit a light output with a wavelength within said predefined wavelength spectrum, wherein a plurality of optical fibers, one for each light passage, is arranged at each LED for receiving said light output and guiding it to the light passages. The invention also relates to a method for measuring the absorbance of a substance in a solution.

公开(公告)号：US12117389B2

公开(公告)日：2024-10-15

申请号：US17487722

申请日：2021-09-28

Applicant: Cytiva Sweden AB

Inventor： Henrik Svanberg ,  Hanno Ehring ,  Erik Nils Ostlund

IPC: G01N21/05 ,  G02B6/36 ,  G02B6/38 ,  G02B6/42

CPC classification number: G01N21/05 ,  G02B6/3616 ,  G02B6/3644 ,  G02B6/3825 ,  G02B6/3861 ,  G02B6/4219 ,  G01N2021/052 ,  G01N2201/0664 ,  G01N2201/0668 ,  G01N2201/0813 ,  G01N2201/086 ,  G02B6/36

Abstract: The present invention relates to an optical flow cell for a measuring device, having an input light guide with a light exit surface, an output light guide with a light entrance surface, said input light guide and output light guide being integrated with a holder to form an optical flow cell, and wherein the holder extends along a first axis and has a through hole for receiving a flow of a sample fluid, said through hole being transversal to said first axis, and the input light guide and output light guide further are arranged in said holder so that the light exit surface and the light entrance surface extend into said through hole and are arranged to be in optical alignment with each other and at a first distance from each other. The invention also relates to a measuring device having at least one optical flow cell.

公开(公告)号：US20230221250A1

公开(公告)日：2023-07-13

申请号：US17997641

申请日：2021-05-17

Applicant: CYTIVA SWEDEN AB

Inventor： Hanno Ehring

IPC: G01N21/59 ,  G01N21/31 ,  G01N21/45

CPC classification number: G01N21/5907 ,  G01N21/314 ,  G01N21/45 ,  G01N2021/052

Abstract: A method and instrument for determining optical density of a solution is disclosed. A flow cell 1 having at least three light paths (4a, 4b, 4c) is provided (100), wherein each light path has a respective predetermined path length, l. Absorbance readings are taken (400), A, of the solution at the at least three light paths (4a, 4b, 4c). For each pair of light paths, a slope, αc, is calculated (500) by dividing a difference in absorbance reading, ΔA, with a difference in path length, Δl. The calculated slopes, αc, are compared (600), and a) if the calculated slopes, αc, are the same, the slope is used for determining (700) optical density of the solution, or b) if he calculated slopes, αc, are not the same, the steepest slope of the calculated slopes is used for determining (701a) optical density of the solution, or the slope of the calculated slopes being in the range of an absorbance reading of 0.01 to 2 is used for determining (701b) optical density of the solution

公开(公告)号：US20230221241A1

公开(公告)日：2023-07-13

申请号：US17997644

申请日：2021-06-10

Applicant: CYTIVA SWEDEN AB

Inventor： Hanno Ehring ,  Klaus Gebauer

IPC: G01N21/05 ,  G01N21/15

CPC classification number: G01N21/05 ,  G01N21/15 ,  G01N2021/052 ,  G01N2201/0245

Abstract: Disclosed is an optical flow cell (100, 300) and a method (400) for bioprocessing applications. The optical flow cell (100, 300) comprises a fluid inlet (102, 302), a fluid outlet (104, 304), and a fluid flow channel (106, 306) provided between said fluid inlet (102, 302) and said fluid outlet (104, 304). The optical flow cell (100, 300) also comprises an output optical waveguide (108, 308) configured to emit light into said fluid flow channel (106, 306), and a collector optical waveguide (110, 310) configured to collect light from said fluid flow channel (106, 306). An optical pathlength adjuster (120, 320) for varying the optical pathlength (130, 330) between said output optical waveguide (108, 308) and said collector optical waveguide (110, 310) is also provided.

公开(公告)号：US20220018757A1

公开(公告)日：2022-01-20

申请号：US17487722

申请日：2021-09-28

Applicant: Cytiva Sweden AB

Inventor： Henrik Svanberg ,  Hanno Ehring ,  Erik Nils Ostlund

IPC: G01N21/05 ,  G02B6/38 ,  G02B6/36 ,  G02B6/42

Abstract: The present invention relates to an optical flow cell for a measuring device, having an input light guide with a light exit surface, an output light guide with a light entrance surface, said input light guide and output light guide being integrated with a holder to form an optical flow cell, and wherein the holder extends along a first axis and has a through hole for receiving a flow of a sample fluid, said through hole being transversal to said first axis, and the input light guide and output light guide further are arranged in said holder so that the light exit surface and the light entrance surface extend into said through hole and are arranged to be in optical alignment with each other and at a first distance from each other. The invention also relates to a measuring device having at least one optical flow cell.

公开(公告)号：US20210208058A1

公开(公告)日：2021-07-08

申请号：US17056543

申请日：2019-05-29

Applicant: Cytiva Sweden AB

Inventor： Hanno Ehring ,  Mats Lundkvist ,  David Carl Martin Bergman ,  Andreas Marcstrom

IPC: G01N21/05 ,  G01N21/85 ,  G01N21/03

Abstract: Disclosed is an optical flow cell (300′) comprising: a housing (910) forming; an enclosed and elongated fluid channel (920) arranged along a first axis (923); a first light guide (961) and a second light guide (962) generally concentrically arranged along a second axis (970) and on opposite side walls of the fluid channel, said first and second light guides having ends (961c,962c) removed in situ to provide a sensing gap (d).