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21 条记录 (耗时 0.046 秒)

    Detection of neurodegenerative disease
    14.
    发明授权
    Detection of neurodegenerative disease 有权
    检测神经变性疾病

    公开(公告)号：US08354236B2

    公开(公告)日：2013-01-15

    申请号：US12412015

    申请日：2009-03-26

    申请人： Virginia M. Y. Lee ,  John Q. Trojanowski

    发明人： Virginia M. Y. Lee ,  John Q. Trojanowski

    IPC分类号： G01N33/53 ,  G01N33/566 ,  G01N33/567

    CPC分类号： C07K16/18 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/52

    摘要： Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods for diagnosing a neurodegenerative disease in a subject, and methods for determining the efficacy of a drug against a neurodegenerative disease. Novel antibodies that bind to TDP-43 are also provided.

    摘要翻译： 提供了评估受试者中缺乏或存在神经变性疾病的方法，包括在受试者的组织样品中表征TDP-43。 还公开了用于诊断受试者中的神经变性疾病的方法以及用于测定药物抵抗神经变性疾病的功效的方法。 还提供了结合TDP-43的新型抗体。

    Compositions and methods for producing and using homogenous neuronal cell transplants
    17.
    发明授权
    Compositions and methods for producing and using homogenous neuronal cell transplants 失效
    用于产生和使用均质神经元细胞移植的组合物和方法

    公开(公告)号：US07011827B2

    公开(公告)日：2006-03-14

    申请号：US09862204

    申请日：2001-05-22

    申请人： Virginia M.-Y. Lee ,  John Q. Trojanowski

    发明人： Virginia M.-Y. Lee ,  John Q. Trojanowski

    IPC分类号： A61K35/00

    CPC分类号： A61K35/30 ,  A01K67/0271 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0619 ,  C12N2517/02

    摘要： Methods of treating individuals suspected of suffering from diseases, conditions or disorders of the Central Nervous System including nerve damage are provided wherein stable, homogeneous post-mitotic human neurons are into the individual's brain or at or near a site of nerve damage. Pharmaceutical compositions of stable, homogeneous post-mitotic human neurons and a pharmaceutically acceptable medium are also disclosed. Methods of generating non-human animal models of human CNS diseases, conditions or disorders by implanting stable, homogeneous post-mitotic human neurons into the brain of a non-human animal are disclosed. Non-human animals eith stable, homogeneous post-mitotic human neurons implanted in their brain are also disclosed.

    摘要翻译： 提供了治疗怀疑患有包括神经损伤的中枢神经系统的疾病，病症或病症的个体的方法，其中稳定的，均质的后有丝分裂的人类神经元进入个体的大脑或神经损伤部位或附近。 还公开了稳定的，均质的有丝分裂后神经元和药学上可接受的培养基的药物组合物。 公开了通过将稳定的，均质的后有丝分裂的人类神经元植入非人动物的脑中而产生人类CNS疾病，病症或障碍的非人动物模型的方法。 还公开了植入其大脑中的稳定的，均质后有丝分裂的人类神经元的非人类动物。

    Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
    19.
    发明授权
    Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments 失效
    筛选阿尔茨海默病或与成对螺旋丝聚积相关疾病的方法

    公开(公告)号：US5733734A

    公开(公告)日：1998-03-31

    申请号：US145827

    申请日：1993-10-29

    申请人： John Q. Trojanowski ,  Virginia M-Y. Lee

    发明人： John Q. Trojanowski ,  Virginia M-Y. Lee

    IPC分类号： G01N33/68 ,  G01N33/53 ,  C07K16/18

    CPC分类号： G01N33/6896 ,  G01N2800/2821 ,  Y10S435/96 ,  Y10S436/811

    摘要： Substantially purified antibodies, including substantially purified monoclonal antibodies, which are specifically reactive with .tau. that has an abnormally phosphorylated serine in the sequence LysSerProVal SEQ ID NO:3 are disclosed. Methods of screening persons for diseases associated with pair helical filaments, including Alzheimer's disease, by detection of .tau. that has an abnormally phosphorylated serine in the sequence LysSerProVal SEQ ID NO:3 in test samples taken from such persons and test kits useful to perform such methods are disclosed.

    摘要翻译： 公开了基本上纯化的抗体，包括与序列LysSerProVal SEQ ID NO：3中具有异常磷酸化丝氨酸的tau特异性反应的基本纯化的单克隆抗体。 通过检测来自这些人的测试样品中的序列LysSerProVal SEQ ID NO：3中具有异常磷酸化丝氨酸的tau，通过检测与对对螺旋丝相关的疾病（包括阿尔茨海默氏病）筛选人的方法和用于执行这些方法的测试试剂盒 被披露。

    Method of stabilizing microtubules
    20.
    发明授权
    Method of stabilizing microtubules 失效
    稳定微管的方法

    公开(公告)号：US5580898A

    公开(公告)日：1996-12-03

    申请号：US248234

    申请日：1994-05-24

    申请人： John Q. Trojanowski ,  Virginia M-Y. Lee

    发明人： John Q. Trojanowski ,  Virginia M-Y. Lee

    IPC分类号： A61K31/337 ,  A61K31/335 ,  A01N43/02

    CPC分类号： A61K31/337 ,  Y10S436/811

    摘要： A method of stabilizing microtubules which are destabilized due to insufficient levels of normal human tau protein is disclosed. The method comprises the steps of contacting a microtubule that is destablizing due to a deficiency in normal tau protein with an amount of taxol sufficient to stabilize microtubules.

    摘要翻译： 公开了一种稳定由于正常人tau蛋白水平不足而不稳定的微管的方法。 该方法包括以下步骤：将由于正常tau蛋白缺乏导致的正在死亡的微管与足以稳定微管的紫杉醇的量接触。