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21 条记录 (耗时 0.029 秒)

    Rat comprising straight filaments in its brain
    4.
    发明授权
    Rat comprising straight filaments in its brain 失效
    大鼠在其大脑中包含直线细丝

    公开(公告)号：US5849988A

    公开(公告)日：1998-12-15

    申请号：US261810

    申请日：1994-06-17

    申请人： John Q. Trojanowski ,  Virginia M.-Y. Lee ,  Ryong-Woon Shin

    发明人： John Q. Trojanowski ,  Virginia M.-Y. Lee ,  Ryong-Woon Shin

    IPC分类号： A01K67/027 ,  C07K14/47 ,  C12N5/00 ,  A61K38/00 ,  A61K49/00 ,  C12N15/00

    CPC分类号： C07K14/4711 ,  A01K67/027 ,  Y10S530/839

    摘要： Methods of generating a rat having A.beta. deposits in the brain of the rat by injecting an amount of human A68 protein sufficient to result in formation of the deposits and subsequently examining the rat for the formation of the deposits are disclosed. Rats characterized by the presence of A.beta. deposits similar to those found in individuals with Alzheimer's disease are also disclosed. Methods of screening test compositions for prophylactic or therapeutic activity by generating a rat having A.beta. deposits in its brain, treating the animal with the test composition and examining the animal for therapeutic or prophylactic effectiveness are also disclosed.

    摘要翻译： 公开了通过注射足以导致沉积物形成并随后检查大鼠以形成沉积物的量的人A68蛋白来产生大鼠脑中具有Aβ沉积物的大鼠的方法。 特征在于存在类似于在阿尔茨海默病个体中发现的Aβ的沉积物的大鼠也被公开。 还公开了通过在其脑中产生具有Aβ沉积物的大鼠来筛选测试组合物用于预防或治疗活性的方法，用测试组合物治疗动物并检查动物的治疗或预防效力。

    Method of detecting abnormally phosphorylated tau(.tau.)
    5.
    发明授权
    Method of detecting abnormally phosphorylated tau(.tau.) 失效
    检测异常磷酸化tau（tau）的方法

    公开(公告)号：US5601985A

    公开(公告)日：1997-02-11

    申请号：US495308

    申请日：1995-06-27

    申请人： John Q. Trojanowski ,  Virginia M-Y. Lee

    发明人： John Q. Trojanowski ,  Virginia M-Y. Lee

    IPC分类号： G01N33/68 ,  G01N33/53

    CPC分类号： G01N33/6896 ,  G01N2800/2821 ,  Y10S435/96 ,  Y10S436/811

    摘要： Antibodies specifically reactive with an abnormally phosphorylated peptide comprising SEQ ID NO: 3 wherein a serine in SEQ ID NO: 3 is abnormally phosphorylated are provided. Methods of detecting abnormally phosphorylated .tau. in a test sample and methods of diagnosing Alzheimer's Disease with these antibodies are also provided.

    摘要翻译： 提供了与包含SEQ ID NO：3的异常磷酸化肽特异性反应的抗体，其中SEQ ID NO：3中的丝氨酸异常磷酸化。 还提供了测试样品中异常磷酸化tau检测方法和用这些抗体诊断阿尔茨海默病的方法。

    Detection of neurodegenerative disease
    8.
    发明授权
    Detection of neurodegenerative disease 有权
    检测神经变性疾病

    公开(公告)号：US08354236B2

    公开(公告)日：2013-01-15

    申请号：US12412015

    申请日：2009-03-26

    申请人： Virginia M. Y. Lee ,  John Q. Trojanowski

    发明人： Virginia M. Y. Lee ,  John Q. Trojanowski

    IPC分类号： G01N33/53 ,  G01N33/566 ,  G01N33/567

    CPC分类号： C07K16/18 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/52

    摘要： Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods for diagnosing a neurodegenerative disease in a subject, and methods for determining the efficacy of a drug against a neurodegenerative disease. Novel antibodies that bind to TDP-43 are also provided.

    摘要翻译： 提供了评估受试者中缺乏或存在神经变性疾病的方法，包括在受试者的组织样品中表征TDP-43。 还公开了用于诊断受试者中的神经变性疾病的方法以及用于测定药物抵抗神经变性疾病的功效的方法。 还提供了结合TDP-43的新型抗体。

    Compositions and methods for producing and using homogenous neuronal cell transplants
    10.
    发明授权
    Compositions and methods for producing and using homogenous neuronal cell transplants 失效
    用于产生和使用均质神经元细胞移植的组合物和方法

    公开(公告)号：US07011827B2

    公开(公告)日：2006-03-14

    申请号：US09862204

    申请日：2001-05-22

    申请人： Virginia M.-Y. Lee ,  John Q. Trojanowski

    发明人： Virginia M.-Y. Lee ,  John Q. Trojanowski

    IPC分类号： A61K35/00

    CPC分类号： A61K35/30 ,  A01K67/0271 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0619 ,  C12N2517/02

    摘要： Methods of treating individuals suspected of suffering from diseases, conditions or disorders of the Central Nervous System including nerve damage are provided wherein stable, homogeneous post-mitotic human neurons are into the individual's brain or at or near a site of nerve damage. Pharmaceutical compositions of stable, homogeneous post-mitotic human neurons and a pharmaceutically acceptable medium are also disclosed. Methods of generating non-human animal models of human CNS diseases, conditions or disorders by implanting stable, homogeneous post-mitotic human neurons into the brain of a non-human animal are disclosed. Non-human animals eith stable, homogeneous post-mitotic human neurons implanted in their brain are also disclosed.

    摘要翻译： 提供了治疗怀疑患有包括神经损伤的中枢神经系统的疾病，病症或病症的个体的方法，其中稳定的，均质的后有丝分裂的人类神经元进入个体的大脑或神经损伤部位或附近。 还公开了稳定的，均质的有丝分裂后神经元和药学上可接受的培养基的药物组合物。 公开了通过将稳定的，均质的后有丝分裂的人类神经元植入非人动物的脑中而产生人类CNS疾病，病症或障碍的非人动物模型的方法。 还公开了植入其大脑中的稳定的，均质后有丝分裂的人类神经元的非人类动物。