利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

42 条记录 (耗时 0.112 秒)

    Glycopegylated erythropoietin
    11.
    发明申请
    Glycopegylated erythropoietin 有权
    糖基化促红细胞生成素

    公开(公告)号：US20050143292A1

    公开(公告)日：2005-06-30

    申请号：US10997405

    申请日：2004-11-24

    申请人： Shawn DeFrees ,  Robert Bayer ,  David Zopf

    发明人： Shawn DeFrees ,  Robert Bayer ,  David Zopf

    IPC分类号： A61K20060101 ,  A61K38/00 ,  A61K38/18 ,  C07K7/00 ,  C07K14/505

    CPC分类号： C07K14/505 ,  A61K38/00 ,  A61K47/60 ,  C07H19/10

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供红细胞生成素和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    Manufacturing support and shipping package
    13.
    发明授权
    Manufacturing support and shipping package 失效
    制造支持和运输包装

    公开(公告)号：US4531639A

    公开(公告)日：1985-07-30

    申请号：US532318

    申请日：1983-09-15

    申请人： David Zopf

    发明人： David Zopf

    IPC分类号： B65D81/02 ,  B65D85/30

    CPC分类号： B65D81/022

    摘要： A packaging article for the handling of sensitive objects, that includes a semi-rigid foam case in which an elastomeric pad has been molded. A rigid support base is also molded within the case and supported on the elastomeric pad. The support base is covered by a release agent which prevents the casing material from permanently adhering to the support base, thus allowing the support base to shift within the case. A handling stand is secured to the sensitive object and may be used to support the object outside of the case. The handling stand mounts on the support base so that the support base handling stand assembly with the sensitive object mounted thereon floats or shifts within the case on the elastomeric pad without any other object surface contacting the support base.

    摘要翻译： 用于处理敏感物体的包装制品，其包括其中已经模制弹性垫的半刚性泡沫壳体。 刚性支撑底座也在壳体内模制并支撑在弹性垫上。 支撑底座由防脱壳剂覆盖，防止外壳材料永久地粘附到支撑基座上，从而允许支撑基座在壳体内移动。 处理台被固定到敏感物体上，并且可以用于将物体支撑在壳体外部。 处理台安装在支撑基座上，使得安装有敏感物体的支撑基座处理台组件在弹性垫上的壳体内漂浮或移动，而没有任何其它物体表面接触支撑基座。

    Glycopegylated Erythropoietin
    18.
    发明申请
    Glycopegylated Erythropoietin 审中-公开
    糖基化红细胞生成素

    公开(公告)号：US20070254834A1

    公开(公告)日：2007-11-01

    申请号：US10579621

    申请日：2004-11-24

    申请人： Shawn DeFrees ,  Robert Bayer ,  David Zopf

    发明人： Shawn DeFrees ,  Robert Bayer ,  David Zopf

    IPC分类号： A61K38/16 ,  A61P7/00 ,  C07K1/00

    CPC分类号： C07K14/505 ,  A61K38/00 ,  A61K47/60 ,  C07H19/10

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供红细胞生成素和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    One pot desialylation and glycopegylation of therapeutic peptides
    20.
    发明申请
    One pot desialylation and glycopegylation of therapeutic peptides 审中-公开
    治疗性肽的一罐去唾液酸化和糖基化

    公开(公告)号：US20070105755A1

    公开(公告)日：2007-05-10

    申请号：US11580669

    申请日：2006-10-13

    申请人： Shawn DeFrees ,  David Zopf ,  Susann Taudte ,  Walter Willett ,  Robert Bayer ,  Matthew Kalo

    发明人： Shawn DeFrees ,  David Zopf ,  Susann Taudte ,  Walter Willett ,  Robert Bayer ,  Matthew Kalo

    IPC分类号： A61K38/36 ,  C12P21/06

    CPC分类号： C12P21/005 ,  A61K38/4846

    摘要： The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

    摘要翻译： 本发明提供肽和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。