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11.发明授权Potentiostatic circuit arrangement on a biosensor for digitisation of the measured current 有权用于数字化测量电流的生物传感器上的静电电路布置公开(公告)号：US07914655B2
公开(公告)日：2011-03-29
申请号：US10556731
申请日：2004-05-11
IPC分类号： G01N27/327 , G01R19/12
CPC分类号： G01R19/252 , C12Q1/6825 , G01N27/3276
摘要： A circuit arrangement, an electrochemical sensor, a sensor arrangement, and a method for processing a current signal provided by a sensor electrode are disclosed. The circuit arrangement includes a sensor electrode, a first circuit unit, electrically coupled to the sensor electrode and a second circuit unit, including a first capacitor, whereby the first circuit arrangement is embodied to hold the electrical potential of the sensor electrode in a given first reference range about a set electrical potential and, when the sensor electrode potential falls outside the first reference range, the first capacitor and the sensor electrode are coupled such that a matching of the electrical potentials is possible. The second circuit unit is embodied such that, when the electrical potential of the first capacitor falls outside a second reference range, this event is detected and the first capacitor brought to a first electrical reference potential.
摘要翻译： 公开了电路装置，电化学传感器，传感器装置和用于处理由传感器电极提供的电流信号的方法。 电路装置包括传感器电极，电耦合到传感器电极的第一电路单元和包括第一电容器的第二电路单元，由此第一电路装置被实施为将传感器电极的电势保持在给定的第一 参考范围关于设定的电位，并且当传感器电极电位落在第一参考范围之外时，第一电容器和传感器电极被耦合，使得电位的匹配是可能的。 实施第二电路单元，使得当第一电容器的电位落在第二参考范围之外时，检测到该事件，并将第一电容器带到第一电参考电位。
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公开(公告)号：US07756560B2
公开(公告)日：2010-07-13
申请号：US11002736
申请日：2004-12-02
IPC分类号： A61B5/05
CPC分类号： C12M1/00 , C12Q1/6837 , G01N1/00 , G01N27/3276 , C12Q2565/607
摘要： Sensor arrangement having capture molecules immobilized on any of three sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules; a control circuit for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes; a detection device, wherein in a first operating state a reference liquid is introduced into the sensor arrangement and a reference value of an electrical signal is detected at the selected sensor electrode, and in a second operating state an analyte possibly having molecules to be detected is introduced into the sensor arrangement and a sensor value of the electrical signal is detected at the selected sensor electrode; and an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.
摘要翻译： 传感器布置，其具有固定在三个传感器电极中的任一个上的捕获分子，其中待检测的分子可与捕获分子杂交; 控制电路，用于将第一电信号施加到所选择的传感器电极，并同时向至少两个其它传感器电极施加第二电信号; 检测装置，其中在第一操作状态下，将参考液体引入所述传感器装置，并且在所选择的传感器电极处检测到电信号的参考值，并且在第二操作状态下，可能具有待检测分子的分析物是 引入到传感器装置中，并且在所选择的传感器电极处检测电信号的传感器值; 以及评估电路，其基于参考值和传感器值确定在所选择的传感器电极处是否发生杂交事件。
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13.发明申请Planar sensor arrangement, sensor array and method for the production of a planar-sensor arrangement 有权平面传感器布置，传感器阵列和生产平面传感器装置的方法公开(公告)号：US20070181424A1
公开(公告)日：2007-08-09
申请号：US11631380
申请日：2005-06-30
IPC分类号： G01N33/487
CPC分类号： G01N33/5438 , G01N27/02 , G01N27/3276
摘要： A planar-sensor arrangement is disclosed, which is used to detect particles possibly contained in an analyte. The sensor element includes a substrate, a first planar-sensor electrode and a second planar-sensor electrode which are formed on and/or in the substrate and whereon catcher molecules can be immobilised. The first sensor-electrode and the second sensor-electrode are divided, respectively, into a plurality of planar sensor-electrode partial areas. The sensor electrode partial areas of the first sensor electrode and the sensor electrode partial areas of the second sensor electrode are arranged in an alternating manner in two dimensions on the surface plane of the substrate. The sensor element also includes a wiring structure by which at least one part of the sensor electrode partial areas of the first sensor electrode are electrically coupled together, and by which at least one part of the sensor-electrode partial areas of the second sensor electrode are electrically coupled together.
摘要翻译： 公开了一种平面传感器装置，其用于检测可能包含在分析物中的颗粒。 传感器元件包括衬底，第一平面传感器电极和第二平面传感器电极，其形成在衬底上和/或衬底中，并且捕获剂分子可以被固定。 第一传感器电极和第二传感器电极分别分成多个平面传感器电极部分区域。 第一传感器电极的传感器电极部分区域和第二传感器电极的传感器电极部分区域在基板的表面上以二维交替排列。 传感器元件还包括布线结构，通过该布线结构，第一传感器电极的传感器电极部分区域的至少一部分电耦合在一起，并且第二传感器电极的传感器电极部分区域的至少一部分 电耦合在一起。
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14.发明申请公开(公告)号：US20080073225A1
公开(公告)日：2008-03-27
申请号：US11630975
申请日：2005-06-29
申请人： Christian Paulus
发明人： Christian Paulus
IPC分类号： G01F1/64
CPC分类号： G01N33/5438 , G01N27/3277
摘要： A sensor array with at least three electrodes and a switching unit is disclosed, as well as a process for operating such a sensor array for implementing an electrochemical analysis process. The at least three electrodes can be selectively switched as counter-electrodes or as a working electrode which can be electrically coupled to an electrolytic analyte. The at least three electrodes are set up in such a way that sensor events occur at an electrode switched as working electrode in the electrolyte solution, in the presence of the electrolytic analyte. The electrodes which are not required as working electrodes at a particular point in time for detecting the electrolytic analyte can thus be switched together to form the counter-electrode of the sensor array, thus dispensing with the need for a separate counter-electrode.
摘要翻译： 公开了具有至少三个电极和开关单元的传感器阵列，以及用于操作用于实现电化学分析过程的这种传感器阵列的方法。 可以将至少三个电极选择性地切换为对电极或作为电耦合到电解分析物的工作电极。 至少三个电极被设置成使得传感器事件发生在电解质溶液存在下在电解质溶液中作为工作电极切换的电极处。 因此，在用于检测电解分析物的特定时间点不需要作为工作电极的电极可以一起切换以形成传感器阵列的对电极，从而分配需要单独的对电极。
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15.发明授权Measuring cell and measuring field comprising measuring cells of this type, use of a measuring and use of a measuring field 有权测量电池和测量领域包括测量这种类型的电池，使用测量和使用测量领域公开(公告)号：US07084641B2
公开(公告)日：2006-08-01
申请号：US10754909
申请日：2004-01-09
CPC分类号： G11C27/024 , G01N27/4148 , G01N33/48728
摘要： A measuring cell for recording an electrical potential of an analyte situated on the measuring cell. The measuring cell has a sensor, a layer arranged above the sensor and electrically insulating the analyte from the sensor, and an amplifier circuit connected to the sensor on a substrate and having an input stage containing a field-effect transistor or a bipolar transistor, the sensor being at least indirectly connected to a control terminal of the field-effect transistor or of the bipolar transistor. An operating point of the amplifier circuit is set by means of a voltage or a current applied at the control terminal of the field-effect transistor or of the bipolar transistor of the input stage of the amplifier circuit.
摘要翻译： 用于记录位于测量池上的分析物的电位的测量单元。 测量单元具有传感器，布置在传感器上方并将分析物与传感器电绝缘的层，以及连接到衬底上的传感器并具有包含场效应晶体管或双极晶体管的输入级的放大器电路， 传感器至少间接连接到场效应晶体管或双极晶体管的控制端子。 放大器电路的工作点通过施加在场效应晶体管的控制端或放大器电路的输入级的双极晶体管的电压或电流来设定。
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公开(公告)号：US20060152397A1
公开(公告)日：2006-07-13
申请号：US10536764
申请日：2003-10-29
申请人： Christian Paulus
发明人： Christian Paulus
IPC分类号： H03M1/12
CPC分类号： H03M1/362
摘要： The invention relates to an analog-to-digital converter. The analog-to-digital converter, for conversion of a signal for digitization into a digital signal, contains a number of comparators, each of which has a first and second input and an output. The digitized signal is provided at said output. Each comparator is further provided with an impedance network, coupled to at least one input of the comparator, whereby an impedance network is wired between the corresponding comparator and the signal for digitization and between the corresponding comparator and a first electrical reference potential. The impedance networks are arranged such that the comparators are essentially brought to the same working point in the region of the specific decision threshold thereof.
摘要翻译： 本发明涉及一种模拟 - 数字转换器。 用于将用于数字化的信号转换为数字信号的模拟 - 数字转换器包含多个比较器，每个比较器具有第一和第二输入和输出。 在所述输出处提供数字化信号。 每个比较器进一步具有耦合到比较器的至少一个输入的阻抗网络，由此阻抗网络被布线在对应的比较器和用于数字化的信号之间以及相应的比较器和第一电参考电位之间。 阻抗网络布置成使得比较器在其特定判定阈值的区域中基本上被带到相同的工作点。
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17.发明授权Method for fabricating a microelectronic circuit including applying metal over and thickening the integrated coil to increase conductivity 有权一种制造微电子电路的方法，包括将金属涂覆在一起并增厚集成线圈以增加导电性公开(公告)号：US07005360B2
公开(公告)日：2006-02-28
申请号：US10381406
申请日：2001-10-04
IPC分类号： H01L21/20 , H01L21/4763
摘要： A method for fabricating a microelectronic circuit having an improved electrically conductive element. The method includes providing a finished processed microelectronic circuit having a monolithically integrated coil and having a passivation layer situated above at least the monolithically integrated coil. The method further comprises removing at least part of the passivation layer above the monolithically integrated coil and applying a metal layer above the monolithically integrated coil so that the metal layer is electrically coupled to the monolithically integrated coil.
摘要翻译： 一种制造具有改进的导电元件的微电子电路的方法。 该方法包括提供具有单片集成线圈并具有位于至少单片集成线圈之上的钝化层的成品处理的微电子电路。 该方法还包括去除单片集成线圈之上的钝化层的至少一部分，并且在单片集成线圈上方施加金属层，使得金属层电耦合到单片集成线圈。
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公开(公告)号：US06639456B2
公开(公告)日：2003-10-28
申请号：US10288386
申请日：2002-11-05
申请人： Christian Paulus
发明人： Christian Paulus
IPC分类号： G05F110
CPC分类号： H03F3/45183 , H03F3/265 , H03F2203/45344
摘要： A current mirror and method for operating such a mirror include nonlinearly converting an input current (Iin+=I0 and, respectively, Iin−=I0) into a voltage in a current sink, the voltage being used for driving a current source (Iout+=−n·I0 and, respectively, Iout−=n·I0) with substantially the same transfer characteristic. According to the invention, the current mirror is configured to contain a further voltage-controlled current source that supplies an auxiliary current a·Iout=−a·n·I0.
摘要翻译： 用于操作这种反射镜的电流镜和方法包括将输入电流（Iin + = I0和分别为Iin≤I0）非线性转换成电流吸收器中的电压，该电压用于驱动电流 源（Iout <+> = - n.I0，分别为Iout < - > = n.I0），具有基本上相同的传输特性。 根据本发明，电流镜被配置为包含供给辅助电流a.Iout = -a.n.I0的另外的电压控制电流源。
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公开(公告)号：US07662341B2
公开(公告)日：2010-02-16
申请号：US10530882
申请日：2003-10-14
IPC分类号： G01N33/00
CPC分类号： G01N27/4145 , G01N33/48728
摘要： A sensor arrangement and method of operating the sensor arrangement are described. The sensor arrangement has sensor devices formed on or in a substrate and a calibration device for calibrating a respective sensor device. Each sensor device has an electrical signal converter which is a field-effect transistor (FET) having a gate terminal coupled to a sensor element that is coupled to the signal converter, a device that keeps constant the electrical voltage between source and drain terminals of the FET, and a device for detecting the value of the electric current flowing through the signal converter. The sensor element characteristically influences the electrical conductivity of the signal converter on account of a sensor event on the sensor element. The calibration device brings the gate region of the FET to an electrical calibration potential such that the electric current is independent of parameter fluctuations of the FET.
摘要翻译： 描述了传感器装置和操作传感器装置的方法。 传感器装置具有形成在基板上或基板中的传感器装置和用于校准相应传感器装置的校准装置。 每个传感器装置具有电信号转换器，该电信号转换器是具有耦合到耦合到信号转换器的传感器元件的栅极端子的场效应晶体管（FET），保持恒定的源极和漏极端子之间的电压的装置 FET和用于检测流过信号转换器的电流值的装置。 传感器元件由于传感器元件上的传感器事件而特征地影响信号转换器的电导率。 校准装置使FET的栅极区域达到电校准电位，使得电流与FET的参数波动无关。
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20.发明申请Switching circuit arrangement comprising an integrated reference electrode and method for producing said switching circuit arrangement 审中-公开包括集成参考电极的开关电路装置和用于产生所述开关电路装置的方法公开(公告)号：US20060258931A1
公开(公告)日：2006-11-16
申请号：US10528504
申请日：2003-09-19
申请人： Christian Paulus
发明人： Christian Paulus
IPC分类号： A61B5/04 , G01N33/487
CPC分类号： G01N33/5438 , G01N27/3277
摘要： The invention relates to a switching circuit arrangement and a method for producing a switching circuit arrangement. Said switching circuit arrangement contains a substrate comprising an integrated switching circuit, in addition to an integrated reference electrode which is formed on the substrate and has a metal core that is at least partially surrounded by an envelope consisting of a poorly soluble salt of the metal. The integrated switching circuit is electrically coupled to the core.
摘要翻译： 本发明涉及开关电路装置及其制造方法。 所述开关电路装置包括除了集成的参考电极之外还包括集成的开关电路的基板，所述集成的参考电极形成在所述基板上并且具有至少部分地被由所述金属的难溶性盐构成的外壳包围的金属芯。 集成开关电路电耦合到芯。
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