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公开(公告)号：US07595344B2
公开(公告)日：2009-09-29
申请号：US12151296
申请日：2008-05-06
申请人： Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人： Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号： A61K31/65
CPC分类号： C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要： Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译： 公开了调节γ-分泌酶作用的唾液。 该化合物可用于治疗或预防阿尔茨海默病。
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公开(公告)号：US20090131419A1
公开(公告)日：2009-05-21
申请号：US12151296
申请日：2008-05-06
申请人： Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人： Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号： A61K31/54 , C07C317/14 , A61K31/10 , C07D295/14 , A61P25/28 , C07D241/04 , A61K31/495
CPC分类号： C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要： Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
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13.发明授权公开(公告)号：US06613765B1
公开(公告)日：2003-09-02
申请号：US09096039
申请日：1998-06-11
申请人： Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen May Seward , Christopher John Swain , Brian John Williams
发明人： Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen May Seward , Christopher John Swain , Brian John Williams
IPC分类号： A61P2524
CPC分类号： A61K31/661 , A61K31/00 , A61K31/395 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/5375 , A61K31/5377 , A61K31/675 , C07D211/56 , C07D491/10
摘要： The present invention provides methods for the treatment of major depressive disorders comprising oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such a NK-1 receptor antagonist.
摘要翻译： 本发明提供治疗重度抑郁障碍的方法，包括口服口服活性的CNS渗透性NK-1受体拮抗剂和包含这种NK-1受体拮抗剂的药物组合物。
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公开(公告)号：US6071927A
公开(公告)日：2000-06-06
申请号：US202493
申请日：1998-12-16
申请人： Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Eileen Mary Seward , Christopher John Swain , Brian John Williams
发明人： Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Eileen Mary Seward , Christopher John Swain , Brian John Williams
IPC分类号： A61K31/00 , A61K31/395 , A61K31/435 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/5375 , A61K31/5377 , A61K31/675 , A61P1/00 , A61P1/08 , A61P25/04 , A61P25/06 , A61P29/00 , A61P43/00 , C07D211/56 , C07D491/10 , C07D491/107 , C07D211/06
CPC分类号： A61K31/661 , A61K31/395 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/5375 , A61K31/5377 , A61K31/675 , C07D211/56 , C07D491/10
摘要： The present invention relates to certain spiro-piperdine derivatives which are tachykinnin antagonists and are useful, for example, in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.
摘要翻译： PCT No.PCT / GB97 / 01630 Sec。 371日期1998年12月16日第 102（e）日期1998年12月16日PCT提交1997年6月17日PCT公布。 公开号WO97 / 49710 日期1997年12月31日本发明涉及某些螺哌啶衍生物，它们是速激肽拮抗剂，可用于例如治疗或预防疼痛，炎症，偏头痛，呕吐和带状疱疹后神经痛。
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公开(公告)号：US5952315A
公开(公告)日：1999-09-14
申请号：US982053
申请日：1997-12-01
申请人： Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen Mary Seward , Christopher John Swain , Brian John Williams
发明人： Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen Mary Seward , Christopher John Swain , Brian John Williams
IPC分类号： A61K31/00 , A61K31/395 , A61K31/4015 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/675 , A61K45/00 , A61P25/24 , C07D211/56 , C07D265/32 , C07D413/06 , C07D491/10 , A61K31/44
CPC分类号： A61K31/661 , A61K31/00 , A61K31/395 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/5375 , A61K31/5377 , A61K31/675 , C07D211/56 , C07D491/10
摘要： The present invention provides methods for the treatment or prevention of bipolar disorder without concomitant therapy with other antidepressant or anti-anxiety agents which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such a NK-1 receptor antagonist.
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公开(公告)号：US07342009B2
公开(公告)日：2008-03-11
申请号：US10845833
申请日：2004-05-14
申请人： Kevin Dinnell , Timothy Harrison , Alan John Nadin , Andrew Pate Owens , Duncan Edward Shaw , Brian John Williams
发明人： Kevin Dinnell , Timothy Harrison , Alan John Nadin , Andrew Pate Owens , Duncan Edward Shaw , Brian John Williams
IPC分类号： A61K31/5415 , C07D279/02
CPC分类号： C07D279/02
摘要： Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
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公开(公告)号：US07138400B2
公开(公告)日：2006-11-21
申请号：US10415751
申请日：2001-10-29
申请人： Ian James Collins , Joanne Claire Hannam , Timothy Harrison , Stephen John Lewis , Andrew Madin , Timothy Jason Sparey , Brian John Williams
发明人： Ian James Collins , Joanne Claire Hannam , Timothy Harrison , Stephen John Lewis , Andrew Madin , Timothy Jason Sparey , Brian John Williams
IPC分类号： C07D211/18 , C07D285/10 , A61K31/435 , A61K31/433
CPC分类号： C07D249/08 , A61K31/18 , A61K31/40 , C07C307/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2603/72 , C07C2603/78 , C07D207/36 , C07D211/14 , C07D211/18 , C07D213/30 , C07D213/71 , C07D213/81 , C07D215/12 , C07D223/32 , C07D231/12 , C07D233/56 , C07D271/107 , C07D277/36 , C07D285/14 , C07D285/16 , C07D295/088 , C07D295/135 , C07D295/26 , C07D307/64 , C07D307/81 , C07D319/18 , C07D333/34 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10 , C07D513/10
摘要： Novel sulfamides of formula (I) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of Alzheimer's disease.
摘要翻译： 公开了式（I）的新型磺酰胺。 该化合物通过γ-分泌酶对APP的加工发挥抑制作用，因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号：US06271230B1
公开(公告)日：2001-08-07
申请号：US09317788
申请日：1999-05-24
申请人： Raymond Baker , Jason Matthew Elliott , Neil Roy Curtis , Timothy Harrison , Gregory John Hollingworth , Janusz Jozef Kulagowski , Philip Stephen Jackson , Nadia Melanie Rupniak , Eileen Mary Seward , Brian John Williams , Christopher John Swain
发明人： Raymond Baker , Jason Matthew Elliott , Neil Roy Curtis , Timothy Harrison , Gregory John Hollingworth , Janusz Jozef Kulagowski , Philip Stephen Jackson , Nadia Melanie Rupniak , Eileen Mary Seward , Brian John Williams , Christopher John Swain
IPC分类号： A61K31535
CPC分类号： A61K31/675 , A61K31/00 , A61K31/438 , A61K31/445 , A61K31/5375 , A61K31/5377
摘要： The present invention provides methods for the treatment or prevention of cognitive disorders which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such a NK-1 receptor antagonist.
摘要翻译： 本发明提供治疗或预防认知障碍的方法，其包括口服口服活性的CNS渗透性NK-1受体拮抗剂和包含这种NK-1受体拮抗剂的药物组合物。
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19.发明授权Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety 失效使用NK-1受体拮抗剂治疗焦虑症的重度抑郁症
公开(公告)号：US6114315A
公开(公告)日：2000-09-05
申请号：US96216
申请日：1998-06-11
申请人： Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen Mary Seward , Christopher John Swain , Brian John Williams
发明人： Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen Mary Seward , Christopher John Swain , Brian John Williams
IPC分类号： A61K31/445 , A61K31/535 , A61K21/675 , A61K21/44
CPC分类号： A61K31/5377
摘要： The present invention provides methods for the treatment or prevention of major depressive disorder with anxiety without concomitant therapy with other anti-depressant or anti-anxiety agents which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such a NK-1 receptor antagonist.
摘要翻译： 本发明提供用于治疗或预防焦虑症的重度抑郁障碍的方法，而不用与其它抗抑郁剂或抗焦虑剂并用治疗，其包括口服给药口服活性的中枢神经系统渗透性NK-1受体拮抗剂和 包含这种NK-1受体拮抗剂的药物组合物。
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公开(公告)号：US07304094B2
公开(公告)日：2007-12-04
申请号：US11261365
申请日：2005-10-28
申请人： Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams , Brian John Williams
发明人： Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams , Brian John Williams
IPC分类号： A61K31/165 , C07C321/24
CPC分类号： C07D213/40 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/27 , C07D207/404 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/56 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/72 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/44 , C07D271/06 , C07D271/10 , C07D277/26 , C07D285/12 , C07D295/096 , C07D295/185
摘要： Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译： 公式I的新型手机被公开：
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