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公开(公告)号:US07598386B2
公开(公告)日:2009-10-06
申请号:US11788888
申请日:2007-04-23
申请人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号: C07D211/00 , C07D211/68 , C07D211/40 , C07D211/70 , C07D309/00
CPC分类号: C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要: Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of γ-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.
摘要翻译: 公开了式I的新型砜:其中A完成任选包含最多两个杂原子的4-7元环。 该化合物调节γ-分泌酶的作用,因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号:US07595344B2
公开(公告)日:2009-09-29
申请号:US12151296
申请日:2008-05-06
申请人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号: A61K31/65
CPC分类号: C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要: Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译: 公开了调节γ-分泌酶作用的唾液。 该化合物可用于治疗或预防阿尔茨海默病。
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公开(公告)号:US20090131419A1
公开(公告)日:2009-05-21
申请号:US12151296
申请日:2008-05-06
申请人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号: A61K31/54 , C07C317/14 , A61K31/10 , C07D295/14 , A61P25/28 , C07D241/04 , A61K31/495
CPC分类号: C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要: Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
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公开(公告)号:US07105509B2
公开(公告)日:2006-09-12
申请号:US10296428
申请日:2001-05-21
申请人: Jose Luis Castro Pineiro , Ian Churcher , Alexander Richard Guiblin , Timothy Harrison , Sonia Kerrard , Andrew Madin , Alan John Nadin , Andrew Pate Owens , Timothy Jason Sparey , Martin Richard Teall , Susannah Williams
发明人: Jose Luis Castro Pineiro , Ian Churcher , Alexander Richard Guiblin , Timothy Harrison , Sonia Kerrard , Andrew Madin , Alan John Nadin , Andrew Pate Owens , Timothy Jason Sparey , Martin Richard Teall , Susannah Williams
IPC分类号: C07D243/24 , C07D243/12 , C07D417/04 , A61K31/55 , A61P25/28
CPC分类号: C07D401/04 , A61K31/55 , C07D243/14 , C07D243/24 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D417/06 , C07D417/12 , C07D487/04 , C07D491/10
摘要: A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by γ-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of β-amyloid, such as Alzheimer's disease
摘要翻译: 公开了一类新颖的式(I)的1,4-和1,5-苯并二氮杂。 该化合物通过γ-分泌酶调节淀粉样前体蛋白的加工,因此可用于治疗或预防与β-淀粉样蛋白沉积相关的病症,例如阿尔茨海默病
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公开(公告)号:US07410964B2
公开(公告)日:2008-08-12
申请号:US10555034
申请日:2004-05-07
申请人: Kevin Dinnell , Karl Richard Gibson , Timothy Harrison , Richard Alexander Jelley , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Brian John Williams
发明人: Kevin Dinnell , Karl Richard Gibson , Timothy Harrison , Richard Alexander Jelley , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Brian John Williams
IPC分类号: C07D285/22 , A61K31/5415
CPC分类号: C07D279/02
摘要: Compounds of formula I: inhibit gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease.
摘要翻译: 式I化合物:抑制γ-分泌酶,因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号:US06890956B2
公开(公告)日:2005-05-10
申请号:US10679902
申请日:2003-10-06
申请人: Ian Churcher , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Andrew Pate Owens , Duncan Edward Shaw , Joanne Thomson , Susannah Williams
发明人: Ian Churcher , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Andrew Pate Owens , Duncan Edward Shaw , Joanne Thomson , Susannah Williams
IPC分类号: A61K31/10 , A61P25/28 , C07C317/30 , C07D213/70 , C07D213/74 , C07D231/18 , C07D233/42 , C07D249/12 , C07D257/04 , C07D261/10 , C07D275/02 , C07D275/03 , C07D277/36 , C07D295/088 , C07D307/64 , C07D333/34 , A61K31/18 , C07C323/23
CPC分类号: C07D213/70 , A61K31/10 , C07C317/30 , C07C2601/14 , C07D213/74 , C07D231/18 , C07D233/42 , C07D249/12 , C07D257/04 , C07D261/10 , C07D275/03 , C07D277/36 , C07D295/088 , C07D307/64 , C07D333/34
摘要: Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
摘要翻译: 式I化合物:通过γ-分泌酶抑制APP的加工,因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号:US07342009B2
公开(公告)日:2008-03-11
申请号:US10845833
申请日:2004-05-14
申请人: Kevin Dinnell , Timothy Harrison , Alan John Nadin , Andrew Pate Owens , Duncan Edward Shaw , Brian John Williams
发明人: Kevin Dinnell , Timothy Harrison , Alan John Nadin , Andrew Pate Owens , Duncan Edward Shaw , Brian John Williams
IPC分类号: A61K31/5415 , C07D279/02
CPC分类号: C07D279/02
摘要: Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
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公开(公告)号:US07655675B2
公开(公告)日:2010-02-02
申请号:US10957251
申请日:2004-10-01
IPC分类号: A61K31/40 , A61K31/44 , C07D207/48 , C07D211/96
CPC分类号: C07C311/14 , C07C2601/14 , C07D207/48 , C07D211/96 , C07D409/12
摘要: Compounds of formula I: inhibit the processing of APP by gamma-secretase and hence find use in treatment of Alzheimer's disease.
摘要翻译: 式I化合物:通过γ-分泌酶抑制APP的加工,因此可用于治疗阿尔茨海默氏病。
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公开(公告)号:US06995155B2
公开(公告)日:2006-02-07
申请号:US10399231
申请日:2001-08-08
申请人: Ian Churcher , Alan John Nadin , Andrew Pate Owens
发明人: Ian Churcher , Alan John Nadin , Andrew Pate Owens
IPC分类号: C07D243/24 , C07D403/04 , A61K31/5513 , A61P25/28
CPC分类号: C07D401/04 , C07D243/24 , C07D403/04
摘要: Compounds of formula (I) are disclosed. The compounds inhibit the action of gamma secretase, and hence find use in the treatment and prevention of Alzheimer's disease.
摘要翻译: 公开了式(I)的化合物。 该化合物抑制γ-分泌酶的作用,因此可用于治疗和预防阿尔茨海默病。
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公开(公告)号:US06872731B2
公开(公告)日:2005-03-29
申请号:US10155691
申请日:2002-05-23
申请人: James Michael Crawforth , Simon Charles Goodacre , Timothy Harrison , David James Hallett , Andrew Pate Owens , Michael Rowley , Martin Richard Teall
发明人: James Michael Crawforth , Simon Charles Goodacre , Timothy Harrison , David James Hallett , Andrew Pate Owens , Michael Rowley , Martin Richard Teall
IPC分类号: A61K31/437 , A61K31/444 , A61P1/08 , A61P3/04 , A61P15/00 , A61P21/00 , A61P23/00 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/24 , A61P27/16 , A61P43/00 , C07B61/00 , C07D471/04 , A61K31/435
CPC分类号: C07D471/04
摘要: A class of 3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH-linkage, are selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
摘要翻译: 一类3-苯基咪唑并[1,2-a]吡啶衍生物,其在苯环的间位被被氧原子或-NH-键直接连接或桥连的任选取代的芳基或杂芳基取代, 是GABA A受体的选择性配体,特别是对其α2和/或α3亚基具有高亲和力,因此有益于治疗和/或预防中枢神经系统疾病,包括焦虑和抽搐。
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