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185 条记录 (耗时 0.072 秒)

    NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS
    11.
    发明申请
    NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS 审中-公开
    新型半合成糖苷作为抗菌剂

    公开(公告)号：US20120252741A1

    公开(公告)日：2012-10-04

    申请号：US13440692

    申请日：2012-04-05

    申请人： Daniel Chu ,  Tao Ye ,  Bing Wang

    发明人： Daniel Chu ,  Tao Ye ,  Bing Wang

    IPC分类号： A61K38/14 ,  A61P31/04 ,  C07K1/06 ,  C07K9/00

    CPC分类号： C07K9/006

    摘要： Provided herein are semi-synthetic glycopeptides having antibacterial activity. The semi-synthetic glycopeptides described herein are made by chemical modification of a glycopeptide by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety with certain acyl groups; conversion of the amide group in amino acid-3 to various acylamide, acylsulfonamide, acylsulfonylurea derivatives; aminomethylation with substituent containing sulfonamide or acylsulfonamide group on amino acid-7 through Mannich reaction; and conversion of the acid moiety on the macrocyclic ring to certain substituted amides. Also provided herein are pharmaceutical compositions comprising the semi-synthetic glycopeptides, and methods of use of the semi-synthetic glycopeptides for the treatment and/or prophylaxis of diseases, especially bacterial infections.

    摘要翻译： 本文提供具有抗菌活性的半合成糖肽。 本文所述的半合成糖肽通过在酸性介质中水解母体糖肽的氨基酸-4的二糖部分而使糖肽进行化学修饰来制备，得到氨基酸-4单糖; 单糖转化为氨基糖衍生物; 用某些酰基酰化氨基酸4氨基取代的糖部分上的氨基取代基; 氨基酸-3中的酰胺基转化为各种酰基酰胺，酰基磺酰胺，酰基磺酰脲衍生物; 通过曼尼希反应在氨基酸-7上氨基甲基化与含有磺酰胺或酰基磺酰胺基团的取代基; 并将大环上的酸部分转化为某些取代的酰胺。 本文还提供了包含半合成糖肽的药物组合物，以及使用半合成糖肽来治疗和/或预防疾病，特别是细菌感染的方法。

    Monitoring server load balancing
    12.
    发明授权
    Monitoring server load balancing 有权
    监控服务器负载均衡

    公开(公告)号：US08248928B1

    公开(公告)日：2012-08-21

    申请号：US11937285

    申请日：2007-11-08

    申请人： Bing Wang ,  David Cheung

    发明人： Bing Wang ,  David Cheung

    IPC分类号： G01R31/08

    CPC分类号： H04L43/0894 ,  H04L43/026 ,  H04L43/12 ,  H04L47/125 ,  H04L63/1408 ,  H04L67/1014

    摘要： Embodiments described herein discuss an approach to implementing load-balancing across multiple monitoring servers. One such embodiment describes a network monitoring device. The network monitoring device includes an ingress port, for receiving mirrored network packets, and a number of egress ports. The egress ports are associated with a number of monitoring servers, and used to forward the mirrored network packets to the monitoring servers. A packet classifier, coupled to the ingress port, examines the mirrored network packets, and determines which of the monitoring servers should receive the packets.

    摘要翻译： 本文描述的实施例讨论了跨多个监控服务器实现负载平衡的方法。 一个这样的实施例描述了网络监视设备。 网络监控设备包括入口端口，用于接收镜像网络报文，以及多个出口端口。 出口端口与多个监控服务器相关联，用于将镜像网络数据包转发到监控服务器。 耦合到入口端口的数据包分类器检查镜像网络数据包，并确定哪些监视服务器应该接收数据包。

    Method and apparatus for full clock cycle charge pump operation
    13.
    发明授权
    Method and apparatus for full clock cycle charge pump operation 有权
    全时钟周期电荷泵运行的方法和装置

    公开(公告)号：US08248153B2

    公开(公告)日：2012-08-21

    申请号：US12825423

    申请日：2010-06-29

    申请人： Ming-Chieh Huang ,  Bing Wang

    发明人： Ming-Chieh Huang ,  Bing Wang

    IPC分类号： G05F1/10

    CPC分类号： H02M3/073 ,  G11C5/145 ,  H02M2001/0003 ,  H02M2003/075

    摘要： A charge pump comprises at least one charge pump cell and control logic. The at least one charge pump cell is configured to receive a power supply voltage and provide a pump output voltage higher than the power supply voltage. The control logic is configured to receive an oscillator signal and a level detector enable signal, provide at least one cell clock signal, based on the oscillator signal, to the at least one charge pump cell, control the at least one pump cell to charge while the level detector enable signal is asserted, and control the at least one pump cell to continue to charge after the level detector enable signal is deasserted and until a full pulse cycle of the oscillator signal is completed.

    摘要翻译： 电荷泵包括至少一个电荷泵电池和控制逻辑。 所述至少一个电荷泵单元被配置为接收电源电压并提供高于所述电源电压的泵输出电压。 控制逻辑被配置为接收振荡器信号和电平检测器使能信号，基于振荡器信号将至少一个单元时钟信号提供给至少一个电荷泵单元，控制至少一个泵浦单元进行充电，同时 电平检测器使能信号被断言，并且在电平检测器使能信号被断言并且直到振荡器信号的完整脉冲周期完成之后，控制至少一个泵浦单元继续充电。

    Docking Pose Selection Optimization via NMR Chemical Shift Perturbation Analysis
    19.
    发明申请
    Docking Pose Selection Optimization via NMR Chemical Shift Perturbation Analysis 审中-公开
    通过NMR化学位移扰动分析对接姿势选择优化

    公开(公告)号：US20100250217A1

    公开(公告)日：2010-09-30

    申请号：US12675503

    申请日：2008-08-28

    申请人： Bing Wang ,  Kenneth Malcom Merz, JR.

    发明人： Bing Wang ,  Kenneth Malcom Merz, JR.

    IPC分类号： G06G7/48

    CPC分类号： G16C20/60 ,  G01N2500/04 ,  G16B15/00 ,  G16B35/00

    摘要： Using NMRScore to generate an RMSD and evaluating whether the RMSD is below 1 ppm, in order to indicate that a docking software generated pose is a good match with the experimental assessment of a paradigm protein target and paradigm ligand, and therefore that the pose will be useful and accurate for the same target and similar ligands, or similar targets and the same ligands.

    摘要翻译： 使用NMRScore产生RMSD并评估RMSD是否低于1 ppm，以表明对接软件生成姿势与范式蛋白质靶标和范式配体的实验评估很好匹配，因此姿势将是 对于相同的靶和类似的配体或相似的靶标和相同的配体是有用和准确的。