-
公开(公告)号：US20100202989A1
公开(公告)日：2010-08-12
申请号：US12762497
申请日：2010-04-19
申请人： Bing Wang , Sekhar Bodupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
发明人： Bing Wang , Sekhar Bodupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
CPC分类号： A61K45/06 , A61K8/44 , A61K8/49 , A61K8/498 , A61K31/135 , A61K31/195 , A61K31/40 , A61K31/44 , A61K31/66 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.
摘要翻译： 公开了一种减少与包含本文所述的包含本文所述的任何式I或Ia的化合物的局部组合物在眼睛下的皮肤紧致性，皮肤紧致度或黑眼圈丧失相关的皮肤状况的外观的方法。
-
公开(公告)号：US07737179B2
公开(公告)日：2010-06-15
申请号：US10910095
申请日：2004-08-02
申请人： Bing Wang , Sekhar Bodupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
发明人： Bing Wang , Sekhar Bodupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
IPC分类号： A01N37/44
CPC分类号： A61K45/06 , A61K8/44 , A61K8/49 , A61K8/498 , A61K31/135 , A61K31/195 , A61K31/40 , A61K31/44 , A61K31/66 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.
摘要翻译： 公开了一种减少与包含本文所述的包含本文所述的任何式I或Ia的化合物的局部组合物在眼睛下的皮肤紧致性，皮肤紧致度或黑眼圈丧失相关的皮肤状况的外观的方法。
-
公开(公告)号：US20050032751A1
公开(公告)日：2005-02-10
申请号：US10910095
申请日：2004-08-02
申请人： Bing Wang , Sekhar Boddupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
发明人： Bing Wang , Sekhar Boddupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
IPC分类号： A61K8/44 , A61K8/49 , A61K31/135 , A61K31/195 , A61K31/40 , A61K31/44 , A61K31/66 , A61K45/06 , A61Q19/00 , A61Q19/08
CPC分类号： A61K45/06 , A61K8/44 , A61K8/49 , A61K8/498 , A61K31/135 , A61K31/195 , A61K31/40 , A61K31/44 , A61K31/66 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.
摘要翻译： 公开了一种减少与包含本文所述的包含本文所述的任何式I或Ia的化合物的局部组合物在眼睛下的皮肤紧致性，皮肤紧致度或黑眼圈丧失相关的皮肤状况的外观的方法。
-
公开(公告)号：US20050065099A1
公开(公告)日：2005-03-24
申请号：US10941126
申请日：2004-09-15
申请人： Gail Walkinshaw , Sekhar Bodupalli , Bing Wang , Guy Miller
发明人： Gail Walkinshaw , Sekhar Bodupalli , Bing Wang , Guy Miller
IPC分类号： A61K31/353 , A61K31/675 , A61K31/7048 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357 , A61K31/496 , A61K31/675 , A61K31/7048 , C07D295/096 , C07D311/58 , C07D311/70 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
摘要： The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Myoclonic Epilepsy with Ragged Red Fibers (MERFF), amyotrophic lateral sclerosis (ALS), motor neuron diseases, Huntington's disease, macular degeneration, and epilepsy, with chroman derivatives of Formula I or Formula II as described herein.
摘要翻译： 本发明涉及线粒体疾病如阿尔茨海默病，帕金森病，弗里德里希共济失调（FRDA），小脑共济失调，莱伯氏遗传性视神经病变（LHON），线粒体肌病，脑病，乳酸酸中毒，中风（MELAS），肌阵挛 具有褴褛红色纤维（MERFF）的癫痫，肌萎缩性侧索硬化（ALS），运动神经元疾病，亨廷顿氏病，黄斑变性和癫痫，与本文所述的式I或式II的苯并二氢吡喃衍生物。
-
公开(公告)号：US20060178356A1
公开(公告)日：2006-08-10
申请号：US11387507
申请日：2006-03-22
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07F1/08 , A61K31/555 , A61K31/426 , A61K31/4152 , A61K31/444
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
-
6.发明授权Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods 有权细胞保护化合物，药物和化妆品制剂及方法公开(公告)号：US07629375B2
公开(公告)日：2009-12-08
申请号：US11015198
申请日：2004-12-16
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： A61K31/415 , A01N43/56
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
摘要翻译： 细胞保护性化合物，其中许多是以具有某些缀合键的取代苯酚为特征的酚类衍生物，可用于治疗某些缺血性或炎症性疾病，包括但不限于中风，心肌梗死，充血性心力衰竭和特征为 炎症或氧化损伤。 它们也可用于制造用于治疗这些病症的药物和化妆品制剂。
-
公开(公告)号：US20050113416A1
公开(公告)日：2005-05-26
申请号：US11015198
申请日：2004-12-16
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07D295/18 , A61K8/00 , A61K8/30 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/122 , A61K31/15 , A61K31/166 , A61K31/18 , A61K31/192 , A61K31/21 , A61K31/235 , A61K31/277 , A61K31/28 , A61K31/30 , A61K31/315 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4425 , A61K31/444 , A61K31/4453 , A61K31/5375 , A61K31/555 , A61K31/662 , A61K31/7024 , A61K33/32 , A61P1/04 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/16 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/06 , A61P43/00 , A61Q19/00 , A61Q19/02 , C07C39/21 , C07C39/373 , C07C39/44 , C07C43/215 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C49/747 , C07C50/34 , C07C69/007 , C07C69/76 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/15 , C07C255/36 , C07C255/53 , C07C255/54 , C07C311/29 , C07C317/22 , C07D213/30 , C07D213/53 , C07D231/22 , C07D231/26 , C07D233/24 , C07D233/64 , C07D235/08 , C07D277/20 , C07D277/24 , C07D277/30 , C07D277/34 , C07D295/22 , C07D295/26 , C07D307/83 , C07D311/72 , C07D317/62 , C07D333/16 , C07F1/08 , C07F9/40 , C07H13/08 , A61K31/445 , A61K31/165 , A61K31/185 , A61K31/40
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
-
公开(公告)号：US06916850B2
公开(公告)日：2005-07-12
申请号：US10138937
申请日：2002-05-03
申请人： Bing Wang , Guy Miller , Wei Zhang
发明人： Bing Wang , Guy Miller , Wei Zhang
IPC分类号： A61K31/12 , A61K31/16 , A61K31/215 , A61K31/223 , A61K38/00 , A61P9/10 , C07C249/12 , C07C251/60 , C07C319/20 , C07C323/57 , C07C323/60 , C07D207/16 , C07D207/22 , C07D207/24 , C07D211/62 , C07D211/74 , C07D211/78 , C07D213/30 , C07D217/04 , C07D233/42 , C07D233/54 , C07D233/84 , C07D235/28 , C07D239/78 , C07D249/14 , C07D271/10 , C07D271/113 , C07D277/16 , C07D277/74 , C07D279/12 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/13 , C07D295/15 , C07D295/185 , C07D339/08 , C07D345/00 , C07D405/12 , C07D473/38 , C07K5/02 , C07K5/093 , C07C317/04 , A61K31/10 , C07C321/14
CPC分类号： C07D213/30 , A61K31/12 , A61K31/16 , A61K31/215 , A61K31/223 , A61K38/00 , C07C249/12 , C07C319/20 , C07C323/60 , C07D207/16 , C07D207/22 , C07D207/24 , C07D211/62 , C07D211/74 , C07D211/78 , C07D217/04 , C07D233/42 , C07D233/64 , C07D233/84 , C07D235/28 , C07D239/78 , C07D249/14 , C07D271/113 , C07D277/16 , C07D277/74 , C07D279/12 , C07D285/125 , C07D285/135 , C07D295/13 , C07D295/15 , C07D295/185 , C07D339/08 , C07D345/00 , C07D405/12 , C07D473/38 , C07K5/0215 , C07K5/0819 , C07C323/57 , C07C251/60
摘要： Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e.g., polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.
-
9.发明申请Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods 审中-公开细胞保护化合物，药物和化妆品制剂及方法公开(公告)号：US20050142155A1
公开(公告)日：2005-06-30
申请号：US11055895
申请日：2005-02-10
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07D295/18 , A61K8/00 , A61K8/30 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/122 , A61K31/15 , A61K31/166 , A61K31/18 , A61K31/192 , A61K31/21 , A61K31/235 , A61K31/277 , A61K31/28 , A61K31/30 , A61K31/315 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4425 , A61K31/444 , A61K31/4453 , A61K31/5375 , A61K31/555 , A61K31/662 , A61K31/7024 , A61K33/32 , A61P1/04 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/16 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/06 , A61P43/00 , A61Q19/00 , A61Q19/02 , C07C39/21 , C07C39/373 , C07C39/44 , C07C43/215 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C49/747 , C07C50/34 , C07C69/007 , C07C69/76 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/15 , C07C255/36 , C07C255/53 , C07C255/54 , C07C311/29 , C07C317/22 , C07D213/30 , C07D213/53 , C07D231/22 , C07D231/26 , C07D233/24 , C07D233/64 , C07D235/08 , C07D277/20 , C07D277/24 , C07D277/30 , C07D277/34 , C07D295/22 , C07D295/26 , C07D307/83 , C07D311/72 , C07D317/62 , C07D333/16 , C07F1/08 , C07F9/40 , C07H13/08 , A61K7/42 , A61K31/4152 , A61K31/42 , C07D231/08 , C07D261/12
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
摘要翻译： 细胞保护性化合物，其中许多是以具有某些缀合键的取代苯酚为特征的酚类衍生物，可用于治疗某些缺血性或炎症性疾病，包括但不限于中风，心肌梗死，充血性心力衰竭和特征为 炎症或氧化损伤。 它们也可用于制造用于治疗这些病症的药物和化妆品制剂。
-
10.发明授权公开(公告)号：US07034054B2
公开(公告)日：2006-04-25
申请号：US10020450
申请日：2001-12-14
申请人： Guy Miller , Lesley A. Brown , Ughetta Del Balzo , Stephen Flaim , Sekhar Boddupalli , Bing Wang
发明人： Guy Miller , Lesley A. Brown , Ughetta Del Balzo , Stephen Flaim , Sekhar Boddupalli , Bing Wang
IPC分类号： A61K31/355
CPC分类号： A61K31/355 , A23L33/105 , A23V2002/00 , A23V2250/2116 , A23V2250/712
摘要： The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions.
摘要翻译： 本发明提供了治疗与脑缺血相关的神经元损伤的症状的方法，包括给予富含γ-，β-或δ-生育酚的生育酚组合物。
-
-
-
-
-
-
-
-
-
搜索结果
185 条记录 (耗时 0.04 秒)
