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公开(公告)号：US20100202989A1
公开(公告)日：2010-08-12
申请号：US12762497
申请日：2010-04-19
申请人： Bing Wang , Sekhar Bodupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
发明人： Bing Wang , Sekhar Bodupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
CPC分类号： A61K45/06 , A61K8/44 , A61K8/49 , A61K8/498 , A61K31/135 , A61K31/195 , A61K31/40 , A61K31/44 , A61K31/66 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.
摘要翻译： 公开了一种减少与包含本文所述的包含本文所述的任何式I或Ia的化合物的局部组合物在眼睛下的皮肤紧致性，皮肤紧致度或黑眼圈丧失相关的皮肤状况的外观的方法。
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公开(公告)号：US07737179B2
公开(公告)日：2010-06-15
申请号：US10910095
申请日：2004-08-02
申请人： Bing Wang , Sekhar Bodupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
发明人： Bing Wang , Sekhar Bodupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
IPC分类号： A01N37/44
CPC分类号： A61K45/06 , A61K8/44 , A61K8/49 , A61K8/498 , A61K31/135 , A61K31/195 , A61K31/40 , A61K31/44 , A61K31/66 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.
摘要翻译： 公开了一种减少与包含本文所述的包含本文所述的任何式I或Ia的化合物的局部组合物在眼睛下的皮肤紧致性，皮肤紧致度或黑眼圈丧失相关的皮肤状况的外观的方法。
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公开(公告)号：US20050032751A1
公开(公告)日：2005-02-10
申请号：US10910095
申请日：2004-08-02
申请人： Bing Wang , Sekhar Boddupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
发明人： Bing Wang , Sekhar Boddupalli , Xiangfeng Li , Khalid Mahmood , Wei Zhang , Guy Miller
IPC分类号： A61K8/44 , A61K8/49 , A61K31/135 , A61K31/195 , A61K31/40 , A61K31/44 , A61K31/66 , A61K45/06 , A61Q19/00 , A61Q19/08
CPC分类号： A61K45/06 , A61K8/44 , A61K8/49 , A61K8/498 , A61K31/135 , A61K31/195 , A61K31/40 , A61K31/44 , A61K31/66 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.
摘要翻译： 公开了一种减少与包含本文所述的包含本文所述的任何式I或Ia的化合物的局部组合物在眼睛下的皮肤紧致性，皮肤紧致度或黑眼圈丧失相关的皮肤状况的外观的方法。
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4.发明授权Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods 有权细胞保护化合物，药物和化妆品制剂及方法公开(公告)号：US07629375B2
公开(公告)日：2009-12-08
申请号：US11015198
申请日：2004-12-16
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： A61K31/415 , A01N43/56
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
摘要翻译： 细胞保护性化合物，其中许多是以具有某些缀合键的取代苯酚为特征的酚类衍生物，可用于治疗某些缺血性或炎症性疾病，包括但不限于中风，心肌梗死，充血性心力衰竭和特征为 炎症或氧化损伤。 它们也可用于制造用于治疗这些病症的药物和化妆品制剂。
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公开(公告)号：US20050113416A1
公开(公告)日：2005-05-26
申请号：US11015198
申请日：2004-12-16
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07D295/18 , A61K8/00 , A61K8/30 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/122 , A61K31/15 , A61K31/166 , A61K31/18 , A61K31/192 , A61K31/21 , A61K31/235 , A61K31/277 , A61K31/28 , A61K31/30 , A61K31/315 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4425 , A61K31/444 , A61K31/4453 , A61K31/5375 , A61K31/555 , A61K31/662 , A61K31/7024 , A61K33/32 , A61P1/04 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/16 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/06 , A61P43/00 , A61Q19/00 , A61Q19/02 , C07C39/21 , C07C39/373 , C07C39/44 , C07C43/215 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C49/747 , C07C50/34 , C07C69/007 , C07C69/76 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/15 , C07C255/36 , C07C255/53 , C07C255/54 , C07C311/29 , C07C317/22 , C07D213/30 , C07D213/53 , C07D231/22 , C07D231/26 , C07D233/24 , C07D233/64 , C07D235/08 , C07D277/20 , C07D277/24 , C07D277/30 , C07D277/34 , C07D295/22 , C07D295/26 , C07D307/83 , C07D311/72 , C07D317/62 , C07D333/16 , C07F1/08 , C07F9/40 , C07H13/08 , A61K31/445 , A61K31/165 , A61K31/185 , A61K31/40
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
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公开(公告)号：US20060178356A1
公开(公告)日：2006-08-10
申请号：US11387507
申请日：2006-03-22
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07F1/08 , A61K31/555 , A61K31/426 , A61K31/4152 , A61K31/444
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
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公开(公告)号：US06916850B2
公开(公告)日：2005-07-12
申请号：US10138937
申请日：2002-05-03
申请人： Bing Wang , Guy Miller , Wei Zhang
发明人： Bing Wang , Guy Miller , Wei Zhang
IPC分类号： A61K31/12 , A61K31/16 , A61K31/215 , A61K31/223 , A61K38/00 , A61P9/10 , C07C249/12 , C07C251/60 , C07C319/20 , C07C323/57 , C07C323/60 , C07D207/16 , C07D207/22 , C07D207/24 , C07D211/62 , C07D211/74 , C07D211/78 , C07D213/30 , C07D217/04 , C07D233/42 , C07D233/54 , C07D233/84 , C07D235/28 , C07D239/78 , C07D249/14 , C07D271/10 , C07D271/113 , C07D277/16 , C07D277/74 , C07D279/12 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/13 , C07D295/15 , C07D295/185 , C07D339/08 , C07D345/00 , C07D405/12 , C07D473/38 , C07K5/02 , C07K5/093 , C07C317/04 , A61K31/10 , C07C321/14
CPC分类号： C07D213/30 , A61K31/12 , A61K31/16 , A61K31/215 , A61K31/223 , A61K38/00 , C07C249/12 , C07C319/20 , C07C323/60 , C07D207/16 , C07D207/22 , C07D207/24 , C07D211/62 , C07D211/74 , C07D211/78 , C07D217/04 , C07D233/42 , C07D233/64 , C07D233/84 , C07D235/28 , C07D239/78 , C07D249/14 , C07D271/113 , C07D277/16 , C07D277/74 , C07D279/12 , C07D285/125 , C07D285/135 , C07D295/13 , C07D295/15 , C07D295/185 , C07D339/08 , C07D345/00 , C07D405/12 , C07D473/38 , C07K5/0215 , C07K5/0819 , C07C323/57 , C07C251/60
摘要： Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e.g., polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.
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8.发明申请Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods 审中-公开细胞保护化合物，药物和化妆品制剂及方法公开(公告)号：US20050142155A1
公开(公告)日：2005-06-30
申请号：US11055895
申请日：2005-02-10
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07D295/18 , A61K8/00 , A61K8/30 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/122 , A61K31/15 , A61K31/166 , A61K31/18 , A61K31/192 , A61K31/21 , A61K31/235 , A61K31/277 , A61K31/28 , A61K31/30 , A61K31/315 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4425 , A61K31/444 , A61K31/4453 , A61K31/5375 , A61K31/555 , A61K31/662 , A61K31/7024 , A61K33/32 , A61P1/04 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/16 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/06 , A61P43/00 , A61Q19/00 , A61Q19/02 , C07C39/21 , C07C39/373 , C07C39/44 , C07C43/215 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C49/747 , C07C50/34 , C07C69/007 , C07C69/76 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/15 , C07C255/36 , C07C255/53 , C07C255/54 , C07C311/29 , C07C317/22 , C07D213/30 , C07D213/53 , C07D231/22 , C07D231/26 , C07D233/24 , C07D233/64 , C07D235/08 , C07D277/20 , C07D277/24 , C07D277/30 , C07D277/34 , C07D295/22 , C07D295/26 , C07D307/83 , C07D311/72 , C07D317/62 , C07D333/16 , C07F1/08 , C07F9/40 , C07H13/08 , A61K7/42 , A61K31/4152 , A61K31/42 , C07D231/08 , C07D261/12
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
摘要翻译： 细胞保护性化合物，其中许多是以具有某些缀合键的取代苯酚为特征的酚类衍生物，可用于治疗某些缺血性或炎症性疾病，包括但不限于中风，心肌梗死，充血性心力衰竭和特征为 炎症或氧化损伤。 它们也可用于制造用于治疗这些病症的药物和化妆品制剂。
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9.发明授权Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry 有权使用点击化学开发碳酸酐酶IX的分子成像探针公开(公告)号：US07829063B2
公开(公告)日：2010-11-09
申请号：US12099135
申请日：2008-04-07
申请人： Hartmuth C. Kolb , Joseph C. Walsh , Dhanalakshmi Kasi , Vani P. Mocharla , Bing Wang , Umesh B. Gangadharmath , Brian A. Duclos , Kai Chen , Wei Zhang , Gang Chen , Henry Clifton Padgett , Farhad Karimi , Peter J. H. Scott , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Tieming Zhao , Chunfang Xia
发明人： Hartmuth C. Kolb , Joseph C. Walsh , Dhanalakshmi Kasi , Vani P. Mocharla , Bing Wang , Umesh B. Gangadharmath , Brian A. Duclos , Kai Chen , Wei Zhang , Gang Chen , Henry Clifton Padgett , Farhad Karimi , Peter J. H. Scott , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Tieming Zhao , Chunfang Xia
IPC分类号： A61K51/00 , C07D343/00
CPC分类号： C07D417/04 , C07D249/04 , C07D249/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14 , C12Q1/485 , G01N2500/04 , G01N2500/10
摘要： The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
摘要翻译： 本申请公开了使用点击化学法鉴定对碳酸酐酶IX（CA-IX）酶具有高结合亲和力的抑制剂的方法，并将其候选用作正电子发射断层摄影（PET）成像剂。
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公开(公告)号：US07514461B2
公开(公告)日：2009-04-07
申请号：US10941125
申请日：2004-09-15
申请人： Bing Wang , Gail Walkinshaw , Sekhar Boddupalli , Arkadij M. Elizarov , Xianming Jin , Xianfeng Li , Donald R. James , Jiangao Song , Jian Chen , Wei Zhang
发明人： Bing Wang , Gail Walkinshaw , Sekhar Boddupalli , Arkadij M. Elizarov , Xianming Jin , Xianfeng Li , Donald R. James , Jiangao Song , Jian Chen , Wei Zhang
IPC分类号： A61K31/355 , A61K31/427 , A61K31/4152 , C07D311/72 , C07D405/06 , C07D417/06
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357 , A61K31/496 , A61K31/675 , A61K31/7048 , C07D295/096 , C07D311/58 , C07D311/70 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
摘要： The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
摘要翻译： 本发明涉及式I的新型色满衍生物，立体异构体和药学上可接受的盐，其中取代基如说明书中所定义。 它们可用于治疗由脂氧合酶介导的疾病，例如免疫疾病，呼吸系统疾病和心血管疾病，以及治疗神经变性疾病和/或线粒体疾病。 它们也可用于制备用于治疗这些病症的药物制剂。
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