公开(公告)号：US20210169083A1

公开(公告)日：2021-06-10

申请号：US17110389

申请日：2020-12-03

Applicant: CORNING INCORPORATED

Inventor： David Henry ,  Valerie Claudine Lacarriere

IPC: A01N57/16 ,  C12N15/113 ,  A01N25/04

Abstract: A stable aqueous suspension includes a composition which includes nanoparticles, wherein said nanoparticles include a nucleic acid at least partially encapsulated in a matrix comprising calcium phosphate. The nanoparticle compositions and suspensions have high nucleic acid loading and high stability, and may be used for protecting crops against insects and for down-regulating expression of a target gene in an insect pest species in order to prevent and/or control pest infestation.

公开(公告)号：US10941312B2

公开(公告)日：2021-03-09

申请号：US16196516

申请日：2018-11-20

Applicant: Corning Incorporated

Inventor： Anthony Glenn Frutos ,  David Henry ,  Corinne Walerack

IPC: C09D151/00 ,  C09D189/00 ,  B05D3/06 ,  C08F220/20 ,  C08F220/28

Abstract: A method for coating a surface of a cell culture article includes dissolving a polymer having a covalently attached polypeptide in an aqueous solution to produce a polymer solution. The polymer is formed from monomers selected to form a polymer having a linear backbone, wherein the polymer is crosslink free. The weight percentage of the polypeptide relative to the polymer conjugated to the polypeptide is sufficiently high to render the polymer conjugated to the polypeptide water soluble. The aqueous solution is substantially free of organic solvents. The method further includes (i) disposing the polymer solution on the surface of the cell culture article to produce a coated article; and (ii) subjecting the coated article to sufficient heat or electromagnetic radiation to attach the polymer conjugated to a polypeptide to the surface of the cell culture article.

公开(公告)号：US10808221B2

公开(公告)日：2020-10-20

申请号：US15537111

申请日：2015-12-16

Applicant: Corning Incorporated

Inventor： Ye Fang ,  Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral ,  David Henry ,  Martial Hervy ,  Corinne Walerack ,  Yue Zhou

IPC: C12N5/00 ,  C08J3/24 ,  C09D167/00

Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.

公开(公告)号：US20170340527A1

公开(公告)日：2017-11-30

申请号：US15603098

申请日：2017-05-23

Applicant: Corning Incorporated

Inventor： Theresa Chang ,  Ye Fang ,  David Henry ,  Wendell Porter Weeks ,  Ying Wei

IPC: A61K8/11 ,  A61K8/19 ,  A61K8/73 ,  A61Q19/10 ,  A61K8/25 ,  A61K8/26

CPC classification number: A61K8/11 ,  A61K8/0241 ,  A61K8/19 ,  A61K8/25 ,  A61K8/26 ,  A61K8/73 ,  A61K8/733 ,  A61K2800/28 ,  A61K2800/412 ,  A61K2800/413 ,  A61K2800/624 ,  A61K2800/651 ,  A61Q19/10

Abstract: An exfoliant composition including: a microbead comprising a core and a shell: the core comprising an abrasive particle having an average particle size of from 50 to 1,000 microns; and the shell comprising a hydrogel. Also disclosed is a method of making the exfoliant composition and a method of using the exfoliant composition.

公开(公告)号：US20140161980A1

公开(公告)日：2014-06-12

申请号：US14095217

申请日：2013-12-03

Applicant: CORNING INCORPORATED

Inventor： Melissa Danielle Cremer ,  Shandon Dee Hart ,  David Henry ,  Shawn Michael O'Malley ,  Vitor Marino Schneider

IPC: C09D1/00

CPC classification number: C09D1/00 ,  C03C17/25 ,  C03C17/253 ,  C03C17/256 ,  C03C17/3417 ,  C03C21/002 ,  C03C2217/211 ,  C03C2217/212 ,  C03C2217/213 ,  C03C2217/23 ,  C03C2217/734 ,  C03C2218/112 ,  C03C2218/113 ,  C08K3/20 ,  C09D5/006 ,  C09D7/61

Abstract: Methods and formulations are provided for: selecting a sol-gel precursor containing a material for forming a thin film layer on a substrate; selecting a solvent having a boiling point at or above a solvent boiling point threshold and a viscosity at or below a solvent viscosity threshold; combining the sol-gel and the solvent into a mixture; applying the mixture onto a surface of the substrate; permitting the mixture to spread and level on the surface; and at least one of drying and curing the mixture to form the thin layer on the substrate.

Abstract translation: 提供方法和配方：选择含有在基材上形成薄膜层的材料的溶胶 - 凝胶前体; 选择沸点等于或大于溶剂沸点阈值且粘度等于或低于溶剂粘度阈值的溶剂; 将溶胶 - 凝胶和溶剂混合成混合物; 将所述混合物施加到所述基底的表面上; 允许混合物在表面上铺展和平整; 以及干燥和固化混合物中的至少一种以在基底上形成薄层。

公开(公告)号：US12167732B2

公开(公告)日：2024-12-17

申请号：US17110389

申请日：2020-12-03

Applicant: CORNING INCORPORATED

Inventor： David Henry ,  Valerie Claudine Lacarriere

IPC: A01N57/16 ,  A01N25/04 ,  A01N63/60 ,  C12N15/11 ,  C12N15/113

Abstract: A stable aqueous suspension includes a composition which includes nanoparticles, wherein said nanoparticles include a nucleic acid at least partially encapsulated in a matrix comprising calcium phosphate. The nanoparticle compositions and suspensions have high nucleic acid loading and high stability, and may be used for protecting crops against insects and for down-regulating expression of a target gene in an insect pest species in order to prevent and/or control pest infestation.

公开(公告)号：US12103734B2

公开(公告)日：2024-10-01

申请号：US18450532

申请日：2023-08-16

Applicant: CORNING INCORPORATED

Inventor： David Henry ,  Valerie Claudine Lacarriere

IPC: B65D23/08 ,  A61J1/14 ,  B65D1/09 ,  C03C17/00 ,  C03C17/25 ,  C03C17/32 ,  C08G73/10 ,  C08K3/22 ,  C09D179/08

CPC classification number: B65D23/0814 ,  A61J1/1468 ,  B65D1/09 ,  C03C17/005 ,  C03C17/009 ,  C03C17/256 ,  C03C17/32 ,  C09D179/08 ,  C03C2217/212 ,  C03C2217/214 ,  C03C2217/22 ,  C03C2218/111 ,  C08G73/1039 ,  C08G73/105 ,  C08G73/1071 ,  C08K2003/2227 ,  C08K2003/2241 ,  C08K2003/2244 ,  C09D179/08 ,  C08K3/22 ,  C08K2003/2227 ,  C08L79/08 ,  C08K2003/2241 ,  C08L79/08 ,  C08K2003/2244 ,  C08L79/08

Abstract: According to one or more embodiments, a pharmaceutical package may include a glass container and a coating. The glass container may include a first surface and a second surface opposite the first surface. The first surface may be an outer surface of the glass container. The coating may be positioned over at least a portion of the first surface of the glass container. The coating may include one or more polyimide compositions and one or more metal oxide compositions. The one or more polyimide compositions and the one or more metal oxide compositions may be mixed in the coating.

公开(公告)号：US20240271085A1

公开(公告)日：2024-08-15

申请号：US18028961

申请日：2021-09-14

Applicant: CORNING INCORPORATED

Inventor： David Henry ,  Corinne Walerack

IPC: C12N5/00

CPC classification number: C12N5/0068 ,  C12N2533/40 ,  C12N2537/10 ,  C12N2539/10

Abstract: Activated dissolvable supports are provided comprising an ionotropically crosslinked compound comprising a polymer material having at least one repeating unit comprising an ionically crosslinked carboxylic acid group, and an activated hydroxyl group, wherein the hydroxyl group is activated by N,N′-disuccinimidyl carbonate (DSC) or N-hydroxy succinimidyl chloroformate in a solvent to form succinimidyl carbonate groups for ligand binding. Methods of forming activated dissolvable supports, culturing cells on activated dissolvable supports, and harvesting cells from dissolvable supports are provided.

公开(公告)号：US20210196585A1

公开(公告)日：2021-07-01

申请号：US17199950

申请日：2021-03-12

Applicant: Corning Incorporated

Inventor： Theresa Chang ,  Ye Fang ,  David Henry ,  Wendell Porter Weeks ,  Ying Wei

IPC: A61K8/11 ,  A61K8/73 ,  A61Q19/10 ,  A61K8/02 ,  A61K8/19 ,  A61K8/25 ,  A61K8/26

Abstract: An exfoliant composition including: a microbead comprising a core and a shell: the core comprising an abrasive particle having an average particle size of from 50 to 1,000 microns; and the shell comprising a hydrogel. Also disclosed is a method of making the exfoliant composition and a method of using the exfoliant composition.

公开(公告)号：US10900021B2

公开(公告)日：2021-01-26

申请号：US15579776

申请日：2016-06-08

Applicant: Corning Incorporated

Inventor： Paula Jean Dolley-Sonneville ,  David Henry ,  Jeffery Joseph Scibek ,  Yue Zhou

IPC: C12N5/0775 ,  C12N5/00

Abstract: A method of making a cell culture article is provided. The method includes forming a microcarrier from a microcarrier composition comprising a polygalacturonic acid compound or an alginic acid compound, infiltrating the microcarrier with a drying formulation to form an infiltrated microcarrier, and drying the infiltrated microcarrier to form a dried microcarrier, wherein the drying formulation comprises at least one of a saccharide and a monovalent cation.