公开(公告)号：US20070119945A1

公开(公告)日：2007-05-31

申请号：US11291423

申请日：2005-11-30

Applicant: Daniel Chu

Inventor： Daniel Chu

IPC: G06K7/10

CPC classification number: H02K41/0356

Abstract: A moving coil actuator contains a magnet assembly that is movable to shift the range of motion of the coil. The magnet assembly moves between two or more positions along a path of travel that is parallel to the path of travel of the reciprocating motion of the coil. With this feature, the width of an area scanned by a scanning head affixed to the coil can be increased by multiples allowing a simple moving coil actuator to be used for any scanning width.

Abstract translation: 运动线圈致动器包括可移动以移动线圈的运动范围的磁体组件。 磁体组件沿着平行于线圈的往复运动的行进路径的行进路径在两个或更多个位置之间移动。 利用该特征，由固定到线圈上的扫描头扫描的区域的宽度可以增加多倍，从而允许使用简单的移动线圈致动器用于任何扫描宽度。

公开(公告)号：US20070104414A1

公开(公告)日：2007-05-10

申请号：US11488113

申请日：2006-07-18

Applicant: Daniel Chu ,  Ying-Chih Chen ,  Shun-Tien Lee

Inventor： Daniel Chu ,  Ying-Chih Chen ,  Shun-Tien Lee

IPC: G02B6/12

CPC classification number: G02B6/02314 ,  G02B6/12002 ,  G02B6/12004 ,  G02B6/43

Abstract: An optoelectric converting substrate includes a substrate, at least one honeycomb-shaped micro-structured optical waveguide embedded in the substrate and having two ends exposed through the substrate, a plurality of optoelectronic elements disposed on the substrate and coupled with the two ends of the honeycomb-shaped micro-structured optical waveguide, and a plurality of IC driving elements disposed on the substrate and electrically connected with the optoelectronic elements by conductive wires to drive the optoelectronic elements such that optical signals are transmitted through the honeycomb-shaped micro-structured optical waveguide. The optoelectric converting substrate can be easily fabricated at a low cost and effectively increases the displacement tolerance of the optoelectronic elements in substrate packaging.

Abstract translation: 光电转换基板包括基板，至少一个蜂窝状微结构光波导，其嵌入在该基板内并且具有通过该基板露出的两端;多个光电元件，设置在该基板上并与该蜂窝体的两端连接 形状的微结构光波导，以及多个IC驱动元件，其设置在基板上并通过导线与光电元件电连接，以驱动光电元件，使得光信号通过蜂窝状微结构光波导 。 可以以低成本容易地制造光电转换基板，并有效地增加基板封装中的光电元件的位移公差。

公开(公告)号：US07034033B2

公开(公告)日：2006-04-25

申请号：US10444495

申请日：2003-05-23

Applicant: Rustum S. Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Bryan Chang

Inventor： Rustum S. Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Bryan Chang

IPC: C07D239/90 ,  A61K31/517 ,  A61P3/04 ,  A61P3/10

CPC classification number: C07D253/08 ,  C07D217/24 ,  C07D239/88 ,  C07D239/90 ,  C07D239/91 ,  C07D239/96 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D417/04 ,  C07D471/04

Abstract: A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure IA, IB, or IC where the values of the variable are defined herein.

公开(公告)号：US20060030573A1

公开(公告)日：2006-02-09

申请号：US11248040

申请日：2005-10-11

Applicant: Rustum Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Bryan Chang

Inventor： Rustum Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Bryan Chang

IPC: A61K31/519 ,  A61K31/517 ,  C07D239/88 ,  C07D403/02 ,  C07D487/02

CPC classification number: C07D253/08 ,  C07D217/24 ,  C07D239/88 ,  C07D239/90 ,  C07D239/91 ,  C07D239/96 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D417/04 ,  C07D471/04

Abstract: A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure IA, IB, or IC where the values of the variable are defined herein.

Abstract translation: 提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。 该化合物可用于治疗MC4-R介导的疾病。 化合物具有结构IA，IB或IC，其中变量的值在本文中定义。

公开(公告)号：US20050153905A1

公开(公告)日：2005-07-14

申请号：US10831522

申请日：2004-04-23

Applicant: Matthew Burger ,  Daniel Chu

Inventor： Matthew Burger ,  Daniel Chu

IPC: A61K31/7052 ,  A61P31/04 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: Antimicrobial ketolide compounds are provided having the formula (A): as well as pharmaceutically acceptable salts, esters or prodrugs thereof, pharmaceutical compositions comprising such compounds, methods of treating bacterial infections by the administration of such compounds, and processes for the preparation of the compounds.

Abstract translation: 提供具有式（A）的抗微生物酮内酯化合物：以及其药学上可接受的盐，酯或前药，包含这些化合物的药物组合物，通过施用这些化合物治疗细菌感染的方法，以及制备化合物的方法 。

公开(公告)号：US06503737B1

公开(公告)日：2003-01-07

申请号：US09410551

申请日：1999-10-01

Applicant: Christopher Reeves ,  Daniel Chu ,  Chaitan Khosla ,  Daniel Santi ,  Kai Wu

Inventor： Christopher Reeves ,  Daniel Chu ,  Chaitan Khosla ,  Daniel Santi ,  Kai Wu

IPC: C12P1962

CPC classification number: C07D498/18 ,  C07K2319/00 ,  C12N9/1029 ,  C12N9/1205 ,  C12N15/52 ,  C12P17/188 ,  C12P19/32

Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.

Abstract translation: 包含编码FK-520聚酮化合物合成酶和FK-520修饰酶的重组载体的宿主细胞可用于产生FK-520聚酮化合物。 包含一个或多个FK-520聚酮化合物结构域，模块，开放阅读框及其变体的重组DNA构建体可用于生产重组聚酮化合物合酶和各种不同的聚酮化合物，作为药物和兽用产品的应用。

公开(公告)号：US10905158B2

公开(公告)日：2021-02-02

申请号：US16181438

申请日：2018-11-06

Applicant: Jason Kang ,  Daniel Chu ,  Delia Aguilar

Inventor： Jason Kang ,  Daniel Chu ,  Delia Aguilar

IPC: A24F25/02 ,  A24F9/10 ,  A24C1/34 ,  A24C5/10 ,  C06F5/00 ,  A24F13/24 ,  A24F29/00 ,  A24F23/00 ,  A24C1/04

Abstract: The embodiments disclose an apparatus including a smoking material care kit, a matchstick and pick combination device for igniting smoking materials, a two-way humidity control pack device for controlling humidity of a smoking material stored in a smoking material protective container, and a protective container safety cap device coupled to the protective container to prevent access to smoking materials inside the protective container by children.

公开(公告)号：US20130252930A1

公开(公告)日：2013-09-26

申请号：US13881411

申请日：2011-12-16

Applicant: Daniel Chu ,  Bing Wang ,  Tao Ye

Inventor： Daniel Chu ,  Bing Wang ,  Tao Ye

IPC: C07J73/00 ,  C07J43/00 ,  C07J61/00 ,  C07J63/00

CPC classification number: C07J73/008 ,  C07D401/08 ,  C07D403/08 ,  C07D405/08 ,  C07D413/08 ,  C07D471/04 ,  C07J1/0011 ,  C07J13/005 ,  C07J21/005 ,  C07J31/006 ,  C07J43/003 ,  C07J61/00 ,  C07J63/002 ,  C07J73/003 ,  C07J73/005

Abstract: Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions. Formula (Z)

Abstract translation: 本文提供式（Z），（IX），（X），（XI），（XII），（XIII），（XIV），（XV），（XVI）的CYP11B，CYP17和/ ）或（XVII）。 本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗雄激素依赖性疾病，病症和病症的药物组合物。 式（Z）

公开(公告)号：US08420650B2

公开(公告)日：2013-04-16

申请号：US13077785

申请日：2011-03-31

Applicant: Bing Wang ,  Daniel Chu

Inventor： Bing Wang ,  Daniel Chu

IPC: A61K31/50 ,  A01N43/58 ,  C07D237/36

CPC classification number: A61K31/5025 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/5377 ,  A61K33/24 ,  A61N5/10 ,  A61N2005/1098 ,  C07D471/06

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

公开(公告)号：US20120129763A1

公开(公告)日：2012-05-24

申请号：US13358374

申请日：2012-01-25

Applicant: Daniel Chu ,  Tao Ye

Inventor： Daniel Chu ,  Tao Ye

IPC: A61K38/14 ,  A61P31/04 ,  C07K9/00

CPC classification number: C07K9/008

Abstract: Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compound C) or monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Key reaction is the treatment of properly protected intermediate compound with isocyanate or carrying a Hofmann degradation of the primary amide of the 3rd amino acid asparagines with phenyl-bis-trifluoroacetate to give the primary amine. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

Abstract translation: 具体描述了具有抗菌活性的半合成糖肽，特别是本文所述的半合成糖肽通过化学修饰糖肽（化合物A，化合物B，化合物H或化合物C）或通过水解二糖部分 在酸性介质中母体糖肽的氨基酸-4得到氨基酸-4单糖; 单糖转化为氨基糖衍生物; 在这些支架上的氨基酸4氨基取代的糖部分上的氨基取代基被某些酰基酰化; 并将这些支架的大环上的酸部分转化为某些取代的酰胺。 关键反应是用异氰酸酯处理适当保护的中间体化合物或者用苯基二 - 三氟乙酸盐对第三氨基酸天门冬酰胺的伯酰胺进行霍夫曼降解，得到伯胺。 还提供了合成化合物的方法，含有该化合物的药物组合物，以及该化合物用于治疗和/或预防疾病，特别是细菌感染的方法。