公开(公告)号：US11918354B2

公开(公告)日：2024-03-05

申请号：US16732121

申请日：2019-12-31

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark C. Shults

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/1473 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6848 ,  A61B2562/028

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US11596332B2

公开(公告)日：2023-03-07

申请号：US17390460

申请日：2021-07-30

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Rathbun K. Rhodes ,  Stuart J. Updike ,  James H. Brauker

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/15

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

公开(公告)号：US11191458B2

公开(公告)日：2021-12-07

申请号：US16284768

申请日：2019-02-25

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Rathbun K. Rhodes ,  Stuart J. Updike ,  James H. Brauker

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/15

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

公开(公告)号：US20180317827A1

公开(公告)日：2018-11-08

申请号：US16028110

申请日：2018-07-05

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Mark C. Shults ,  Mark A. Tapsak

IPC: A61B5/1473 ,  A61B5/07 ,  A61B5/1486 ,  A61L31/14 ,  A61B5/145 ,  A61L31/10

CPC classification number: A61B5/14735 ,  A61B5/076 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2562/02 ,  A61L31/10 ,  A61L31/14 ,  Y10T428/249921

Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.

公开(公告)号：US10028684B2

公开(公告)日：2018-07-24

申请号：US15711863

申请日：2017-09-21

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark C. Shults

IPC: A61B5/05 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US10028683B2

公开(公告)日：2018-07-24

申请号：US14508990

申请日：2014-10-07

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew D. Wightlin ,  Mark C. Shults

IPC: A61B5/05 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US09532741B2

公开(公告)日：2017-01-03

申请号：US14341468

申请日：2014-07-25

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Mark C. Shults ,  Mark A. Tapsak

IPC: A61B5/145 ,  A61B5/1473 ,  A61B5/07 ,  A61B5/1486 ,  A61L31/10 ,  A61L31/14

CPC classification number: A61B5/14735 ,  A61B5/076 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2562/02 ,  A61L31/10 ,  A61L31/14 ,  Y10T428/249921

Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.

Abstract translation: 本发明提供了一种用于与可植入装置一起使用的生物界面膜，其干扰屏障细胞层的形成，包括： 远离植入装置的第一区域，其中第一结构域支持组织附着并干扰阻挡细胞层形成，以及邻近可植入装置的第二结构域，其中第二结构域对细胞附着有抗性并且对细胞是不可渗透的。 此外，本发明提供了包括生物界面膜，包括这些传感器或生物界面膜的可植入装置的传感器，以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。 还提供了包括本发明的生物界面膜的其它可植入装置，例如用于细胞移植的装置，药物递送装置和电信号传递或测量装置。

公开(公告)号：US09439589B2

公开(公告)日：2016-09-13

申请号：US14553382

申请日：2014-11-25

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Stuart J. Updike ,  Rathbun K. Rhodes ,  Barbara J. Gilligan ,  Mark A. Tapsak

IPC: A61B5/00 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/1455 ,  C12Q1/00

CPC classification number: A61B5/14532 ,  A61B5/0031 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1459 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/17 ,  C12Q1/006

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

公开(公告)号：US20140378798A1

公开(公告)日：2014-12-25

申请号：US14482458

申请日：2014-09-10

Applicant: DexCom, Inc.

Inventor： Mark A. Tapsak ,  Rathbun K. Rhodes ,  Mark C. Shults ,  Jason D. McClure

IPC: A61B5/1473 ,  B05D5/00 ,  B05D3/00 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/1486 ,  A61B2562/028 ,  A61B2562/125 ,  A61L31/12 ,  B01D69/141 ,  B01D71/54 ,  B01D71/80 ,  B05D3/007 ,  B05D5/00 ,  C12Q1/002 ,  C12Q1/006 ,  Y10T428/31551

Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.

Abstract translation: 本发明提供了一种用于调节分析物通过其的运输的可植入膜，其包括包含第一聚合物的基质; 和分散在整个基质中的第二种聚合物，其中第二种聚合物形成微区网络，当400×放大倍率或更小时，使用光学显微镜不能观察到水合。 在一个方面，本发明的均质膜具有基本上分散在疏水性基质上的亲水性畴，以提供氧和葡萄糖转运到电化学葡萄糖传感器之间的最佳平衡。

公开(公告)号：US10154807B2

公开(公告)日：2018-12-18

申请号：US15716998

申请日：2017-09-27

Applicant: DexCom, Inc.

Inventor： Mark A. Tapsak ,  Rathbun K. Rhodes ,  Mark C. Shults ,  Jason D. McClure

IPC: A61B5/05 ,  A61B5/1486 ,  C12Q1/00 ,  A61L31/12 ,  B01D69/14 ,  B01D71/54 ,  B01D71/80 ,  A61B5/145 ,  A61B5/1473 ,  B05D3/00 ,  B05D5/00

Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.