公开(公告)号：US20120130343A1

公开(公告)日：2012-05-24

申请号：US13184644

申请日：2011-07-18

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

IPC: A61M5/31

CPC classification number: A61M5/46 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61B17/32093 ,  A61M5/158 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905 ,  G01N33/557 ,  G06F19/00

Abstract: An agent injection device is provided that is capable of injecting an agent to a known predetermined tissue depth. An injection member has an elongate injection shaft with an outlet port configured to dispense an agent at a controllable time. A controllable driver is coupled to the elongate injection shaft and is configured to drive the injection member into target tissue. A velocity control system is in communication with the controllable driver and is configured to control the velocity of the elongate injection shaft.

Abstract translation: 提供了能够将药剂注射到已知的预定组织深度的药剂注射装置。 注射构件具有细长注射轴，其具有配置成在可控制时间分配药剂的出口端口。 可控制的驱动器联接到细长注射轴并被构造成将注射构件驱动到靶组织中。 速度控制系统与可控驱动器连通，并被配置成控制细长注射轴的速度。

公开(公告)号：US08079960B2

公开(公告)日：2011-12-20

申请号：US11539945

申请日：2006-10-10

Applicant: Barry Dean Briggs ,  Dominique M. Freeman ,  Don Alden ,  Jon Hewitt Leonard ,  Dirk Boecker

Inventor： Barry Dean Briggs ,  Dominique M. Freeman ,  Don Alden ,  Jon Hewitt Leonard ,  Dirk Boecker

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/150832 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/150954 ,  A61B5/151 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15174 ,  A61B5/15176 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  A61B17/32093 ,  B01L3/5027 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver of includes a drive force generator for advancing the lancet along a path into the tissue site, and a sensor configured to detect lancet position along said path during the lancing cycle.

Abstract translation: 提供了一种刺血针驱动器，其中驾驶员在穿刺周期期间在柳叶刀上施加驱动力并且在组织部位上使用。 驱动器包括驱动力发生器，用于将刺血针沿着路径推进到组织部位;以及传感器，被配置为在穿刺周期期间沿着所述路径检测刺血针位置。

公开(公告)号：US07914465B2

公开(公告)日：2011-03-29

申请号：US11672746

申请日：2007-02-08

Applicant: Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A skin penetrating system has a housing member and a plurality of penetrating members positioned in the housing member. A tissue stabilizing device is coupled to the housing member. A user interface is configured to relay at least one of, skin penetrating performance or a skin penetrating setting.

Abstract translation: 皮肤穿透系统具有壳体构件和定位在壳体构件中的多个穿透构件。 组织稳定装置联接到壳体构件。 用户界面被配置为中继皮肤穿透性能或皮肤穿透设置中的至少一种。

公开(公告)号：US07909774B2

公开(公告)日：2011-03-22

申请号：US11674203

申请日：2007-02-13

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A cartridge houses the penetrating member. The cartridge has first and second seals coupled to the penetrating member to maintain a sterile environment around a portion of the penetration member prior to penetrating member actuation. A user interface is configured to relay at least one of, penetrating member performance or a penetrating member setting.

公开(公告)号：US07798979B2

公开(公告)日：2010-09-21

申请号：US12102455

申请日：2008-04-14

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00 ,  A61B17/14 ,  A61B17/32 ,  B65D81/00

CPC classification number: A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150664 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15182 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61M37/0015

Abstract: These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. An analyte detecting member is positioned to receive fluid from a wound created by the penetrating member. The detection member is configured to determine a concentration of an analyte in the fluid using a sample of less than 1 μL of the fluid.

Abstract translation: 本发明的这些和其它目的是在包括电动驱动力发生器的组织部位上使用的体液取样系统中实现的。 穿透构件可操作地联接到力发生器。 力产生器将构件沿着路径移动离开具有穿透构件出口的壳体，进入组织部位，在组织部位停止，并从组织部位抽出。 分析物检测构件定位成从由穿透构件产生的伤口接收流体。 检测构件被配置为使用小于1μL的流体的样品来确定流体中的分析物的浓度。

公开(公告)号：US07713214B2

公开(公告)日：2010-05-11

申请号：US10324053

申请日：2002-12-18

Applicant: Dominique M. Freeman ,  Dirk Boecker

Inventor： Dominique M. Freeman ,  Dirk Boecker

IPC: A61B5/00

CPC classification number: A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150664 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15182 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61M37/0015

Abstract: A device for use with a penetrating member driver to penetrate tissue is provided. The device includes a single cartridge coupled to a plurality of penetrating members and operatively couplable to the penetrating member driver. The penetrating members are movable to extend radially outward from the cartridge to penetrate tissue. A plurality of optical analyte sensors are coupled to the single cartridge and positioned to receive body fluid from a wound in the tissue created by the penetrating member.

Abstract translation: 提供了一种用于穿透构件驱动器以穿透组织的装置。 该装置包括联接到多个穿透构件并且可操作地联接到穿透构件驱动器的单个筒。 穿透构件可移动以从筒体径向向外延伸以穿透组织。 多个光学分析物传感器耦合到单个盒并定位成从穿透构件产生的组织中的伤口接收体液。

公开(公告)号：US07682318B2

公开(公告)日：2010-03-23

申请号：US10363508

申请日：2002-06-12

Applicant: Don Alden ,  Dominique M. Freeman ,  Paul Lum ,  Vladimir Drbal ,  Catherine K. Templin ,  Dirk Boecker

Inventor： Don Alden ,  Dominique M. Freeman ,  Paul Lum ,  Vladimir Drbal ,  Catherine K. Templin ,  Dirk Boecker

IPC: A61B5/00

CPC classification number: A61B5/15186 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150412 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150916 ,  A61B5/15111 ,  A61B5/15117 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15174

Abstract: Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analyzed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniaturized and/or disposable.

Abstract translation: 可以收集血液样本而没有来自环境空气的实质污染，使得可以准确地分析血液样品用于气体组分如氧气和二氧化碳。 该装置的一个实施例具有集成的致动，采血和采样部件，其在一些实施例中是小型化和/或一次性的。

公开(公告)号：US07648468B2

公开(公告)日：2010-01-19

申请号：US10335252

申请日：2002-12-31

Applicant: Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

Inventor： Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A body fluid sampling system for use on a tissue site includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A cartridge houses the penetrating member. The cartridge has first and second seals coupled to the penetrating member to maintain a sterile environment around a portion of the penetration member prior to penetrating member actuation.

Abstract translation: 用于组织部位的体液取样系统包括电动驱动力发生器。 穿透构件可操作地联接到力发生器。 力产生器将构件沿着路径移动离开具有穿透构件出口的壳体，进入组织部位，在组织部位停止，并从组织部位抽出。 墨盒容纳穿透构件。 筒具有联接到穿透构件的第一和第二密封件，以在穿透构件致动之前保持穿透构件的一部分周围的无菌环境。

公开(公告)号：US07537571B2

公开(公告)日：2009-05-26

申请号：US10363507

申请日：2002-06-12

Applicant: Dominique M. Freeman ,  Ganapati Mauze ,  Dirk Boecker

Inventor： Dominique M. Freeman ,  Ganapati Mauze ,  Dirk Boecker

IPC: A61B5/00

CPC classification number: A61B5/157 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15087 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15163 ,  A61B5/15176 ,  G01N15/06 ,  G01N33/49 ,  G01N2015/0065 ,  G01N2015/0693 ,  G01N2035/00891

Abstract: A simple, miniaturized, disposable acquisition and test module for monitoring glucose or other analytes successively for multiple times is described. The apparatus is designed to collect and test small volumes of blood in a single step. Many samples can be acquired and analyzed using a single disposable sampling module, minimizing the number of disposables and improving ease of use of the system.

Abstract translation: 描述了一种用于多次连续监测葡萄糖或其他分析物的简单，小型化的一次性采集和测试模块。 该装置被设计成在一个步骤中收集和测试小体积的血液。 可以使用单个一次性取样模块获取和分析许多样品，从而最大限度地减少一次性物品的数量并提高系统的易用性。

公开(公告)号：US07524293B2

公开(公告)日：2009-04-28

申请号：US10335073

申请日：2002-12-31

Applicant: Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00 ,  A61B17/32 ,  A61B17/14 ,  B65D81/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A body fluid sampling system for use on a tissue site includes a single drive force generator. A plurality of penetrating members are operatively coupled to the force generator. The force generator moves each of the members along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A flexible support member couples the penetrating members to define a linear array. The support member is movable and configured to move each of the penetrating members to a launch position associated with the force generator.

Abstract translation: 用于组织部位的体液取样系统包括单个驱动力发生器。 多个穿透构件可操作地联接到力发生器。 力产生器沿着路径将每个构件沿穿过壳体的穿透构件出口移动到组织部位中，停止在组织部位中，并从组织部位中退出。 柔性支撑构件将穿透构件联接以限定线性阵列。 支撑构件是可移动的并且构造成将每个穿透构件移动到与力发生器相关联的发射位置。