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公开(公告)号：US20220098233A1
公开(公告)日：2022-03-31
申请号：US17545419
申请日：2021-12-08
Applicant: EMD Millipore Corporation
Inventor： Matthew T. Stone , John P. Amara
Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.
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12.发明申请SELECTIVE REMOVAL OF A PROTEIN FROM A MIXTURE OF PROTEINS USING ACTIVATED CARBON BY ADJUSTING SOLUTION CONDITIONS 审中-公开通过调节溶液条件，使用活性炭从蛋白质混合物中选择性去除蛋白质公开(公告)号：US20150376232A1
公开(公告)日：2015-12-31
申请号：US14768267
申请日：2014-02-11
Applicant: EMD MILLIPORE CORPORATION
Inventor： Matthew T. Stone , Mikhail Kozlov
CPC classification number: C07K1/36 , C07K1/22 , C07K16/065 , C07K2317/14
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
Abstract translation: 本发明提供新颖和改进的蛋白质纯化方法，其包含某些类型的碳质材料，并且导致有效和选择性地除去某些不需要的杂质，而不会不利地影响所需蛋白质产物的产率。
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公开(公告)号：US11236125B2
公开(公告)日：2022-02-01
申请号：US16561453
申请日：2019-09-05
Applicant: EMD Millipore Corporation
Inventor： Matthew T. Stone , John P. Amara
Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.
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公开(公告)号：US20210047430A1
公开(公告)日：2021-02-18
申请号：US17088659
申请日：2020-11-04
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Chia-Yun Sun , Melissa Holstein , Kristen Cotoni , Matthew T. Stone , Santosh Rahane
IPC: C07K16/34 , C07K1/22 , B01D15/38 , B01D15/42 , B01D15/20 , B01J20/289 , B01J20/285 , B01J20/32
Abstract: Embodiments described herein relate to novel chromatography media for removing anti-A and/or anti-B antibodies from a sample, as well as methods of using the same. The media described herein have several advantages over previously described media including, acid and alkaline stability.
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