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公开(公告)号：US20210163456A1
公开(公告)日：2021-06-03
申请号：US17045952
申请日：2019-04-08
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Gregg F. KEANEY , John WANG , Baudouin GERARD , Kenzo ARAI , Xiang LIU , Guo Zhu ZHENG , Kazunobu KIRA , Lisa A. MARCAURELLE , Marta NEVALAINEN , Ming-Hong HAO , Morgan Welzel O'SHEA , Parcharee TIVITMAHAISOON , Sudeep PRAJAPATI , Touping LUO , Nicholas C. GEARHART , Jason T. LOWE , Yoshihiko KOTAKE , Satoshi NAGAO , Regina Mikie KANADA SONOBE , Masayuki MIYANO , Norio MURAI , Andrew COOK , Shelby ELLERY , Atsushi ENDO , James PALACINO , Dominic REYNOLDS
IPC: C07D407/06 , C07D405/14 , A61P35/00 , C07D313/00 , C07D491/107 , C07D487/08 , C07D487/10 , A61K45/06 , C07D405/12 , C07D417/12 , C07D413/12
Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
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公开(公告)号：US20200055883A1
公开(公告)日：2020-02-20
申请号：US16486954
申请日：2018-02-16
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Dae-Shik KIM , Frank FANG , Atsushi ENDO , Hyeong-wook CHOI , Ming-Hong HAO , Xingfeng BAO , Kuan-Chun HUANG
IPC: C07F9/6587
Abstract: Provided herein are compounds useful for the treatment of cancer.
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公开(公告)号：US20190263826A1
公开(公告)日：2019-08-29
申请号：US16284405
申请日：2019-02-25
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Charles E. CHASE , Atsushi ENDO , Francis G. FANG , Jing LI
IPC: C07D493/20 , C07D405/14 , C07D493/04 , C07D493/08 , C07D307/33 , C07D307/28 , C07D493/18 , C07D405/06 , C07D309/16 , C07D307/26 , C07D307/20 , C07D493/22
Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
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公开(公告)号：US20180237468A1
公开(公告)日：2018-08-23
申请号：US15898533
申请日：2018-02-17
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Dae-Shik KIM , Frank FANG , Atsushi ENDO , Hyeong-Wook CHOI , Ming-Hong HAO , Xingfeng BAO , Kuan-Chun HUANG
CPC classification number: C07H21/02 , A61K31/7084 , A61P31/04 , A61P35/02 , A61P37/04 , C07F9/6587 , C07H21/00
Abstract: Provided herein are compounds useful for the treatment of cancer.
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Patent Agency Ranking
公开(公告)号：US20160376294A1
公开(公告)日：2016-12-29
申请号：US15196600
申请日：2016-06-29
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Atsushi ENDO , Charles E. CHASE , Francis G. FANG
IPC: C07F7/18
CPC classification number: C07F7/1804 , C07D307/12 , C07D307/38 , C07D405/06 , C07D405/12 , C07D407/06 , C07D493/04 , Y02P20/55
Abstract: In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate. Exemplary compounds are of formula (I), (II), or (III):
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公开(公告)号：US20240368140A1
公开(公告)日：2024-11-07
申请号：US18582548
申请日：2024-02-20
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Gregg F. KEANEY , John WANG , Baudouin GERARD , Kenzo ARAI , Xiang LIU , Guo Zhu ZHENG , Kazunobu KIRA , Lisa A. MARCAURELLE , Marta NEVALAINEN , Ming-Hong HAO , Morgan Welzel O'SHEA , Parcharee TIVITMAHAISOON , Sudeep PRAJAPATI , Tuoping LUO , Nicholas C. GEARHART , Jason T. LOWE , Yoshihiko KOTAKE , Satoshi NAGAO , Regina Mikie KANADA SONOBE , Masayuki MIYANO , Norio MURAI , Andrew COOK , Shelby ELLERY , Atsushi ENDO , James PALACINO , Dominic REYNOLDS
IPC: C07D407/06 , A61K45/06 , A61P35/00 , C07D313/00 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D487/10 , C07D491/107
Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
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公开(公告)号：US20180037588A1
公开(公告)日：2018-02-08
申请号：US15787268
申请日：2017-10-18
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Charles E. CHASE , Atsushi ENDO , Francis G. FANG , Jing LI
IPC: C07D493/18 , C07D405/14 , C07D307/26 , C07D309/16 , C07D307/20 , C07D493/04 , C07D405/06
CPC classification number: C07D493/20 , C07D307/20 , C07D307/26 , C07D307/28 , C07D307/33 , C07D309/16 , C07D405/06 , C07D405/14 , C07D493/04 , C07D493/08 , C07D493/18 , C07D493/22 , Y02P20/55
Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
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公开(公告)号：US20180030045A1
公开(公告)日：2018-02-01
申请号：US15670904
申请日：2017-08-07
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： J. Eric CARLSON , Hans HANSEN , Lynn HAWKINS , Sally ISHIZAKA , Matthew MACKEY , Shawn SCHILLER , Chikako OGAWA , Heather DAVIS , Atsushi ENDO
IPC: C07D417/14 , C07D413/04 , C07D401/10 , C07D401/14 , C07D471/10 , C07D487/10 , C07D471/04 , C07D215/48 , C12Q1/68 , G01N33/50 , C07D451/04 , C07D487/04 , C07D493/10 , C07D413/14 , C07D403/14
CPC classification number: C07D417/14 , C07B2200/07 , C07D215/48 , C07D401/10 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D493/10 , C12Q1/6897 , G01N33/5023 , G01N33/5047
Abstract: Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US20160214992A1
公开(公告)日：2016-07-28
申请号：US15092850
申请日：2016-04-07
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Charles E. CHASE , Atsushi ENDO , Francis G. FANG , Jing LI
IPC: C07D493/22 , C07D493/04
CPC classification number: C07D493/20 , C07D307/20 , C07D307/26 , C07D307/28 , C07D307/33 , C07D309/16 , C07D405/06 , C07D405/14 , C07D493/04 , C07D493/08 , C07D493/18 , C07D493/22 , Y02P20/55
Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
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