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公开(公告)号：US20190264259A1
公开(公告)日：2019-08-29
申请号：US16370342
申请日：2019-03-29
Applicant: FUJIFILM Corporation
Inventor： Yuki INOUE , Takayuki TSUJIMOTO , Toshiyuki NAKATANI
IPC: C12Q1/686 , C12Q1/6869 , C12Q1/6827
Abstract: Provided are a method for discriminating an origin of human genomic DNA of 100 pg or less by uniformly amplifying human genomic DNA of 100 pg or less, a method for identifying an individual, and a method for analyzing a level of engraftment of hematopoietic stem cells.
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公开(公告)号：US20180247019A1
公开(公告)日：2018-08-30
申请号：US15964326
申请日：2018-04-27
Applicant: FUJIFILM Corporation
Inventor： Takayuki TSUJIMOTO
IPC: G06F19/24 , C12Q1/6869 , G06F19/22
CPC classification number: G16B40/00 , C12N15/09 , C12Q1/68 , C12Q1/6809 , C12Q1/6869 , C12Q1/6876 , G16B20/00 , G16B30/00 , C12Q2600/156
Abstract: Provided is a method for determining whether cells or cell groups that have a possibility of being derived from a plurality of persons are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, the method including: a step of acquiring genotypic data for gene polymorphism sites of the cells or cell groups and weighting the data with a preset weight distribution, to acquire weighted genotypic data; and a step of using the weighted genotypic data to determine whether the cells or cell groups are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, in which the preset weight distribution is set by mapping of a measured apparent genotype and a true genotype with respect to the gene polymorphism sites, and the method being capable of determining, with high accuracy, whether the cells or cell groups are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, even in a case where errors due to DNA amplification and sequencing are large and errors frequently occur in thus obtained polymorphism information of genes in genetic analysis for a small amount of deoxyribonucleic acid (DNA).
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13.发明申请公开(公告)号：US20180201988A1
公开(公告)日：2018-07-19
申请号：US15921061
申请日：2018-03-14
Applicant: FUJIFILM Corporation
Inventor： Takayuki TSUJIMOTO
IPC: C12Q1/6853 , G06F19/20
CPC classification number: C12Q1/6853 , C12N15/09 , C12Q1/68 , G16B25/00
Abstract: A method for designing a primer supplied to a PCR reaction includes a primer designing step of defining a 5′-end-side base sequence of the primer so as to include a base sequence or its complementary base sequence, the base sequence enabling identification of, among thermal cycles in the PCR reaction, a synthesis cycle of a DNA molecule in an amplification product obtained by the PCR reaction performed with the primer, the identification being based on base-sequence data obtained by sequencing the amplification product.
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公开(公告)号：US20180087112A1
公开(公告)日：2018-03-29
申请号：US15712785
申请日：2017-09-22
Applicant: FUJIFILM Corporation
Inventor： Aya OUCHI , Takayuki TSUJIMOTO , Masaya NAGASE , Yasuyuki ISHII
IPC: C12Q1/6883 , C12N15/10
CPC classification number: C12Q1/6883 , C12N15/09 , C12N15/1089 , C12Q1/6811 , C12Q1/6876 , C12Q2600/156 , C12Q2600/16 , C12Q2535/122 , C12Q2537/165
Abstract: Provided is a method for determining a genetic condition of a fetus, the method including: an objective region selection step of selecting an objective region for determining the genetic condition, from regions on a human genome; a step of isolating a single cell from a maternal blood sample; a step of extracting genomic DNA from the single cell; a step of performing PCR amplification on the objective region using a primer set designed so as to perform the PCR amplification on the objective region using genomic DNA extracted from the single cell as a template; and a DNA sequencing step of decoding a DNA base sequence of a PCR amplification product of the objective region, in which the primer set designed so as to perform the PCR amplification on the objective region is designed through a method for designing a primer set used for the polymerase chain reaction, the method for designing a primer set including a first stage selection step based on a local alignment score and a second stage selection step based on a global alignment score.
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公开(公告)号：US20170010455A1
公开(公告)日：2017-01-12
申请号：US15271634
申请日：2016-09-21
Applicant: FUJIFILM Corporation
Inventor： Takayuki TSUJIMOTO
CPC classification number: G02B21/244 , G01N33/483 , G02B7/28 , G02B7/36 , G02B21/36 , G02B21/365 , G06T7/0012 , G06T2207/10056 , G06T2207/30024 , H04N5/2256 , H04N5/23212
Abstract: The cell imaging control device includes a cell detection unit 22 that acquires a cell image by imaging transmitted light or reflected light of undyed cells and detects the cells or structures in the cells in the cell image and an autofocus control unit 24 that calculates an autofocus evaluation value based on image information of the cells or the structures detected by the cell detection unit 22 and outputs an autofocus control signal based on the autofocus evaluation value to an imaging device for capturing the cell image, which is an imaging device having an autofocus function.
Abstract translation: 细胞成像控制装置包括细胞检测单元22，其通过对未染色细胞的透射光或反射光进行成像而获取细胞图像，并检测细胞图像中的细胞中的细胞或结构;以及自动聚焦控制单元24，其计算自动聚焦评价 基于单元的图像信息或由单元检测单元22检测到的结构的值，并将基于自动聚焦评估值的自动聚焦控制信号输出到用于捕获作为具有自动聚焦功能的成像装置的单元图像的成像装置。
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Patent Agency Ranking
16.发明公开公开(公告)号：US20230306592A1
公开(公告)日：2023-09-28
申请号：US18167029
申请日：2023-02-09
Applicant: FUJIFILM Corporation
Inventor： Takayuki TSUJIMOTO , Shumpei Kamon
CPC classification number: G06T7/0012 , A61B1/000096 , A61B1/000094 , A61B1/0005 , G06T2207/10068 , G06T2207/30096 , G06T2207/20084
Abstract: A processor of an image processing device acquires a medical image including a lesion region, and causes a determiner to perform a determination process of determining a type of a lesion on the basis of the medical image. A first determination process is a process of determining whether the type belongs to a first group including a first type classified as a first category and a second type classified as a second category or a second group including a third type classified as the second category. A second determination process is a process of determining whether the type is the first type or the second type. The processor outputs a first signal for specifying whether the type is classified as the first category or the second category on the basis of a determination result of the first determination process and a determination result of the second determination process.
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公开(公告)号：US20230220375A1
公开(公告)日：2023-07-13
申请号：US18174225
申请日：2023-02-24
Applicant: FUJIFILM Corporation
Inventor： Masaya NAGASE , Masayo ASANUMA , Takayuki TSUJIMOTO , Kengo GOTO
CPC classification number: C12N15/1048 , C12N15/1072 , B01L3/5085
Abstract: Provided is a design method for dividing primer pairs into reaction containers, the design method showing an optimum division example. The design method for dividing primer pairs into reaction containers has a design step of, for a plurality of target nucleic acids, designing a plurality of primer pairs each composed of two types of primers, an evaluation step of evaluating non-specific amplification inducibility between the primer pairs, and an assignment step of performing an assignment to the reaction containers, based on the non-specific amplification inducibility, such that primer pairs having the non-specific amplification inducibility are not present in the same reaction container. The assignment step has a graph generation step of generating a graph having the primer pairs as vertices and non-specific amplification inducibility as an edge or a data structure equivalent to the graph, a coloring step of applying a solution to a graph coloring problem or the like to the graph to perform coloring such that the vertices adjacent to each other have different colors, and an association step of associating the plurality of colors with the reaction containers to associate the primer pair with the reaction containers of the corresponding colors.
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公开(公告)号：US20190221287A1
公开(公告)日：2019-07-18
申请号：US16370434
申请日：2019-03-29
Applicant: FUJIFILM Corporation
Inventor： Takayuki TSUJIMOTO
IPC: G16B25/20 , C12Q1/6876
CPC classification number: G16B25/20 , C12N15/09 , C12Q1/68 , C12Q1/6876 , C12Q2600/16 , G16B25/00
Abstract: There is provided a method for designing primers for multiplex PCR, in which, as a result of designing primers in candidate amplification regions for which priorities are set, if the number of candidate amplification regions in which primers are successfully designed does not reach a desired value, primers can be redesigned while a broad feature of previously set priorities is maintained.
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公开(公告)号：US20180355433A1
公开(公告)日：2018-12-13
申请号：US16106274
申请日：2018-08-21
Applicant: FUJIFILM Corporation
Inventor： Takayuki TSUJIMOTO
IPC: C12Q1/6883 , G06F19/22
CPC classification number: C12Q1/6883 , C12N15/09 , C12Q1/68 , C12Q2600/156 , C12Q2600/16 , G06F19/22
Abstract: Provided is a chromosome number determination method of chromosomes of interest, including: a step of performing multiplex PCR for simultaneously amplifying a plurality of loci on the chromosomes using genomic DNA extracted from a single cell or a small number of cells as templates, in which the number of loci on the chromosomes of interest is greater than or equal to 80 per chromosome, and a plurality of primer sets used in the multiplex PCR are designed through a method for designing primer sets used in a polymerase chain reaction including a first stage selection step based on a local alignment score and a second stage selection step based on a global alignment score.
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公开(公告)号：US20180032669A1
公开(公告)日：2018-02-01
申请号：US15720384
申请日：2017-09-29
Applicant: FUJIFILM Corporation
Inventor： Takayuki TSUJIMOTO
Abstract: Provided is a method for designing a primer used for a polymerase chain reaction including: a local alignment step of obtaining a local alignment score by performing pairwise local alignment on a base sequence of a primer candidate under a condition that a partial sequence to be subjected to comparison includes the 3′ terminal of the base sequence of the primer candidate; and a global alignment step of obtaining a global alignment score by performing pairwise global alignment on a base sequence which has a predetermined sequence length and includes the 3′ terminal of the base sequence of the primer candidate and a primer set.
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