摘要:
The present invention relates to compounds of the following structural formula: which are useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要:
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要:
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要:
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要:
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要:
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要:
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要:
A method of performing a cancellation of concurrent worker objects includes creating a plurality of concurrent worker objects with a manager object. At least one cancellation object is generated with the manager object. The at least one cancellation object includes a cancel method and a register method that support concurrent calls. A callback function is registered by calling the register method with one of the concurrent worker objects. A cancellation of the concurrent worker objects is requested by calling the cancel method with the manager object.
摘要:
A method of storing per-thread, per-instance data, includes identifying a unique index value corresponding to a first instance, identifying type parameters based on the identified index value, and instantiating a generic holder object based on the identified type parameters. The generic holder object includes a thread local field configured to store per-thread data that is local to the first instance.
摘要:
A query that identifies an input data source is received. The input data source is partitioned into a plurality of partitions. Each of the partitions includes a set of data elements with an associated set of indices for indicating an ordering of the data elements. A query type for a query operator in the received query is identified. It is determined whether a reordering of data elements will be performed based on the identified query type. The data elements in at least one of the partitions are reordered when it is determined based on the identified query type that reordering will be performed.