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公开(公告)号:US5891902A
公开(公告)日:1999-04-06
申请号:US676177
申请日:1996-07-15
申请人: Daisuke Machii , Haruki Takai , Nobuo Kosaka , Hisakatsu Seo , Tomomi Sugiyama , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi , Soichiro Sato , Masako Uchii , Koji Suzuki
发明人: Daisuke Machii , Haruki Takai , Nobuo Kosaka , Hisakatsu Seo , Tomomi Sugiyama , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi , Soichiro Sato , Masako Uchii , Koji Suzuki
IPC分类号: C07D209/30 , C07D209/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D521/00 , A61K31/40 , C07D209/12 , C07D209/14
CPC分类号: C07D231/12 , C07D209/30 , C07D209/42 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The present invention relates to indole derivatives represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, --O--(CH.sub.2).sub.n --OR.sup.5, or ##STR2## R.sup.3 represents hydrogen, lower alkyl, or ##STR3## R.sup.4 represents hydroxy, lower alkoxy, substituted or unsubstituted aryloxy, or --NR.sup.10 R.sup.11, and X represents CO or SO.sub.2, with the proviso that when R.sup.3 is hydrogen or lower alkyl, and X is CO, R.sup.4 is --NR.sup.10 R.sup.11, or pharmaceutically acceptable salts thereof.
摘要翻译: 本发明涉及由式(I)表示的吲哚衍生物:其中R1和R2独立地表示氢,低级烷基,羟基,低级烷氧基,卤素,-O-(CH2)n-OR5或 R 3表示氢,低级烷基或R 4表示羟基,低级烷氧基,取代或未取代的芳氧基或-NR 10 R 11,X表示CO或SO 2,条件是当R 3为氢或低级烷基时,X 是CO,R 4是-NR 10 R 11,或其药学上可接受的盐。
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公开(公告)号:US5727131A
公开(公告)日:1998-03-10
申请号:US139710
申请日:1993-10-22
申请人: Joji Nakamura , Hiroaki Tanaka , Tomohisa Yoshimi , Takayoshi Kawai , Yuji Ito , Yuji Takeo
发明人: Joji Nakamura , Hiroaki Tanaka , Tomohisa Yoshimi , Takayoshi Kawai , Yuji Ito , Yuji Takeo
CPC分类号: G06N3/0454 , G06N3/08
摘要: A learning device that affects only the input-output relationships that should be additionally learned. A learning NN unit 8 capable of executing additional learning is provided separately from a learned NN unit 4 which is a basic control unit. The learned NN unit 4 produces a basic output in response to an input signal from a signal input unit 14, the learning NN unit 8 produces a correction amount desired by an individual person, and a desired control is performed based on the total value. When the output is changed, a difference is calculated between the changed output value and the basic output value from a first output unit 15, and the learning NN unit 8 executes the additional learning based upon the difference and the input value at this moment in compliance with a back-propagation method.
摘要翻译: 仅影响应该额外学习的输入 - 输出关系的学习设备。 与作为基本控制单元的学习NN单元4分开提供能够执行附加学习的学习NN单元8。 所学习的NN单元4响应于来自信号输入单元14的输入信号产生基本输出,学习NN单元8产生个人期望的校正量,并且基于总值执行期望的控制。 当输出改变时,在改变的输出值和来自第一输出单元15的基本输出值之间计算差值,并且学习NN单元8基于此时的差异和输入值执行附加学习 具有反向传播方法。
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公开(公告)号:US5374634A
公开(公告)日:1994-12-20
申请号:US84480
申请日:1993-07-01
申请人: Iwao Kinoshita , Yasuo Onoda , Haruki Takai , Nobuo Kosaka , Akio Ishii , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi
发明人: Iwao Kinoshita , Yasuo Onoda , Haruki Takai , Nobuo Kosaka , Akio Ishii , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi
IPC分类号: A61K31/44 , A61K31/445 , A61K31/535 , A61K31/54 , C07D213/74 , C07D213/81 , C07D401/12 , A61K31/495 , C07D211/78 , C07D401/00
CPC分类号: A61K31/54 , A61K31/44 , A61K31/445 , A61K31/535 , C07D213/74 , C07D213/81 , C07D401/12
摘要: There is provided a pyridine derivative represented by the formula (I) ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or lower alkyl and each of R.sup.3 and R.sup.4 independently represents hydrogen, lower alkyl, alicyclic alkyl, substituted or unsubstituted polycyclic alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic group, or R.sup.3 and R.sup.4 are combined with nitrogen atom adjacent thereto to form a substituted or unsubstituted alicyclic heterocyclic group, or pharmaceutically acceptable salt thereof. The pyridine derivative exhibits bone resorption inhibiting effect and is useful as a medicament for treating osteoporosis.
摘要翻译: 提供由式(I)表示的吡啶衍生物,其中R 1和R 2各自独立地表示氢或低级烷基,R 3和R 4各自独立地表示氢,低级烷基,脂环族烷基,取代或未取代的 多环烷基,取代或未取代的芳基或取代或未取代的杂环基,或R 3和R 4与与其相邻的氮原子合并形成取代或未取代的脂环族杂环基或其药学上可接受的盐。 吡啶衍生物显示骨吸收抑制作用,可用作治疗骨质疏松症的药物。
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公开(公告)号:US5118220A
公开(公告)日:1992-06-02
申请号:US465251
申请日:1990-08-08
申请人: Kihachior Furumi , Joji Nakamura
发明人: Kihachior Furumi , Joji Nakamura
CPC分类号: E21D9/001 , E21D13/00 , E21D9/008 , E21D9/0671 , E21D9/087 , E21D9/0873
摘要: A method of forming an underground cavern aiming at forming an underground cavern of a large scale at a very deep place in soft ground and soft rock layers safely and economically, and a tunneling machine suitable for use in carrying out the method. This method of forming an underground cavern consists of the steps of forming a ground reinforcing zone around a portion intended to be hollowed out before froming an underground cavern to be built, and then excavating the inside surrounded by the ground reinforcing zone. Further, the above-mentioned tunneling machine comprises a ring-shaped body having a first ring, a second ring, and a third ring; a boring device mounted between the second ring and propelling jacks for boring a plurality of holes extending radially from the inner surface of the tunnel into the ground; and a reinforcing material filling device mounted also between the second ring and the propelling jacks for filling a reinforcing material and a grout into each of the holes.
摘要翻译: PCT No.PCT / JP89 / 00602 Sec。 371日期1990年8月8日第 102(e)日期1990年8月8日PCT提交1989年6月15日PCT公布。 出版物WO89 / 日期:1989年12月28日。一种形成地下洞穴的方法,其目的是安全,经济地在软地层和软岩层中的非常深的地方形成大规模的地下洞穴,以及适用于执行的隧道机 方法。 这种形成地下洞穴的方法包括以下步骤:在要从建筑的地下洞穴开始之前,在要被挖空的部分周围形成地面加固区域,然后挖掘由地面加固区域包围的内部。 此外,上述隧道掘进机包括具有第一环,第二环和第三环的环形主体; 安装在第二环和推进千斤顶之间的钻孔装置,用于钻出从隧道的内表面径向延伸到地面中的多个孔; 以及还安装在第二环和推进千斤顶之间的加强材料填充装置,用于将增强材料和灌浆填充到每个孔中。
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公开(公告)号:US4363518A
公开(公告)日:1982-12-14
申请号:US209704
申请日:1980-11-13
申请人: Joji Nakamura , Shigetake Akanuma
发明人: Joji Nakamura , Shigetake Akanuma
CPC分类号: E21C37/06
摘要: A preliminary fracturing method of a rock bed by spouting highly pressurized water into cracks existing in the rock bed to expand these cracks. The preliminary fracturing method of a rock bed comprises drilling a hole in the rock bed by means of a drilling rod having a cutter blade mounted thereto at the leading end thereof, sealing the leading end of the drilling rod by using rock mucks, injecting a high viscosity fluid from the leading end of the drilling rod into the sealed portion of the hole thereby clogging the cracks, and finally spouting a highly pressurized water or highly pressurized high viscosity fluid from the leading end of the drilling rod thereby expanding the cracks. There is also disclosed an apparatus which is adapted to perform the preliminary fracturing of a rock bed.
摘要翻译: PCT No.PCT / JP79 / 00299 Sec。 371日期1980年9月16日 102(e)日期1980年11月13日PCT提交1979年3月13日PCT公布。 出版物WO80 / 01931 日期:1980年9月18日。通过将高压水喷射到岩床中存在的裂缝中来扩展这些裂缝,对岩床进行初步压裂。 岩石床的初步压裂方法包括:在其前端安装有切割刀片的钻杆在钻床中钻孔,用钻石密封密封钻杆的前端,注射高 粘度流体从钻杆的前端进入孔的密封部分,从而堵塞裂缝,最后从钻杆的前端喷出高压水或高压高粘度流体,从而扩大裂纹。 还公开了一种适于执行岩石床的预压裂的装置。
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公开(公告)号:US4329665A
公开(公告)日:1982-05-11
申请号:US146425
申请日:1980-05-05
申请人: Senji Kawai , Yoshihumi Morimoto , Masayuki Watanabe , Hiroshi Yamaya , Hitoshi Kurohata , Joji Nakamura
发明人: Senji Kawai , Yoshihumi Morimoto , Masayuki Watanabe , Hiroshi Yamaya , Hitoshi Kurohata , Joji Nakamura
IPC分类号: H01R13/719 , H01R13/648 , H01R13/66 , H01R13/7197 , H01R31/00 , H03H7/01
CPC分类号: H01R13/7197 , H01R31/00
摘要: A noise suppressing connector comprises a shielding casing, first and second contact pins to be connected to external circuits, and a filter including at least one capacitor and a coil wound about a core made of a ferromagnetic material. An insulative housing is enclosed by the casing, and this insulative housing has a partition defining a bore with the inner wall of the housing. The first contact pin passes through the partition to project into the bore, while the filter is disposed in the bore to be connected between the first and second contact pins. At least one conductive plate is disposed in the bore and is connected to the casing for effectively shielding the filter and for serving as a ground circuit. The space in the bore may be filled with a suitable insulative material. The number of capacitors and coils may be increased to constitute a desired filter, such as a low-pass, high-pass or band-pass filter. With this provision noises which tend to pass through the connector are blocked, while induction and radiation of interfering waves and spurious waves are effectively prevented.
摘要翻译: 噪声抑制连接器包括屏蔽壳体,要连接到外部电路的第一和第二接触引脚,以及包括至少一个电容器和缠绕在由铁磁材料制成的芯体上的线圈的滤波器。 绝缘壳体由壳体封闭,并且该绝缘壳体具有限定具有壳体的内壁的孔的隔板。 第一接触销穿过隔板突出到孔中,而过滤器设置在孔中以连接在第一和第二接触销之间。 至少一个导电板设置在孔中并且连接到壳体以有效地屏蔽过滤器并用作接地电路。 孔中的空间可以用合适的绝缘材料填充。 可以增加电容器和线圈的数量以构成期望的滤波器,例如低通,高通或带通滤波器。 通过这种设置,阻止了通过连接器的噪声,同时有效地防止了干扰波和杂散波的感应和辐射。
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公开(公告)号:US4205019A
公开(公告)日:1980-05-27
申请号:US860029
申请日:1977-12-12
申请人: Takesaburo Shima , Hiroshi Kozima , Tomio Yoshida , Joji Nakamura
发明人: Takesaburo Shima , Hiroshi Kozima , Tomio Yoshida , Joji Nakamura
IPC分类号: C08F279/04 , C08F283/06 , C08F285/00
CPC分类号: C08F283/06 , C08F279/04 , C08F285/00
摘要: A process for producing a thermoplastic resin having excellent impact resistance and processability, which comprises: polymerizing an aromatic monovinyl monomer and a vinyl cyanide monomer in the presence of an aqueous elastomeric latex, mixing with agitation the resulting copolymer latex with an aromatic monovinyl monomer and a vinyl cyanide monomer in the presence of a polyalkylene oxide and a coagulant to give a stable suspension phase, and polymerizing the mixture, and said thermoplastic resin thus produced, and a composition comprising said thermoplastic resin and a copolymer produced from an aromatic monovinyl monomer and a vinyl cyanide monomer.
摘要翻译: 一种制造具有优异的耐冲击性和加工性的热塑性树脂的方法,其包括:在水性弹性体胶乳的存在下使芳族单乙烯基单体和乙烯基氰单体聚合,将所得的共聚物胶乳与芳族单乙烯基单体和 乙烯基氰单体在聚环氧烷和絮凝剂的存在下反应,得到稳定的悬浮相,并使混合物和所制得的所述热塑性树脂聚合,以及包含所述热塑性树脂和由芳族单乙烯基单体和 乙烯基氰单体。
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公开(公告)号:US4675634A
公开(公告)日:1987-06-23
申请号:US763190
申请日:1985-08-07
申请人: Seiji Matsushita , Akira Fujishima , Isao Arika , Joji Nakamura
发明人: Seiji Matsushita , Akira Fujishima , Isao Arika , Joji Nakamura
CPC分类号: H03J3/185
摘要: In a variable capacitance tuning circuit for high-frequency signals, a first varactor diode is connected between either the receiving end or feeding end and ground, one end of a tuning coil is connected to the receiving end or feeding end, and a second varactor diode is connected between the other end of the tuning coil and ground.
摘要翻译: 在用于高频信号的可变电容调谐电路中,第一变容二极管连接在接收端或馈电端和接地之间,调谐线圈的一端连接到接收端或馈电端,第二变容二极管 连接在调谐线圈的另一端和地之间。
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公开(公告)号:US4494613A
公开(公告)日:1985-01-22
申请号:US357270
申请日:1982-03-11
申请人: Hiroaki Tamaki , Joji Nakamura
发明人: Hiroaki Tamaki , Joji Nakamura
摘要: A method and apparatus for driving a hollow pile into the ground. By using a hollow rod having a short auger fixedly secured to a leading end portion thereof, excavated earth and sand are lifted to and around the upper portion of the auger where compressed air is spouted from nozzle orifices formed in the hollow rod thereby lifting the excavated earth and sand through the hollow pile and consequently discharging the same from the hollow pile. As earth and sand are discharged from the hollow pile, the pile is sunk or driven into the ground.
摘要翻译: 一种用于将空心桩驱动到地面中的方法和装置。 通过使用固定在其前端部分上的具有短螺旋钻的中空杆,挖出的土和砂被提升到螺旋钻的上部并且在螺旋推运器的上部附近,其中压缩空气从形成在中空杆中的喷嘴孔喷出,从而提升挖掘的 通过中空桩将土和沙子排出,从而将其从中空桩排出。 由于沙沙从中空桩排出,桩被沉没或被驱动到地面上。
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公开(公告)号:US4193634A
公开(公告)日:1980-03-18
申请号:US857755
申请日:1977-12-05
申请人: Joji Nakamura , Kihachiro Furumi
发明人: Joji Nakamura , Kihachiro Furumi
CPC分类号: E21D9/1066
摘要: A method and an apparatus for excavating a tunnel, hole, channel or the like in the rock mass or in the ground by using pressurized water spouted from nozzles.The method comprises the steps of digging a hole in the rock mass, inserting a rod of a fracturing apparatus in the hole, the rod having a communicating hole formed therein and nozzles formed at the leading end thereof, jetting pressurized water from the nozzles so as to produce grooves in the hole impinged by the water jet, sealing a space around the nozzles defined by the outer periphery of the rod and an inner peripheral wall of the hole, and again allowing pressurized water to spout from the nozzles into the space thereby forming cracks in the rock mass.
摘要翻译: 一种通过使用从喷嘴喷出的加压水,在岩体或地下挖掘隧道,孔,槽等的方法和装置。 该方法包括以下步骤:挖掘岩体中的孔,将孔中的压裂装置的棒插入孔中,形成有连通孔的杆和在其前端形成的喷嘴,从喷嘴喷射加压水,以便 在由喷水冲击的孔中产生凹槽,密封由杆的外周和孔的内周壁限定的喷嘴周围的空间,并且再次允许加压水从喷嘴喷出到空间中,从而形成 岩体中的裂缝。
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