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公开(公告)号：US4637758A
公开(公告)日：1987-01-20
申请号：US576995
申请日：1984-03-16
申请人： Hiroaki Tamaki , Joji Nakamura
发明人： Hiroaki Tamaki , Joji Nakamura
摘要： A method and apparatus for driving a hollow pile into the ground. By using a hollow rod having a short auger fixedly secured to a leading end portion thereof, excavated earth and sand are lifted to and around the upper portion of the auger where compressed air is spouted from nozzle orifices formed in the hollow rod thereby lifting the excavated earth and sand through the hollow pile and consequently discharging the same from the hollow pile. As earth and sand are discharged from the hollow pile, the pile is sunk or driven into the ground.
摘要翻译： 一种用于将空心桩驱动到地面中的方法和装置。 通过使用固定在其前端部分上的具有短螺旋钻的中空杆，挖出的土和砂被提升到螺旋钻的上部并且在螺旋推运器的上部附近，其中压缩空气从形成在中空杆中的喷嘴孔喷出，从而提升挖掘的 通过中空桩将土和沙子排出，从而将其从中空桩排出。 由于沙沙从中空桩排出，桩被沉没或被驱动到地面上。
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公开(公告)号：US4494613A
公开(公告)日：1985-01-22
申请号：US357270
申请日：1982-03-11
申请人： Hiroaki Tamaki , Joji Nakamura
发明人： Hiroaki Tamaki , Joji Nakamura
摘要： A method and apparatus for driving a hollow pile into the ground. By using a hollow rod having a short auger fixedly secured to a leading end portion thereof, excavated earth and sand are lifted to and around the upper portion of the auger where compressed air is spouted from nozzle orifices formed in the hollow rod thereby lifting the excavated earth and sand through the hollow pile and consequently discharging the same from the hollow pile. As earth and sand are discharged from the hollow pile, the pile is sunk or driven into the ground.
摘要翻译： 一种用于将空心桩驱动到地面中的方法和装置。 通过使用固定在其前端部分上的具有短螺旋钻的中空杆，挖出的土和砂被提升到螺旋钻的上部并且在螺旋推运器的上部附近，其中压缩空气从形成在中空杆中的喷嘴孔喷出，从而提升挖掘的 通过中空桩将土和沙子排出，从而将其从中空桩排出。 由于沙沙从中空桩排出，桩被沉没或被驱动到地面上。
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公开(公告)号：US5789407A
公开(公告)日：1998-08-04
申请号：US424397
申请日：1995-04-25
申请人： Fumio Suzuki , Nobuaki Koike , Junichi Shimada , Shigeto Kitamura , Shunji Ichikawa , Joji Nakamura , Shizuo Shiozaki
发明人： Fumio Suzuki , Nobuaki Koike , Junichi Shimada , Shigeto Kitamura , Shunji Ichikawa , Joji Nakamura , Shizuo Shiozaki
IPC分类号： A61K31/53 , C07D487/04 , A61K31/535
CPC分类号： C07D487/04 , A61K31/53
摘要： The present invention relates to an antidepressant containing as an active ingredient a triazine derivative or a pharmaceutically acceptable salt thereof, the derivative being represented by the following Formula (I): ##STR1## in which, R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, or substituted or unsubstituted lower alkanoyl; R.sup.2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclic group; R.sup.3 represents a substituted or unsubstituted heterocyclic group; X represents a single bond, O, S, S(O), S(O).sub.2, or NR.sup.4 (in which R.sup.4 represents hydrogen, or substituted or unsubstituted lower alkyl; or R.sup.2 and NR.sup.4 are combined to form a substituted or unsubstituted 4 to 6-membered saturated heterocyclic group); and A represents N or CR.sup.5 (in which R.sup.5 represents hydrogen, or substituted or unsubstituted lower alkyl).
摘要翻译： PCT No.PCT / JP94 / 01455 Sec。 371日期1995年04月25日 102（e）日期1995年4月25日PCT 1994年9月2日PCT公布。 公开号WO95 / 07282 日期：1995年3月16日本发明涉及含有作为活性成分的三嗪衍生物或其药学上可接受的盐的抗抑郁药，该衍生物由下式（I）表示：其中，R 1表示 氢，取代或未取代的低级烷基或取代或未取代的低级烷酰基; R 2表示氢，取代或未取代的低级烷基，取代或未取代的低级烯基，取代或未取代的环烷基，取代或未取代的芳基，取代或未取代的芳烷基或取代或未取代的杂环基; R3表示取代或未取代的杂环基; X表示单键，O，S，S（O），S（O）2或NR4（其中R4表示氢或取代或未取代的低级烷基;或R2和NR4组合形成取代或未取代的4 至6元饱和杂环基）; A表示N或CR5（其中R5表示氢或取代或未取代的低级烷基）。
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公开(公告)号：US5587378A
公开(公告)日：1996-12-24
申请号：US447885
申请日：1995-05-23
申请人： Fumio Suzuki , Junichi Shimada , Nobuaki Koike , Joji Nakamura , Shizuo Shiozaki , Shunji Ichikawa , Akio Ishii , Hiromi Nonaka
发明人： Fumio Suzuki , Junichi Shimada , Nobuaki Koike , Joji Nakamura , Shizuo Shiozaki , Shunji Ichikawa , Akio Ishii , Hiromi Nonaka
IPC分类号： C07D473/06 , C07D473/08 , C07D473/12 , A61K31/52
CPC分类号： C07D473/08 , C07D473/06 , C07D473/12
摘要： Methods for the treatment of Parkinson's disease comprising administering to a patient an agent which contains, as an active ingredient, a xanthine derivative or a pharmaceutically acceptable salt thereof. The xanthine derivative is represented by the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; and R.sup.4 is cycloalkyl, --(CH.sub.2).sub.n --R.sup.5, wherein R.sup.5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4, or ##STR2## wherein Y.sup.1 and Y.sup.2 represent independently hydrogen, halogen, or lower alkyl; and Z is substituted or unsubstituted aryl, ##STR3## wherein R.sup.6 is hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m is an integer of 1 to 4, or a substituted or unsubstituted heterocyclic group; and X.sup.1 and X.sup.2 are independently O or S.
摘要翻译： 用于治疗帕金森病的方法包括向患者施用含有作为活性成分的黄嘌呤衍生物或其药学上可接受的盐的试剂。 黄嘌呤衍生物由下式表示：其中R 1，R 2和R 3独立地是氢，低级烷基，低级链烯基或低级炔基; 并且R 4是环烷基， - （CH 2）n -R 5，其中R 5表示取代或未取代的芳基或取代或未取代的杂环基; n为0〜4的整数，或者，其中Y1和Y2独立地表示氢，卤素或低级烷基; Z是取代或未取代的芳基，其中R6是氢，羟基，低级烷基，低级烷氧基，卤素，硝基或氨基; m为1〜4的整数，或取代或未取代的杂环基; X1和X2独立地为O或S.
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公开(公告)号：US5543415A
公开(公告)日：1996-08-06
申请号：US199142
申请日：1994-02-25
申请人： Fumio Suzuki , Junichi Shimada , Akio Ishii , Joji Nakamura , Shunji Ichikawa , Shigeto Kitamura , Nobuaki Koike
发明人： Fumio Suzuki , Junichi Shimada , Akio Ishii , Joji Nakamura , Shunji Ichikawa , Shigeto Kitamura , Nobuaki Koike
IPC分类号： F16B37/04 , A61K31/00 , A61K31/52 , B29C65/08 , B29C65/72 , C07D473/06 , C07D473/08 , C07D473/12 , C07D473/20 , C07D473/22 , A61K31/505
CPC分类号： A61K31/52 , C07D473/06 , C07D473/08 , F16B37/048
摘要： The present invention relates to an antidepressant containing as an active ingredient a xanthine derivative or a pharmaceutically acceptable salt thereof, the xanthine derivative being represented by Formula (I) : ##STR1## in which R.sup.1, R.sup.2, and R.sup.3 represent independently hydrogen, lower alkyl, lower alkenyl;R.sup.4 represents cycloalkyl, --(CH.sub.2).sub.n --R.sup.5 (in which R.sup.5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4), or ##STR2## (in which Y.sup.1 and Y.sup.2 represent independently hydrogen, halogen or lower alkyl; and Z represents substituted or unsubstituted aryl, ##STR3## (in which R.sup.6 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m represents an integer of 1 to 3), or a substituted or unsubstituted heterocyclic group);and X.sup.1 and X.sup.2 represent independently O or S.
摘要翻译： PCT No.PCT / JP93 / 00931 Sec。 371日期1994年2月25日 102（e）1994年2月25日PCT PCT 1993年7月7日PCT公布。 第WO94 / 01114号公报 日本时间1994年1月20日本发明涉及含有作为活性成分的黄嘌呤衍生物或其药学上可接受的盐的抗抑郁药，黄嘌呤衍生物由式（I）表示：其中R1，R2， 并且R 3独立地表示氢，低级烷基，低级烯基; R 4表示环烷基， - （CH 2）n -R 5（其中R 5表示取代或未取代的芳基或取代或未取代的杂环基; n为0〜4的整数）或
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公开(公告)号：US4962107A
公开(公告)日：1990-10-09
申请号：US321692
申请日：1989-03-10
申请人： Joji Nakamura , Kazuhiro Kubo , Shunji Ichikawa , Hajime Takahashi , Keisuke Isozumi , Toyofumi Yamada
发明人： Joji Nakamura , Kazuhiro Kubo , Shunji Ichikawa , Hajime Takahashi , Keisuke Isozumi , Toyofumi Yamada
IPC分类号： A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61P25/28 , C07D211/16 , C07D211/22 , C07D211/46 , C07D265/30 , C07D265/32 , C07D279/12 , C07D295/18 , C07D295/185
CPC分类号： C07D265/30 , C07D211/16 , C07D211/22 , C07D279/12 , C07D295/185
摘要： Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;R.sub.1 is hydrogen, halogen or trifluoromethyl;R.sub.2 is hydrogen methyl or hydroxymethyl;R.sub.3 is hydrogen or lower alkyl; andY is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia.The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.
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公开(公告)号：US5891902A
公开(公告)日：1999-04-06
申请号：US676177
申请日：1996-07-15
申请人： Daisuke Machii , Haruki Takai , Nobuo Kosaka , Hisakatsu Seo , Tomomi Sugiyama , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi , Soichiro Sato , Masako Uchii , Koji Suzuki
发明人： Daisuke Machii , Haruki Takai , Nobuo Kosaka , Hisakatsu Seo , Tomomi Sugiyama , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi , Soichiro Sato , Masako Uchii , Koji Suzuki
IPC分类号： C07D209/30 , C07D209/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D521/00 , A61K31/40 , C07D209/12 , C07D209/14
CPC分类号： C07D231/12 , C07D209/30 , C07D209/42 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to indole derivatives represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, --O--(CH.sub.2).sub.n --OR.sup.5, or ##STR2## R.sup.3 represents hydrogen, lower alkyl, or ##STR3## R.sup.4 represents hydroxy, lower alkoxy, substituted or unsubstituted aryloxy, or --NR.sup.10 R.sup.11, and X represents CO or SO.sub.2, with the proviso that when R.sup.3 is hydrogen or lower alkyl, and X is CO, R.sup.4 is --NR.sup.10 R.sup.11, or pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及由式（I）表示的吲哚衍生物：其中R1和R2独立地表示氢，低级烷基，羟基，低级烷氧基，卤素，-O-（CH2）n-OR5或 R 3表示氢，低级烷基或R 4表示羟基，低级烷氧基，取代或未取代的芳氧基或-NR 10 R 11，X表示CO或SO 2，条件是当R 3为氢或低级烷基时，X 是CO，R 4是-NR 10 R 11，或其药学上可接受的盐。
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公开(公告)号：US5727131A
公开(公告)日：1998-03-10
申请号：US139710
申请日：1993-10-22
申请人： Joji Nakamura , Hiroaki Tanaka , Tomohisa Yoshimi , Takayoshi Kawai , Yuji Ito , Yuji Takeo
发明人： Joji Nakamura , Hiroaki Tanaka , Tomohisa Yoshimi , Takayoshi Kawai , Yuji Ito , Yuji Takeo
CPC分类号： G06N3/0454 , G06N3/08
摘要： A learning device that affects only the input-output relationships that should be additionally learned. A learning NN unit 8 capable of executing additional learning is provided separately from a learned NN unit 4 which is a basic control unit. The learned NN unit 4 produces a basic output in response to an input signal from a signal input unit 14, the learning NN unit 8 produces a correction amount desired by an individual person, and a desired control is performed based on the total value. When the output is changed, a difference is calculated between the changed output value and the basic output value from a first output unit 15, and the learning NN unit 8 executes the additional learning based upon the difference and the input value at this moment in compliance with a back-propagation method.
摘要翻译： 仅影响应该额外学习的输入 - 输出关系的学习设备。 与作为基本控制单元的学习NN单元4分开提供能够执行附加学习的学习NN单元8。 所学习的NN单元4响应于来自信号输入单元14的输入信号产生基本输出，学习NN单元8产生个人期望的校正量，并且基于总值执行期望的控制。 当输出改变时，在改变的输出值和来自第一输出单元15的基本输出值之间计算差值，并且学习NN单元8基于此时的差异和输入值执行附加学习 具有反向传播方法。
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公开(公告)号：US5703085A
公开(公告)日：1997-12-30
申请号：US537770
申请日：1995-10-20
申请人： Fumio Suzuki , Nobuaki Koike , Junichi Shimada , Joji Nakamura , Shizuo Shiozaki , Shigeto Kitamura , Shunji Ichikawa , Hiroshi Kase , Hiromi Nonaka
发明人： Fumio Suzuki , Nobuaki Koike , Junichi Shimada , Joji Nakamura , Shizuo Shiozaki , Shigeto Kitamura , Shunji Ichikawa , Hiroshi Kase , Hiromi Nonaka
IPC分类号： C07D473/06 , A61K31/52 , C07D473/10 , C07D473/12
CPC分类号： C07D473/06
摘要： The present invention relates to novel xanthine derivatives and pharmaceutically acceptable salts thereof, represented by Formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 independently represent hydrogen, lower alkyl, lower alkenyl, or lower alkynyl, R.sup.4 represents lower alkyl, or substituted or unsubstituted aryl, R.sup.5 and R.sup.6 independently represent hydrogen, lower alkyl, and lower alkoxy, or R.sup.5 and R.sup.6 are combined together to represent --O--(CH.sub.2)p--O-- (p is an integer of 1 to 3), n represents 0, 1, or 2, and m represents 1 or 2. The compounds of the present invention have an adenosine A.sub.2 receptor antagonistic activity, and are useful for the treatment or prevention of various kinds of diseases caused by hyperergasia of adenosine A.sub.2 receptors (for example, Parkinson's disease, senile dementia, depression, asthma, and osteoporosis).
摘要翻译： PCT No.PCT / JP95 / 00267 Sec。 371 1995年10月20日第 102（e）1995年10月20日日期PCT提交1995年2月23日PCT公布。 公开号WO95 / 23148 日期：1995年8月31日本发明涉及由式（I）表示的新颖的黄嘌呤衍生物及其药学上可接受的盐：其中R1，R2和R3独立地表示氢，低级烷基，低级链烯基或 低级炔基，R 4表示低级烷基或取代或未取代的芳基，R 5和R 6独立地表示氢，低级烷基和低级烷氧基，或者R 5和R 6结合在一起代表-O-（CH 2）p O-（p是整数 1〜3），n表示0,1或2，m表示1或2.本发明化合物具有腺苷A2受体拮抗活性，可用于治疗或预防各种疾病 腺苷A2受体（例如帕金森病，老年性痴呆，抑郁症，哮喘和骨质疏松症）的过度高血症。
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公开(公告)号：US5565460A
公开(公告)日：1996-10-15
申请号：US367346
申请日：1995-03-03
申请人： Fumio Suzuki , Junichi Shimada , Nobuaki Koike , Shunji Ichikawa , Joji Nakamura , Tomoyuki Kanda , Shigeto Kitamura
发明人： Fumio Suzuki , Junichi Shimada , Nobuaki Koike , Shunji Ichikawa , Joji Nakamura , Tomoyuki Kanda , Shigeto Kitamura
IPC分类号： A61K31/505 , A61K31/53 , C07D487/04 , A61K31/535 , A61K31/54
CPC分类号： C07D487/04 , A61K31/505 , A61K31/53
摘要： The present invention relates to a therapeutic agent for Parkinson's disease containing as an active ingredient a polycyclic compound or a pharmaceutically acceptable salt thereof, the compound being represented by the following Formula (I): ##STR1## and A represents N or CR.sup.5 (in which R.sup.5 represents hydrogen, or substituted or unsubstituted lower alkyl), or represented by the following Formula (II): ##STR2## wherein Y, R.sup.6 and R.sup.8 are as defined herein and B and the adjacent two carbon atoms are combined to form a substituted or unsubstituted, partially saturated or unsaturated, monocyclic or bicyclic, carbocyclic or heterocyclic group.
摘要翻译： PCT No.PCT / JP94 / 01196 Sec。 371日期1995年3月3日 102（e）1995年3月3日PCT PCT 1994年7月20日PCT公布。 公开号WO95 / 03806 日期：1995年2月9日本发明涉及含有作为活性成分的多环化合物或其药学上可接受的盐的帕金森病治疗剂，该化合物由下式（I）表示：＆lt; IMAGE＆gt;（I）和 A表示N或CR 5（其中R 5表示氢或取代或未取代的低级烷基），或由下式（II）表示：其中Y，R 6和R 8如本文所定义，B和 相邻的两个碳原子结合形成取代或未取代的，部分饱和或不饱和的单环或双环，碳环或杂环基团。
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