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公开(公告)号：US08841278B2
公开(公告)日：2014-09-23
申请号：US14045717
申请日：2013-10-03
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu
IPC: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4178 , A61K31/7068 , A61K31/7052 , A61K31/4184 , A61P1/16 , A61P31/14
CPC classification number: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20130302280A1
公开(公告)日：2013-11-14
申请号：US13927355
申请日：2013-06-26
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang
IPC: C07F9/6553 , A61K45/06 , A61K31/683 , A61K31/675 , C07F9/6561 , C07F9/6568 , A61K31/67 , C07F9/6558
CPC classification number: C07F9/655345 , A61K31/662 , A61K31/67 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65586 , C07F9/6561 , C07F9/65681
Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
Abstract translation: 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US11555029B2
公开(公告)日：2023-01-17
申请号：US16891880
申请日：2020-06-03
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00 , C07K16/28
Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US20210078959A1
公开(公告)日：2021-03-18
申请号：US16925096
申请日：2020-07-09
Applicant: Gilead Sciences, Inc.
Inventor： Zhenhong R. Cai , Aesop Cho , Ana Zurisadai Gonzalez Buenrostro , Xiaochun Han , Salman Y. Jabri , Ryan McFadden , Yingmei Qi , Johannes Voigt , Jie Xu , Lianhong Xu , Hong Yang
IPC: C07D247/00 , A61P31/18 , C07D401/10 , C07D403/14 , C07D233/88 , C07D487/04 , C07D417/10 , C07D471/04 , C07D417/14 , C07D491/107 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/10 , C07D413/10
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US20210053946A1
公开(公告)日：2021-02-25
申请号：US16891880
申请日：2020-06-03
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00
Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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Patent Agency Ranking
公开(公告)号：US10899735B2
公开(公告)日：2021-01-26
申请号：US16388517
申请日：2019-04-18
Applicant: Gilead Sciences, Inc
Inventor： Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D401/10 , A61K31/444 , C07D401/04 , C07D401/12 , C07D401/14 , C07D487/10 , C07D519/00 , C07K16/28
Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US10774053B2
公开(公告)日：2020-09-15
申请号：US16158446
申请日：2018-10-12
Applicant: Gilead Sciences, Inc.
Inventor： Zhenhong R. Cai , Aesop Cho , Ana Zurisadai Gonzalez Buenrostro , Xiaochun Han , Salman Y. Jabri , Ryan McFadden , Yingmei Qi , Johannes Voigt , Hong Yang , Jie Xu , Lianhong Xu
IPC: A61K31/497 , A61K31/4439 , A61K31/433 , A61K31/4196 , A61K31/4178 , A61K31/4192 , A61K31/422 , C07D247/00 , A61P31/18 , C07D401/10 , C07D403/14 , C07D233/88 , C07D487/04 , C07D417/10 , C07D471/04 , C07D417/14 , C07D491/107 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/10 , C07D413/10 , A61K45/06
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US20160016980A1
公开(公告)日：2016-01-21
申请号：US14746430
申请日：2015-06-22
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , Michael O' Neil Hanrahan Clarke , Scott Alan Wolckenhauer
IPC: C07F9/24
CPC classification number: C07H1/00 , A61K31/7042 , A61K31/7052 , C07F9/2458 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07H19/02 , C07H19/10 , C07H19/20
Abstract: Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib: The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.
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公开(公告)号：US08822430B2
公开(公告)日：2014-09-02
申请号：US13956195
申请日：2013-07-31
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu
IPC: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4178 , A61K31/7068 , A61K31/7052 , A61K31/4184 , A61P1/16 , A61P31/14
CPC classification number: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US08765722B2
公开(公告)日：2014-07-01
申请号：US13927355
申请日：2013-06-26
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang
IPC: A61K31/67 , A61K31/675 , C07F9/6558 , C07F9/6553
CPC classification number: C07F9/655345 , A61K31/662 , A61K31/67 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65586 , C07F9/6561 , C07F9/65681
Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
Abstract translation: 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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