公开(公告)号：US20230312567A1

公开(公告)日：2023-10-05

申请号：US18110126

申请日：2023-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Chienhung Chou ,  Darryl Kato ,  Scott E. Lazerwith ,  John O. Link ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D471/04 ,  A61K45/06 ,  C07D403/12 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K45/06 ,  C07D403/12 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

公开(公告)号：US11052087B2

公开(公告)日：2021-07-06

申请号：US16525203

申请日：2019-07-29

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Zheng-Yu Yang

IPC: A61K31/506 ,  A61K31/4995 ,  C07D487/08 ,  A61P31/18

Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US20210171543A1

公开(公告)日：2021-06-10

申请号：US17094447

申请日：2020-11-10

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  David W. Lin ,  Jonathan William Medley ,  Devan Naduthambi ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang ,  QingMing Zhu

IPC: C07D513/18 ,  C07D519/00 ,  C07D513/20 ,  C07D513/08 ,  C07D513/22 ,  A61K45/06 ,  C07K16/28

Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20200331870A1

公开(公告)日：2020-10-22

申请号：US16857021

申请日：2020-04-23

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Tae H. Hwang ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  John E. Knox ,  Scott E. Lazerwith ,  Xiaofen Li ,  David W. Lin ,  Jonathan W. Medley ,  Michael L. Mitchell ,  Devan Naduthambi ,  Zachary Newby ,  Neil H. Squires ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang

IPC: C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20200030327A1

公开(公告)日：2020-01-30

申请号：US16525203

申请日：2019-07-29

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Zheng-Yu Yang

IPC: A61K31/506 ,  C07D487/08 ,  A61K31/4995 ,  A61P31/18

Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US09655944B2

公开(公告)日：2017-05-23

申请号：US15185273

申请日：2016-06-17

Applicant: Gilead Sciences, Inc.

Inventor： Kyla Bjornson ,  Eda Canales ,  Jeromy J. Cottell ,  Kapil K. Karki ,  Ashley A. Katana ,  Darryl Kato ,  Tetsuya Kobayashi ,  John O. Link ,  Ruben Martinez ,  Barton W. Phillips ,  Hyung-jung Pyun ,  Michael Sangi ,  Adam J. Schrier ,  Dustin Siegel ,  James G. Taylor ,  Chinh V. Tran ,  Teresa A. Trejo Martin ,  Randall W. Vivian ,  Zheng-Yu Yang ,  Jeff Zablocki ,  Sheila Zipfel

IPC: A61K38/21 ,  A61K38/06 ,  C07D498/16 ,  A61K31/4985 ,  C07D498/22 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/519 ,  A61K45/06 ,  C07K5/087 ,  C07K5/08 ,  C07K5/083 ,  A61K38/00

CPC classification number: A61K31/498 ,  A61K31/10 ,  A61K31/401 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K38/00 ,  A61K38/06 ,  A61K38/21 ,  A61K45/06 ,  C07D241/36 ,  C07D403/14 ,  C07D498/16 ,  C07D498/22 ,  C07K5/08 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0827 ,  A61K2300/00

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

公开(公告)号：US20150175655A1

公开(公告)日：2015-06-25

申请号：US14412331

申请日：2013-07-02

Applicant: Gilead Sciences, Inc.

Inventor： Kyla Bjornson ,  Eda Canales ,  Jeromy J. Cottell ,  Kapil Kumar Karki ,  Ashley Anne Katana ,  Darryl Kato ,  Tetsuya Kobayashi ,  John O. Link ,  Ruben Martinez ,  Barton W. Phillips ,  Hyung-Jung Pyun ,  Michael Sangi ,  Adam James Schrier ,  Dustin Siegel ,  James G. Taylor ,  Chinh Viet Tran ,  Teresa Alejandra Trejo Martin ,  Randall W. Vivian ,  Zheng-Yu Yang ,  Jeff Zablocki ,  Sheila Zipfel

IPC: C07K5/08 ,  A61K38/06 ,  A61K45/06

Abstract: Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract translation: 公开了式I的化合物，以及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。

公开(公告)号：US20150038488A1

公开(公告)日：2015-02-05

申请号：US14448160

申请日：2014-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Kevin S. Currie ,  Zhimin Du ,  Julie Farand ,  Juan A. Guerrero ,  Ashley A. Katana ,  Darryl Kato ,  Scott E. Lazerwith ,  Jiayao Li ,  John O. Link ,  Nicholas Mai ,  Gregory Notte ,  Hyung-Jung Pyun ,  Michael Sangi ,  Aaron C. Schmitt ,  Adam J. Schrier ,  Kirk L. Stevens ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Zheng-Yu Yang ,  Jeff Zablocki ,  Sheila Zipfel

IPC: C07D487/04 ,  C07D417/04 ,  C07D417/12 ,  C07D403/12 ,  C07D471/04 ,  C07D401/14

CPC classification number: C07D471/04 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D491/08 ,  C07D498/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract translation: 本公开涉及作为Syk抑制剂的化合物及其在治疗各种疾病状态（包括癌症和炎性病症）中的用途。 在具体实施方案中，化合物的结构由式I给出，其中X 1，X 2，X 3，R 2，R 3，R 4，R 5和Y如本文所述。 本公开进一步提供包含式I化合物或其药学上可接受的盐的药物组合物，以及使用这些化合物和组合物治疗由Syk介导的病症的方法。

公开(公告)号：US20140051656A1

公开(公告)日：2014-02-20

申请号：US13956195

申请日：2013-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Hongyan Guo ,  Darryl Kato ,  Thorsten A. Kirschberg ,  Hongtao Liu ,  John O. Link ,  Michael L. Mitchell ,  Jay P. Parrish ,  Jianyu Sun ,  James Taylor ,  Elizabeth M. Bacon ,  Eda Canales ,  Aesop Cho ,  Choung U. Kim ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Randall L. Halcomb ,  Michael Graupe ,  Evan S. Krygowski ,  Scott E. Lazerwith ,  Qi Liu ,  Richard L. Mackman ,  Hyung-Jung Pyun ,  Joseph H. Saugier ,  James D. Trenkle ,  Winston C. Tse ,  Randall W. Vivian ,  Scott D. Schroeder ,  William J. Watkins ,  Lianhong Xu

IPC: C07D403/14 ,  A61K45/06 ,  A61K31/4184

CPC classification number: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  A61P31/12 ,  C07D207/16 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D491/113 ,  C07D495/04 ,  C07F5/025

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130164260A1

公开(公告)日：2013-06-27

申请号：US13679862

申请日：2012-11-16

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Jeromy J. Cottell ,  Ashley Anne Kanata ,  Darryl Kato ,  Evan S. Krygowski ,  John O. Link ,  James Taylor ,  Chinh Viet Tran ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang ,  Sheila Zipfel

IPC: A61K31/4188 ,  A61K45/06

CPC classification number: C07D491/052 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7072 ,  A61K38/06 ,  A61K38/07 ,  A61K38/21 ,  A61K45/06 ,  A61K47/60 ,  C07D405/12 ,  C07F5/025 ,  Y10S514/894 ,  A61K2300/00

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.