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![Substituted 2,3,4,5,7,9,13,13a-octahydro-1,5-methanopyrido[1′,2′:4,5]pyrazino[1,2-a][1,3]diazepines and methods for treating viral infections](/abs-image/US/2018/07/31/US10035809B2/abs.jpg.150x150.jpg)
公开(公告)号：US10035809B2
公开(公告)日：2018-07-31
申请号：US15599151
申请日：2017-05-18
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Zhenhong R. Cai , Xiaowu Chen , Jeromy J. Cottell , Manoj C. Desai , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Michael R. Mish , Philip Anthony Morganelli , Hyung-Jung Pyun , James G. Taylor , Teresa Alejandra Trejo Martin
IPC: A61K31/4985 , C07D487/04 , C07D498/14 , A61K31/537 , C07D471/22 , A61K31/529 , A61K31/551 , A61K31/553 , C07D471/18 , A61K45/06 , C07D498/18 , C07D487/14 , A61K31/498
CPC classification number: C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US20180002316A1
公开(公告)日：2018-01-04
申请号：US15634314
申请日：2017-06-27
Applicant: Gilead Sciences, Inc.
Inventor： Gayatri Balan , Chien-Hung Chou , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Roland D. Saito , Neil H. Squires , James G. Taylor , William J. Watkins , Nathan E. Wright
IPC: C07D403/12 , C07D401/14 , C07D405/14 , C07D417/14
CPC classification number: C07D403/12 , C07D401/14 , C07D405/14 , C07D417/14
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US20170290827A1
公开(公告)日：2017-10-12
申请号：US15488035
申请日：2017-04-14
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila M. Zipfel
IPC: A61K31/498 , C07D403/14 , C07D241/36 , A61K31/401 , A61K31/10
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
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公开(公告)号：US20170260204A1
公开(公告)日：2017-09-14
申请号：US15599151
申请日：2017-05-18
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Zhenhong R. Cai , Xiaowu Chen , Jeromy J. Cottell , Manoj C. Desai , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Michael R. Mish , Philip Anthony Morganelli , Hyung-Jung Pyun , James G. Taylor , Teresa Alejandra Trejo Martin
IPC: C07D498/14 , C07D471/22 , A61K31/529 , A61K31/551 , A61K31/498 , C07D471/18 , A61K45/06 , C07D498/18 , C07D487/14 , A61K31/537 , A61K31/553
CPC classification number: C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US08822430B2
公开(公告)日：2014-09-02
申请号：US13956195
申请日：2013-07-31
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu
IPC: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4178 , A61K31/7068 , A61K31/7052 , A61K31/4184 , A61P1/16 , A61P31/14
CPC classification number: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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Patent Agency Ranking
公开(公告)号：US20250129051A1
公开(公告)日：2025-04-24
申请号：US18922134
申请日：2024-10-21
Applicant: Gilead Sciences, Inc.
Inventor： Robert L. Hoffman , Michael R. Mish , James G. Taylor
IPC: C07D401/14 , A61K31/444 , A61K31/4709 , A61K31/498 , A61P35/00 , C07D471/04 , C07D491/048
Abstract: Described herein are PARP1 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号：US12180197B2
公开(公告)日：2024-12-31
申请号：US17690851
申请日：2022-03-09
Applicant: Gilead Sciences, Inc.
Inventor： Gediminas J. Brizgys , Chienhung Chou , Jeromy J. Cottell , Chao-I Hung , Michael L. Mitchell , Scott D. Schroeder , Nathan D. Shapiro , Suzanne M. Szewczyk , James G. Taylor , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D405/14 , A61K31/4545 , A61K31/4725 , A61K45/06 , C07D401/14 , C07D413/14 , C07D417/14
Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.
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公开(公告)号：US20240066016A1
公开(公告)日：2024-02-29
申请号：US18372242
申请日：2023-09-25
Applicant: Gilead Sciences, Inc.
Inventor： David G. Breckenridge , Grant R. Budas , Ruchi Gupta , James G. Taylor , Matthew R. Warr , Nathan E. Wright
IPC: A61K31/4709 , A61K31/519 , A61P1/16 , A61P3/04
CPC classification number: A61K31/4709 , A61K31/519 , A61P1/16 , A61P3/04
Abstract: The present disclosure relates generally to methods of using modulators of COT (cancer Osaka thyroid) for treating, stabilizing, or lessening the severity or progression of liver disease, in particular, Nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).
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公开(公告)号：US11905299B2
公开(公告)日：2024-02-20
申请号：US17317041
申请日：2021-05-11
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Gayatri Balan , Chien-Hung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D401/12 , C07D498/04 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D401/14 , C07B59/00
CPC classification number: C07D498/04 , C07B59/002 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07B2200/05
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US11858918B2
公开(公告)日：2024-01-02
申请号：US17724212
申请日：2022-04-19
Applicant: Gilead Sciences, Inc.
Inventor： Megan K. Armstrong , James S. Cassidy , Elbert Chin , Chienhung Chou , Jeromy J. Cottell , Chao-I Hung , Kavoos Kolahdouzan , David W. Lin , Michael L. Mitchell , Ezra Roberts , Scott D. Schroeder , Nathan D. Shapiro , James G. Taylor , Rhiannon Thomas-Tran , Nathan E. Wright , Zheng-Yu Yang
IPC: C07D405/14 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/675 , C07D401/08 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D493/08 , C07D493/10 , C07F9/6558
CPC classification number: C07D405/14 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/675 , C07D401/08 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D493/08 , C07D493/10 , C07F9/65586
Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.
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