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公开(公告)号：US20180086719A1
公开(公告)日：2018-03-29
申请号：US15711875
申请日：2017-09-21
Applicant: Gilead Sciences, Inc.
Inventor： Jayaraman Chandrasekhar , Devan Naduthambi , Leena Patel , Stephane Perreault , Gary Phillips , Kassandra F. Sedillo , Nicholas Alexander Till , Jennifer Anne Treiberg , William J. Watkins
IPC: C07D235/08 , A61K31/4184
CPC classification number: C07D235/08 , A61K31/4184 , A61K31/5377 , A61K45/06 , A61K2300/00 , A61P35/02 , A61P35/04 , C07D413/04 , C07D413/14
Abstract: The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein t, R1, R2, R3, R4, and R6 are as described herein.
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公开(公告)号：US20180002316A1
公开(公告)日：2018-01-04
申请号：US15634314
申请日：2017-06-27
Applicant: Gilead Sciences, Inc.
Inventor： Gayatri Balan , Chien-Hung Chou , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Roland D. Saito , Neil H. Squires , James G. Taylor , William J. Watkins , Nathan E. Wright
IPC: C07D403/12 , C07D401/14 , C07D405/14 , C07D417/14
CPC classification number: C07D403/12 , C07D401/14 , C07D405/14 , C07D417/14
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US20170273952A1
公开(公告)日：2017-09-28
申请号：US15508968
申请日：2015-09-22
Applicant: Gilead Sciences, Inc.
Inventor： William J. Watkins
IPC: A61K31/42 , A61K45/06 , A61K9/48 , A61K31/4439
CPC classification number: A61K31/42 , A61K9/48 , A61K31/4439 , A61K45/06 , A61K2300/00
Abstract: The present disclosure relates to a method of preventing and/or treating liver disease comprising administering an ASK1 inhibitor in combination with a FXR agonist, to a patient in need thereof.
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公开(公告)号：US20170042961A1
公开(公告)日：2017-02-16
申请号：US15244926
申请日：2016-08-23
Applicant: Gilead Sciences, Inc.
Inventor： William E. Delaney, IV , John O. Link , Hongmei Mo , David W. Oldach , Adrian S. Ray , William J. Watkins , Cheng Yong Yang , Weidong Zhong
IPC: A61K38/05 , A61K31/675 , A61K31/7068 , A61K31/381 , A61K31/4184 , A61K31/501 , A61K31/706
CPC classification number: A61K38/05 , A61K31/381 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/407 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/4353 , A61K31/4436 , A61K31/501 , A61K31/5377 , A61K31/662 , A61K31/675 , A61K31/7056 , A61K31/706 , A61K31/7068 , A61K38/212 , A61K45/06 , A61K2300/00
Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.
Abstract translation: 本发明涉及可用于治疗丙型肝炎病毒感染的治疗分子的组合。 本发明涉及方法，用途，给药方案和组合物。
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公开(公告)号：US09452154B2
公开(公告)日：2016-09-27
申请号：US14513900
申请日：2014-10-14
Applicant: Gilead Sciences, Inc.
Inventor： William E. Delaney, IV , John O. Link , Hongmei Mo , David W. Oldach , Adrian S. Ray , William J. Watkins , Cheng Yong Yang , Weidong Zhong
IPC: A61K31/675 , A61K31/4184 , A61K31/381 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/407 , A61K31/4178 , A61K31/4188 , A61K31/4353 , A61K31/4436 , A61K31/662 , A61K31/7056 , A61K45/06 , A61K31/501 , A61K31/5377 , A61K38/21 , A61K31/706
CPC classification number: A61K38/05 , A61K31/381 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/407 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/4353 , A61K31/4436 , A61K31/501 , A61K31/5377 , A61K31/662 , A61K31/675 , A61K31/7056 , A61K31/706 , A61K31/7068 , A61K38/212 , A61K45/06 , A61K2300/00
Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.
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Patent Agency Ranking
公开(公告)号：US09321753B2
公开(公告)日：2016-04-26
申请号：US13939695
申请日：2013-07-11
Applicant: Gilead Sciences, Inc.
Inventor： Eda Canales , Michael O'Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Philip Anthony Morganelli , William J. Watkins
IPC: A61K31/4436 , A61K31/381 , A61K45/06 , C07D409/12
CPC classification number: C07D409/12 , A61K31/381 , A61K31/4436 , A61K45/06
Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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公开(公告)号：US08822430B2
公开(公告)日：2014-09-02
申请号：US13956195
申请日：2013-07-31
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu
IPC: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4178 , A61K31/7068 , A61K31/7052 , A61K31/4184 , A61P1/16 , A61P31/14
CPC classification number: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US08765722B2
公开(公告)日：2014-07-01
申请号：US13927355
申请日：2013-06-26
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang
IPC: A61K31/67 , A61K31/675 , C07F9/6558 , C07F9/6553
CPC classification number: C07F9/655345 , A61K31/662 , A61K31/67 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65586 , C07F9/6561 , C07F9/65681
Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
Abstract translation: 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US20130323203A1
公开(公告)日：2013-12-05
申请号：US13958424
申请日：2013-08-02
Applicant: Gilead Sciences, Inc.
Inventor： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman Belmont , Philip Anthony Morganelli , William J. Watkins
IPC: C07D333/38 , A61K31/4545 , A61K45/06 , C07D409/12 , A61K31/381 , A61K31/501 , C07D493/04 , A61K31/4535 , A61K31/454 , A61K31/497 , C07D413/12 , A61K31/427 , C07D409/14 , A61K31/4025
CPC classification number: C07D333/38 , A61K31/381 , A61K31/4025 , A61K31/427 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K45/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D493/04
Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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公开(公告)号：US20130315861A1
公开(公告)日：2013-11-28
申请号：US13939695
申请日：2013-07-11
Applicant: Gilead Sciences, Inc.
Inventor： Eda Canales , Michael O'Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Philip Anthony Morganelli , William J. Watkins
IPC: C07D409/12 , A61K45/06 , A61K31/381 , A61K31/4436
CPC classification number: C07D409/12 , A61K31/381 , A61K31/4436 , A61K45/06
Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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