公开(公告)号：US20250009874A1

公开(公告)日：2025-01-09

申请号：US18650745

申请日：2024-04-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Enrico MALITO ,  Sumana CHANDRAMOULI ,  Andrea CARFI ,  Matthew BOTTOMLEY

IPC: A61K39/245 ,  A61K47/64 ,  C07K14/005

Abstract: Described are mutant, human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.

公开(公告)号：US20240383949A1

公开(公告)日：2024-11-21

申请号：US18435026

申请日：2024-02-07

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Enrico MALITO ,  Matthew James BOTTOMLEY ,  Andrea CARFI ,  Sumana CHANDRAMOULI ,  Kate LUISI

IPC: C07K14/045 ,  A61K38/00 ,  A61K39/245

Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.

公开(公告)号：US20180265551A1

公开(公告)日：2018-09-20

申请号：US15533483

申请日：2015-12-07

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Andrea CARFI ,  Sumana CHANDRAMOULI ,  Ethan C. SETTEMBRE

IPC: C07K14/005

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  C12N2710/16122 ,  C12N2710/16134

Abstract: The invention generally relates to recombinant human cytomegalovirus (CMV) gB proteins and immunogenic fragments thereof, which do not comprise a transmembrane (TM) domain; and comprise one or more mutations that reduce the aggregation between the monomeric trimers of gB, and/or adhesion of the monomeric trimer of gB to the host cell.