公开(公告)号：US20190120854A1

公开(公告)日：2019-04-25

申请号：US15992115

申请日：2018-05-29

Applicant: GENENTECH, INC.

Inventor： Joseph R. Arron ,  Richard W. Erickson ,  Michelle Freemer ,  Meredith Hazen ,  Guiquan Jia ,  John G. Matthews ,  Wendy Putnam ,  Heleen Scheerens ,  Yanan Zheng

IPC: G01N33/68 ,  C07K16/24 ,  A61K31/573 ,  A61K31/522 ,  A61K45/06 ,  A61K39/395 ,  C07K16/28 ,  C07K16/18

Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.

公开(公告)号：US10005848B2

公开(公告)日：2018-06-26

申请号：US14725412

申请日：2015-05-29

Applicant: Genentech, Inc.

Inventor： Jackson G Egen ,  Jo-Anne Hongo ,  Steven Kauder ,  Robert A Lazarus ,  Lydia Santell ,  Yan Wu ,  Meredith Hazen ,  Wei-Ching Liang

IPC: C07K16/40 ,  C07K14/705 ,  C07K16/28 ,  C07K14/52 ,  C12Q1/68 ,  G01N33/74 ,  C12Q1/6883 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K14/52 ,  C07K14/70596 ,  C07K16/2863 ,  C07K2317/55 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/74 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2800/065 ,  G01N2800/20 ,  G01N2800/52

Abstract: This invention relates to RON compositions, in particular RON composition comprising a RON agonist, and methods of using the compositions for the treatment of diseases. The invention also relates to diagnosis of RON-associated or MSP-associated diseases.

公开(公告)号：US20150098946A1

公开(公告)日：2015-04-09

申请号：US14400684

申请日：2013-03-14

Applicant: Genentech, Inc.

Inventor： Sunil Bhakta ,  Meredith Hazen ,  Jo-Anne S Hongo ,  Jagath R Junutula ,  Isidro Hotzel ,  Yonglei Shang ,  Shang-Fan Yu

IPC: C07K16/30 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6817 ,  A61K47/6855 ,  A61K51/1051 ,  A61K2039/505 ,  A61K2039/6037 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/77 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415 ,  G01N33/57423 ,  G01N2333/47 ,  G01N2500/02

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.

Abstract translation: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。 在某些方面，分离的核酸分子包含具有至少约80％核酸序列同一性，或至少约81％，82％，83％，84％，85％，86％，87％，88 ％，89％，90％，91％，92％，93％，94％，95％，96％，97％，98％，99％或100％的核酸序列同一性。 如本文公开的具有本文公开的氨基酸序列的全长TAT多肽，缺乏本文公开的信号肽的TAT多肽氨基酸序列，跨膜TAT多肽的胞外结构域，具有或不具有信号肽。

公开(公告)号：US20140044702A1

公开(公告)日：2014-02-13

申请号：US14021947

申请日：2013-09-09

Applicant: Genentech, Inc.

Inventor： Joseph R. Arron ,  Richard W. Erickson ,  Michelle Freemer ,  Meredith Hazen ,  Guiquan Jia ,  John G. Matthews ,  Wendy Putnam ,  Heleen Scheerens ,  Yanan Zheng

IPC: G01N33/68 ,  A61K31/522 ,  A61K45/06 ,  A61K39/395 ,  A61K31/573

CPC classification number: G01N33/6884 ,  A61K31/522 ,  A61K31/573 ,  A61K39/3955 ,  A61K39/39566 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/475 ,  G01N2800/122 ,  G01N2800/52

Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.

Abstract translation: 提供了诊断和治疗与TH2抑制有关的疾病的方法，包括但不限于哮喘。 还提供了选择或鉴定患者以治疗TH2途径抑制剂的某些治疗剂的方法。