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    Stat3 antagonists and their use as vaccines against cancer
    11.
    发明授权
    Stat3 antagonists and their use as vaccines against cancer 有权
    Stat3拮抗剂及其作为疫苗的用途

    公开(公告)号：US07638122B2

    公开(公告)日：2009-12-29

    申请号：US10383707

    申请日：2003-03-07

    申请人： Hua Yu ,  Drew Pardoll ,  Richard Jove

    发明人： Hua Yu ,  Drew Pardoll ,  Richard Jove

    IPC分类号： A61K35/12 ,  A61K35/14 ,  A61K41/00

    CPC分类号： C07K16/18 ,  A61K39/0011 ,  A61K48/00 ,  A61K2039/5152 ,  A61K2039/5154 ,  A61K2039/55522 ,  C12N5/0693 ,  C12N2501/60

    摘要： The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression and/or function in tumor cells and the administration of such cells to a subject in need of treatment and/or prevention. Other methods of the invention comprise activating T-cells by co-culturing the T-cells with the tumor cells with decreased Stat3 expression or function. The invention further encompasses methods comprising decreasing Stat3 expression or function in antigen-presenting cells and co-administering tumor cells and the antigen-presenting cells with decreased Stat3 function to a patient. The invention further relates to methods for stimulating dendritic cell differentiation.

    摘要翻译： 本发明涉及治疗和/或预防癌症的方法。 特别地，本发明涉及离体免疫治疗方法。 所述方法包括降低Stat3（信号转导和转录激活因子3）在肿瘤细胞中的表达和/或功能，并将此类细胞施用于需要治疗和/或预防的受试者。 本发明的其它方法包括通过与具有降低的Stat3表达或功能的肿瘤细胞共培养T细胞活化T细胞。 本发明还包括降低Stat3在抗原呈递细胞中的表达或功能的降低，并且向患者共同施用具有降低的Stat3功能的肿瘤细胞和抗原呈递细胞。 本发明还涉及刺激树突状细胞分化的方法。

    Flt3 inhibitors for immune suppression
    15.
    发明申请
    Flt3 inhibitors for immune suppression 审中-公开
    Flt3抑制剂用于免疫抑制

    公开(公告)号：US20090054358A1

    公开(公告)日：2009-02-26

    申请号：US11632924

    申请日：2005-07-14

    申请人： Donald Small ,  Katharine A. Whartenby ,  Drew Pardoll

    发明人： Donald Small ,  Katharine A. Whartenby ,  Drew Pardoll

    IPC分类号： A61K31/7056 ,  C12N5/06 ,  C12N15/87 ,  A01K67/027 ,  C12Q1/02

    CPC分类号： A61K31/553

    摘要： New methods are provided for suppressing the immune system and for treating immune related disorders. Therapies of the invention include administration of an FLT3 inhibitor compound to a subject in need thereof, such as a subject suffering from organ rejection, bone marrow transplant rejection, acquired immune deficiency syndrome, arthritis, aplastic anemia, graft-versus-host disease, Graves' disease, established experimental allergic encephalitomyelitis, multiple sclerosis, lupus, or a neurological disorder. Methods are also provided for screening therapeutic agents for treating immune disorders, including the use of a mouse having an elevated level of FLT3 receptor activity.

    摘要翻译： 提供了用于抑制免疫系统和治疗免疫相关疾病的新方法。 本发明的疗法包括向有需要的受试者施用FLT3抑制剂化合物，例如患有器官排斥，骨髓移植排斥，获得性免疫缺陷综合征，关节炎，再生障碍性贫血，移植物抗宿主病，Graves 疾病，建立的实验性过敏性脑脊髓炎，多发性硬化症，狼疮或神经障碍。 还提供了用于筛选用于治疗免疫疾病的治疗剂的方法，包括使用具有升高的FLT3受体活性水平的小鼠。