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公开(公告)号：US08344162B2
公开(公告)日：2013-01-01
申请号：US13297846
申请日：2011-11-16
IPC分类号： C07D207/40 , C07D207/416
CPC分类号： C07D207/12 , C07C235/14 , C07C2601/14 , C07D207/40
摘要： This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
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12.发明授权公开(公告)号：US07754897B2
公开(公告)日：2010-07-13
申请号：US11455280
申请日：2006-06-15
IPC分类号： C07D207/40 , C07D207/14
CPC分类号： C07D207/12 , C07C235/14 , C07C2601/14 , C07D207/40
摘要： This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
摘要翻译： 本发明涉及式（I）或式（II）化合物或其药学上可接受的盐，酯，酰胺，络合物，螯合物，包合物，溶剂合物，多晶型物，立体异构体，代谢物或前药的立体选择性合成; 其中R 3，R 4和R 5在本文中定义。 已知式（I）和式（II）的化合物可用于治疗心律失常。
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13.发明授权公开(公告)号：US08618311B2
公开(公告)日：2013-12-31
申请号：US13612539
申请日：2012-09-12
IPC分类号： C07D207/40 , C07D207/416
CPC分类号： C07D207/12 , C07C235/14 , C07C2601/14 , C07D207/40
摘要： This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
摘要翻译： 本发明涉及式（I）或式（II）化合物或其药学上可接受的盐，酯，酰胺，络合物，螯合物，包合物，溶剂合物，多晶型物，立体异构体，代谢物或前药的立体选择性合成; 其中R 3，R 4和R 5在本文中定义。 已知式（I）和式（II）的化合物可用于治疗心律失常。
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14.发明申请公开(公告)号：US20130090483A1
公开(公告)日：2013-04-11
申请号：US13612539
申请日：2012-09-12
IPC分类号： C07D207/12
CPC分类号： C07D207/12 , C07C235/14 , C07C2601/14 , C07D207/40
摘要： This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
摘要翻译： 本发明涉及式（I）或式（II）化合物或其药学上可接受的盐，酯，酰胺，络合物，螯合物，包合物，溶剂合物，多晶型物，立体异构体，代谢物或前药的立体选择性合成; 其中R 3，R 4和R 5在本文中定义。 已知式（I）和式（II）的化合物可用于治疗心律失常。
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公开(公告)号：US08058304B2
公开(公告)日：2011-11-15
申请号：US11547422
申请日：2005-04-01
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： A61K31/402 , A61K45/06 , A61K47/55 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D207/14
摘要： Merged compounds of ion channel modulating compounds, including, for example, merged compounds of the ion channel modulating compound of the following formula: (I) are described herein, as well as methods of making and using such merged compounds and pharmaceutical compositions containing such merged compounds.
摘要翻译： 本文描述了合并的离子通道调节化合物的化合物，包括例如下式的（I）的离子通道调节化合物的合并化合物，以及制备和使用这些合并化合物的方法和含有这种合并的药物组合物 化合物。
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16.发明申请公开(公告)号：US20100217014A1
公开(公告)日：2010-08-26
申请号：US12709355
申请日：2010-02-19
IPC分类号： C07D207/40 , C07D207/12 , C07C235/74 , C07D207/416
CPC分类号： C07D207/12 , C07C235/14 , C07C2601/14 , C07D207/40
摘要： This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
摘要翻译： 本发明涉及式（I）或式（II）化合物或其药学上可接受的盐，酯，酰胺，络合物，螯合物，包合物，溶剂合物，多晶型物，立体异构体，代谢物或前药的立体选择性合成; 其中R 3，R 4和R 5在本文中定义。 已知式（I）和式（II）的化合物可用于治疗心律失常。
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公开(公告)号：US07534790B2
公开(公告)日：2009-05-19
申请号：US11944282
申请日：2007-11-21
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/5377 , A61K31/495 , A61K31/426 , A61K31/403 , A61K31/4015 , A61K31/40 , C07D295/033 , C07D413/02 , C07D295/027 , C07D277/04 , C07D209/96 , C07D207/12
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US08008342B2
公开(公告)日：2011-08-30
申请号：US12412010
申请日：2009-03-26
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US07345087B2
公开(公告)日：2008-03-18
申请号：US11394388
申请日：2006-03-30
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/40 , C07D207/12
CPC分类号： C07D207/12 , C07D207/08 , C07D207/10 , C07D207/20 , C07D207/24 , C07D277/04 , C07D295/096 , C07D333/56 , C07D405/12 , C07D487/12 , C07D491/10 , C07D491/113
摘要： Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
摘要翻译： 公开了氨基环己基醚化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了化合物和组合物的用途，包括治疗心律失常。
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公开(公告)号：US07875611B2
公开(公告)日：2011-01-25
申请号：US12424450
申请日：2009-04-15
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/40 , C07D265/30 , C07D207/04
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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